Zobrazeno 1 - 10 of 35 pro vyhledávání: '"Blaine M. Sutton"'
1
An alternate synthesis, x-ray crystal structure and p388 activity of 1,2-bis(dibenzophospholyl-1)ethane
Autor: Drake S. Eggleston, Randall K. Johnson, Leo F. Faucette, Paul W. Baures, Gerald R. Girard, Blaine M. Sutton, David T. Hill
Publikováno v: Journal of Heterocyclic Chemistry. 27:1123-1126
Synthesis of 1,2-bis(dibenzophospholyl-l)ethane (2) in 45% yield was accomplished in a single step via the coupling of 2,2′-dilithiobiphenyl with 1,2-bis(dichlorophosphino)ethane. The dilithio reagent was generated in situ by the metalation of 2,2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::470038f0758b588e47aa7eaf691adb07
https://doi.org/10.1002/jhet.5570270459
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3
Cytotoxicity and antitumor activity of some tetrahedral bis(diphosphino)gold(I) chelates
Autor: Blaine M. Sutton, David T. Hill, Gerald R. Girard, Penelope S. Jarrett, Leo F. Faucette, Randall K. Johnson, Christopher K. Mirabelli, Susan J. Berners-Price, Peter J. Sadler
Publikováno v: Journal of medicinal chemistry. 33(5)
We report the cytotoxicity toward B16 cells and antitumor activity in three transplantable tumor models of a series of ionic, tetrahedral, bischelated gold diphosphine complexes of the type [Au1(R2PYPR2')2]X, where Y = (CH2)2, (CH2)3, or cis-CH = CH.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29391fa49380dfa4fff1f95c530cf231
https://pubmed.ncbi.nlm.nih.gov/2329559
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4
Synthesis of 195Au, 32P and 35S-labelled auranofin, A novel orally effective gold antiarthritic drug
Autor: Joseph Meier, Smith Kline, Blaine M. Sutton, David T. Hill, Sidney H. Levinson
Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 20:363-375
Auranofin (1), a phosphine gold(I) thiolate antiarthritic agent effective on oral administration, was labelled separately with 195Au, 32P and 35S. 195Au-labelled auranofin 19 was made from H195AuCl4.3H20via the intermediate chloro(triethylphosphine)g
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3084419cea31ee066ccc1ba0f9be81d7
https://doi.org/10.1002/jlcr.2580200306
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5
Pyranenamines: a new series of antiallergic compounds
Autor: Kenneth M. Snader, Chester Rhodes Willis, D H Shah, J. W. Venslavsky, R D Cramer rd, Y. M. Gelernt, Blaine M. Sutton, L. W. Chakrin, C. K. Miao
Publikováno v: Journal of Medicinal Chemistry. 22:706-714
Condensation of 3,5-diacylpyrantriones with various aromatic amines gave a new class of potent, orally active, antiallergic compounds, the 3-[(arylamino)ethylidene]-5-acylpyrantriones, hereafter referred to as pyranenamines, as evaluated not only in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aafe571f8654d87ed65da47475bda2b
https://doi.org/10.1021/jm00192a018
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7
Proton, carbon-13, and phosphorus-31 nuclear magnetic resonance studies of (2,3,4,6-tetra-O-acetyl-1-thio-β-D-glucopyranosato-S)(triethylphosphine)gold (auranofin), a novel antiarthritic agent
Autor: Peter J. Sadler, Blaine M. Sutton, David T. Hill, M. Tahir Razi
Publikováno v: J. Chem. Soc., Dalton Trans.. :1331-1334
The 1H and 13C high-field n.m.r. spectra of auranofin in a variety of aqueous and non-aqueous solvents have been analysed and all peaks unambiguously assigned except those for the acetyl groups. Specific solvation and co-ordination shifts are discuss
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea1670df0345b966cc8b4787c7ef7be8
https://doi.org/10.1039/dt9830001331
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8
Antiinflammatory activity of 5,6-diaryl-2,3-dihydroimidazo[2,1-b]thiazoles. Isomeric 4-pyridyl and 4-substituted-phenyl derivatives
Autor: D. E. Griswold, D. T. Walz, Blaine M. Sutton, Ivan Lantos, Paul Elliot Bender, K. A. Razgaitis, M. J. Dimartino
Publikováno v: Journal of Medicinal Chemistry. 27:72-75
Isomeric 5(6)-(4-pyridyl)- and 6(5)-(4-substituted-phenyl)-2,3-dihydroimidazo[2,1-b]thiazoles were prepared by a mixed benzoin-imidazothione route, and their structures were assigned by spectral comparison to compounds of established substitution pat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cab33a902eeffc59159f09643594ed5
https://doi.org/10.1021/jm00367a014
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