Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Blair K Gage"'
Autor:
Gregory M. Kent, Michael H. Atkins, Bryan Lung, Adele Nikitina, Ian M. Fernandes, Jamie J. Kwan, Tallulah S. Andrews, Sonya A. MacParland, Gordon M. Keller, Blair K. Gage
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114629- (2024)
Summary: In mice, the first liver-resident macrophages, known as Kupffer cells (KCs), are thought to derive from yolk sac (YS) hematopoietic progenitors that are specified prior to the emergence of the hematopoietic stem cell (HSC). To investigate hu
Externí odkaz:
https://doaj.org/article/02df4a49d2314ca5a9d8b39bd4826aa0
Autor:
Blair K Gage, Ali Asadi, Robert K Baker, Travis D Webber, Rennian Wang, Masayuki Itoh, Masaharu Hayashi, Rie Miyata, Takumi Akashi, Timothy J Kieffer
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144100 (2015)
The in vitro differentiation of human embryonic stem cells (hESCs) offers a model system to explore human development. Humans with mutations in the transcription factor Aristaless Related Homeobox (ARX) often suffer from the syndrome X-linked lissenc
Externí odkaz:
https://doaj.org/article/2fe4a7e9a3ec4537a6f8f46a353af561
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82076 (2013)
Human embryonic stem cells (hESCs) have the ability to form cells derived from all three germ layers, and as such have received significant attention as a possible source for insulin-secreting pancreatic beta-cells for diabetes treatment. While consi
Externí odkaz:
https://doaj.org/article/bd46e92955264613aee0c069fc889b7a
Autor:
Jessica A Hill, Marta Szabat, Corinne A Hoesli, Blair K Gage, Yu Hsuan C Yang, David E Williams, Michael J Riedel, Dan S Luciani, Tatyana B Kalynyak, Kevin Tsai, Ziliang Ao, Raymond J Andersen, Garth L Warnock, James M Piret, Timothy J Kieffer, James D Johnson
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12958 (2010)
Diabetes is a devastating disease that is ultimately caused by the malfunction or loss of insulin-producing pancreatic beta-cells. Drugs capable of inducing the development of new beta-cells or improving the function or survival of existing beta-cell
Externí odkaz:
https://doaj.org/article/4597d03eed1c4485a31e9ca5441e029a
Autor:
Arun Ramchandran, Nima Vaezzadeh, Patricia Lavender, Blair K. Gage, Mark D Jeronimo, Arianna Mcallister, Axel Günther, Haotian Chen, Onofrio Laselva, Jia-Xin Jiang, Shinichiro Ogawa, Christine E. Bear, Kelvin Chow, Gordon Keller, Wuyang Gao
Publikováno v:
Advanced healthcare materials. 10(8)
Tubular biological structures consisting of extracellular matrix (ECM) proteins and cells are basic functional units of all organs in animals and humans. ECM protein solutions at low concentrations (5-10 milligrams per milliliter) are abundantly used
Autor:
Sandra Fischer, Blair K. Gage, Juan Echeverri, Jawairia Atif, Justin Manuel, Kyryl Zagorovsky, Cornelia Thoeni, Ben Ouyang, Michael L Cheng, Nicholas Khuu, Iulia Cirlan, Lewis Y. Liu, Danielle P. Ings, Manmeet Sekhon, Gary D. Bader, Annie Y. Chen, Jeff C. Liu, Rahul Gupta, Mohamed A. Abdou Mohamed, Ian D. McGilvray, Sagar Marwah, Tomasz I. Michalak, Warren C. W. Chan, Xue-Zhong Ma, Dagmar Kollmann, Xu-Chun Chen, Sai Chung, Sonya A. MacParland, Damra Camat
Publikováno v:
ACS nano. 14(4)
There is a tremendous focus on the application of nanomaterials for the treatment of cancer. Nonprimate models are conventionally used to assess the biomedical utility of nanomaterials. However, these animals often lack an intact immunological backgr
Autor:
Agata Bartczak, Sonya A. MacParland, Zigong Shao, Shinichiro Ogawa, Justin Manuel, Xue Zhong Ma, Jason E. Fish, Blair K. Gage, Gonzalo Sapisochin, Rahul Gupta, Markus Selzner, Nazia Selzner, Rebecca K. Seliga, Ivan Linares, Michael L Cheng, Juan Echeverri, Gordon Keller, Lewis Y. Liu, Oyedele Adeyi, Paul D. Greig, Damra Camat, Elizabeth Lee, Sai W. Chung, Neil Winegarden, Mina Ogawa, Michael D. Wilson, Brendan T. Innes, Ian D. McGilvray, Jeff C. Liu, Anand Ghanekar, David R. Grant, Nicholas Khuu, Gary D. Bader
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-21 (2018)
The liver is the largest solid organ in the body and is critical for metabolic and immune functions. However, little is known about the cells that make up the human liver and its immune microenvironment. Here we report a map of the cellular landscape
Autor:
Sonya A. MacParland, Ian D. McGilvray, Brendan T. Innes, Jeff C. Liu, Blair K. Gage, Gordon Keller, Gary D. Bader
Publikováno v:
Cell stem cell. 27(2)
Summary Liver sinusoidal endothelial cells (LSECs) form a highly specialized microvasculature that plays a critical role in liver function and disease. To better understand this role, we developed a strategy to generate LSECs from human pluripotent s
Autor:
Connie J. Eaves, Blair K. Gage, James M. Piret, Michael D O'Connor, Nicolas J. Caron, Timothy J. Kieffer
Publikováno v:
Biotechnology and Bioengineering. 110:2706-2716
Human embryonic stem cells (hESCs) can be differentiated into multiple cell types with great therapeutic potential. However, optimizing the often multi-week cultures to obtain sufficient differentiated cell yields has been in part limited by the high
Autor:
Blair K. Gage, Rhonda D. Wideman, Travis D. Webber, Alireza Rezania, Michael J. Riedel, Timothy J. Kieffer, Robert K. Baker, Yukihiro Fujita, Francis Karanu
Publikováno v:
Differentiation. 80:130-139
Islet transplantation represents a potential cure for type 1 diabetes; however, a lack of sufficient donor material limits its clinical use. To address the shortfall of islet availability, surrogate insulin-producing cells are sought. Studies suggest