Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Blair A. Fraser"'
Autor:
Zachary Shriver, Lucinda F. Buhse, Robert Langer, Gregory Scott Bailey, Sean W. Smith, Mark T. Whary, Ram Sasisekharan, Blair A. Fraser, James G. Fox, Karthik Viswanathan, K. Frank Austen, Thomas Rogers-Cotrone, Kevin D. Pelzer, Sucharita Roy, Moheb Nasr, Zoya Galcheva-Gargova, Subbiah Elankumaran, Ganlin Zhao, Tanmoy Ganguly, Takashi Kei Kishimoto, Gerald J. Dal Pan, Nammalwar Sriranganathan, Jonathan C. Lansing, Janet Woodcock, Ganesh Venkataraman, Ali Al-Hakim
Publikováno v:
New England Journal of Medicine. 358:2457-2467
BACKGROUND There is an urgent need to determine whether oversulfated chondroitin sulfate (OSCS), a compound contaminating heparin supplies worldwide, is the cause of the severe anaphylactoid reactions that have occurred after intravenous heparin admi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ff1d39ea9993869e9169cfe0efae23
https://doi.org/10.1056/nejmoa0803200
https://doi.org/10.1056/nejmoa0803200
Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events
Autor:
Janet Woodcock, Zhenqing Zhang, Daniela Beccati, Blair A. Fraser, Giangiacomo Torri, Jonathan C. Lansing, Antonella Bisio, Luke Robinson, Robert J. Linhardt, Sara Guglieri, Moheb Nasr, Benito Casu, Annamaria Naggi, Nur Sibel Gunay, Ram Sasisekharan, Ali Al-Hakim, Ganesh Venkataraman, Ishan Capila, Marco Guerrini, Karthik Viswanathan, Robert Langer, Zachary Shriver, Lucinda F. Buhse
Publikováno v:
Nature Biotechnology. 26:669-675
Heparin has been used clinically as an anticoagulant for over 60 years. Typically isolated from porcine intestine, heparin is a mixture of dimeric glycosidic sequences generating complex polysaccharide glycosaminoglycan chains. Recently, certain lots
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7480c5f1b3f52c148c75c2c11534ed4
https://doi.org/10.1038/nbt1407
https://doi.org/10.1038/nbt1407
Autor:
Emily Shacter, Janet Woodcock, Keith Webber, Steven Kozlowski, Amy S. Rosenberg, Dena R. Hixon, Barry Cherney, Rachel E. Behrman, Helen Winkle, Lewis Schrager, Robert Temple, Christopher Joneckis, Blair A. Fraser, Terrie Crescenzi, Joseph C M Griffin
Publikováno v:
Nature Reviews Drug Discovery. 6:437-442
The scientific and regulatory issues that are associated with the possible introduction of 'follow-on' versions of protein drug products are the topic of considerable debate at present. Because of the differences between protein drug products and sma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25a0e29f1cd3f2920771e4e18df8a865
https://doi.org/10.1038/nrd2307
https://doi.org/10.1038/nrd2307
Autor:
Blair A. Fraser, R.M. Wagner
Publikováno v:
Biological Mass Spectrometry. 14:235-239
beta-Lipotrophin (62-77) or Ac-gastrin releasing peptide was incubated with immobilized carboxypeptidase Y or aminopeptidase M. Subsequent aliquots of each incubation mixture were analysed by fast atom bombardment mass spectrometry using a dithiothre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0a88a6344ac2d1ccea56b1f3f634f3c
https://doi.org/10.1002/bms.1200140507
https://doi.org/10.1002/bms.1200140507
Publikováno v:
Biological Mass Spectrometry. 10:387-393
Under negative ionization conditions, nominal mass calibration of the fast atom bombardment high field mass spectrometer and data system was accomplished using cesium iodide/glycerol as a reference. Mass calibration at −8 kV accelerating potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59826812a6eea8c7f4c0c2835333eaed
https://doi.org/10.1002/bms.1200100609
https://doi.org/10.1002/bms.1200100609
Autor:
Blair A. Fraser, Alexander M. Buko
Publikováno v:
Biological Mass Spectrometry. 12:577-585
Ten peptides containing one, two or three disulfides were examined to determine their behavior under fast atom bombardment (FAB) mass spectrometric conditions. The mass spectra for the disulfide and the reduced disulfide forms of each peptide were co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b077a66b89ae22791e010f5a71b62df
https://doi.org/10.1002/bms.1200121002
https://doi.org/10.1002/bms.1200121002
Publikováno v:
Biological Mass Spectrometry. 10:408-419
Sixteen peptides ranging in molecular weights from 858 to 5729 were examined under positive ionization fast atom bombardment conditions employing a high field magnet mass spectrometer and data system. The contributions of the polyisotopic elements to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbdbc0e840b544aafdc3e0c6d6edc5a4
https://doi.org/10.1002/bms.1200100705
https://doi.org/10.1002/bms.1200100705
Publikováno v:
The Journal of Immunology. 118:6-11
A disaccharide hapten was isolated in approximately 20% yield from an acid hydrolysate of the streptococcal Group C carbohydrate. This disaccharide was assigned the structure 3-0-α-N-acetylgalactosaminosyl-N-acetylgalactosamine on the basis of chemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87bbd32fbf53993074210c192d68597b
https://doi.org/10.4049/jimmunol.118.1.6
https://doi.org/10.4049/jimmunol.118.1.6
Publikováno v:
The Journal of Immunology. 121:1132-1138
Latent group a allotypes were detected with a sensitive radioimmune inhibition assay. Sera, IgG preparations, and antibody fractions containing these allotypes inhibited the binding of insolubilized allotypic antisera to various radiolabeled antigens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::966f7ceac59433582e4881884eea784b
https://doi.org/10.4049/jimmunol.121.3.1132
https://doi.org/10.4049/jimmunol.121.3.1132
Autor:
Blair A. Fraser, Lawrence R. Phillips
Publikováno v:
Biological Mass Spectrometry. 8:327-331
Detection and identification of low levels (⩽200 ppb) of free β-propiolactone in complex biological mixtures were achieved through in situ chemical derivatization and subsequent gas chromatographic mass spectrometric determination of the products.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15b61c3bdbc99131453e96ba292414af
https://doi.org/10.1002/bms.1200080802
https://doi.org/10.1002/bms.1200080802