Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Blair Bleiman"'
Autor:
Jerry Muhammad, Babita Ganguly, Claire Bourdin, Stanley D. Chamberlain, Jeff T. Hutchins, Joseph M. Patti, C. Robin Walters, Andrea Brancale, Alexander A. Kolykhalov, Changalvala V. S. Ramamurty, Christopher McGuigan, Jin Wang, Aleksandr Obikhod, K. Dawn Bryant, Srinivas K. Battina, Elena Gorovits, Blair Bleiman, John Vernachio, Geoffrey W. Henson, Damound Hunley, C.Srivinas Rao
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(7)
7-Deazapurines are known to possess broad antiviral activity, however the 2′-C-methylguanosine analogue displays poor cell permeation and limited phosphorylation, thus is not an efficient inhibitor of hepatitis C virus (HCV) replication. We previou
Autor:
Maria A. Arrica, Jeff T. Hutchins, Jerry Muhammad, C. Robin Walters, Blair Bleiman, John Vernachio, Geoffrey W. Henson, Karolina Madela, Claire Bourdin, K. Dawn Bryant, Damound Hunley, Aleksandr Obikhod, Alexander A. Kolykhalov, Elena Gorovits, Joseph M. Patti, Jin Wang, Emma Barrett, Srinivas K. Battina, Christopher McGuigan, Mohamed Aljarah, Stanley D. Chamberlain, Sarah Jones, Changalvala V. S. Ramamurty, Babita Ganguly
Publikováno v:
Journal of medicinal chemistry. 54(24)
We herein report phosphorodiamidates as a significant new phosphate prodrug motif. Sixty-seven phosphorodiamidates are reported of two 6-O-alkyl 2′-C-methyl guanosines, with significant variation in the diamidate structure. Both symmetrical and asy
Autor:
Geoffrey W. Henson, Jin Wang, K. Dawn Bryant, Christopher McGuigan, Brenda Ames, Joseph M. Patti, Karen Williams, Alexander A. Kolykhalov, Yule Liu, Mohamed Aljarah, Elena Gorovits, Jeff T. Hutchins, Jerry Muhammad, Blair Bleiman, John Vernachio, Damound Hunley, Nicholas Raja, Andrea Hall, Karolina Madela, Arnaud Gilles, Babita Ganguly, C. Robin Walters, Stanley D. Chamberlain
Publikováno v:
Antimicrobial agents and chemotherapy. 55(5)
INX-08189 is an aryl-phosphoramidate of 6- O -methyl-2′- C -methyl guanosine. INX-08189 was highly potent in replicon assays, with a 50% effective concentration of 10 ± 6 nM against hepatitis C genotype 1b at 72 h. The inhibitory effect on viral r
Publikováno v:
The FASEB Journal. 22
Publikováno v:
The Journal of Immunology. 178:S173-S173
Lymphocytes require extrinsic signals to maintain viability and this occurs, in part, through the up-regulation of anti-apoptotic proteins. Several recent studies have implicated cellular energy metabolism as an important component in preventing cell
Autor:
Christopher McGuigan, Karolina Madela, Mohamed Aljarah, Claire Bourdin, Maria Arrica, Emma Barrett, Sarah Jones, Alexander Kolykhalov, Blair Bleiman, K. Dawn Bryant, Babita Ganguly, Elena Gorovits, Geoffrey Henson, Damound Hunley, Jeff Hutchins, Jerry Muhammad, Aleksandr Obikhod, Joseph Patti, C. Robin Walters, Jin Wang
Publikováno v:
Journal of Medicinal Chemistry; Dec2011, Vol. 54 Issue 24, p8632-8645, 14p