Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Blair Mell"'
Publikováno v:
Physiological Reports, Vol 12, Iss 14, Pp n/a-n/a (2024)
Abstract Dahl salt‐sensitive (SS) rats fed a high‐salt diet, but not low‐salt, exhibit vascular dysfunction. Several substrains of SS rats exist that differ in their blood pressure phenotypes and salt sensitivity. The goal of this study was to
Externí odkaz:
https://doaj.org/article/c9bb3701d0f347ebae0699cc620877dd
Autor:
Xue Mei, Blair Mell, Sachin Aryal, Ishan Manandhar, Ramakumar Tummala, Jasenka Zubcevic, Khanh Lai, Tao Yang, Qiuhong Li, Beng San Yeoh, Bina Joe
Publikováno v:
Pharmacological Research, Vol 196, Iss , Pp 106920- (2023)
Engineered gut microbiota represents a new frontier in medicine, in part serving as a vehicle for the delivery of therapeutic biologics to treat a range of host conditions. The gut microbiota plays a significant role in blood pressure regulation; thu
Externí odkaz:
https://doaj.org/article/0c63133322b94d2ba401c4aae0a09c58
Autor:
Xue Mei, Blair Mell, Ishan Manandhar, Sachin Aryal, Ramakumar Tummala, Jun Kyoung, Tao Yang, Bina Joe
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 24 (2022)
Background The gut and gut microbiota, which were previously neglected in blood pressure regulation, are becoming increasingly recognized as factors contributing to hypertension. Diseases affecting the gut such as inflammatory bowel disease (IBD) pre
Externí odkaz:
https://doaj.org/article/ee8e76c0e34a43969424a5c609c656cc
Autor:
Cameron G. McCarthy, Saroj Chakraborty, Gagandeep Singh, Beng San Yeoh, Zachary J. Schreckenberger, Avinash Singh, Blair Mell, Nicole R. Bearss, Tao Yang, Xi Cheng, Matam Vijay-Kumar, Camilla F. Wenceslau, Bina Joe
Publikováno v:
JCI Insight, Vol 6, Iss 20 (2021)
Autophagy has long been associated with longevity, and it is well established that autophagy reverts and prevents vascular deterioration associated with aging and cardiovascular diseases. Currently, our understanding of how autophagy benefits the vas
Externí odkaz:
https://doaj.org/article/763a5fbdaf5b432c91d5fd854496b7c2
Autor:
Xi Cheng, Blair Mell, Ahmad Alimadadi, Sarah Galla, Cameron G. McCarthy, Saroj Chakraborty, Venkatesha Basrur, Bina Joe
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 5 (2020)
Red blood cell distribution width (RDW) is a measurement of the variation in size and volume of red blood cells (RBCs). Increased RDW, indicating a high heterogeneity of RBCs, is prominently associated with a variety of illnesses, especially cardiova
Externí odkaz:
https://doaj.org/article/59e33835d4de4374927dfa61b8f21735
Autor:
Sarah Galla, Saroj Chakraborty, Xi Cheng, Ji‐Youn Yeo, Blair Mell, Nathaline Chiu, Camilla F. Wenceslau, Matam Vijay‐Kumar, Bina Joe
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 2 (2020)
Background Pediatric hypertension is recognized as an emerging global health concern. Although new guidelines are developed for facilitating clinical management, the reasons for the prevalence of hypertension in children remain unknown. Genetics and
Externí odkaz:
https://doaj.org/article/b802e716728146a78f28ac118306e367
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0221658 (2019)
Fine-mapping of regions linked to the inheritance of hypertension is accomplished by genetic dissection of blood pressure quantitative trait loci (BP QTLs) in rats. The goal of the current study was to further fine-map two genomic regions on rat chro
Externí odkaz:
https://doaj.org/article/7d03c295f68f4b379f63cfd7108aca28
Autor:
Saroj Chakraborty, Sarah Galla, Xi Cheng, Ji-Youn Yeo, Blair Mell, Vishal Singh, BengSan Yeoh, Piu Saha, Anna V. Mathew, Matam Vijay-Kumar, Bina Joe
Publikováno v:
Cell Reports, Vol 25, Iss 3, Pp 677-689.e4 (2018)
Summary: Dietary salt reduction and exercise are lifestyle modifications for salt-sensitive hypertensives. While exercise has prominent metabolic effects, salt has an adverse effect on metabolic syndrome, of which hypertension is a hallmark. We hypot
Externí odkaz:
https://doaj.org/article/becd80229958435d8c3a2344559f9d60
Publikováno v:
PLoS Genetics, Vol 13, Iss 8, p e1006961 (2017)
Multiple GWAS studies have reported strong association of cardiac QT-interval to a region on HSA17. Interestingly, a rat locus homologous to this region is also linked to QT-intervals. The high resolution positional mapping study located the rat QT-i
Externí odkaz:
https://doaj.org/article/9238f9c108f34084854d04d6544e8128
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153519 (2016)
This study is focused on a translationally significant, genome-wide-association-study (GWAS) locus for cardiovascular disease (QT-interval) on human chromosome 17. We have previously validated and high resolution mapped the homologous genomic segment
Externí odkaz:
https://doaj.org/article/62c9eae962a04cbfa23990d46a18eb45