Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Blaine J Zern"'
Autor:
M Carme Coll Ferrer, Vladimir V Shuvaev, Blaine J Zern, Russell J Composto, Vladimir R Muzykantov, David M Eckmann
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102329 (2014)
Lysozyme dextran nanogels (NG) have great potential in vitro as a drug delivery platform, combining simple chemistry with rapid uptake and cargo release in target cells with "stealth" properties and low toxicity. In this work, we study for the first
Externí odkaz:
https://doaj.org/article/5e39f1d9f7e24a8bb220d96a423d3607
Autor:
Colin F Greineder, Ann-Marie Chacko, Sergei Zaytsev, Blaine J Zern, Ronald Carnemolla, Elizabeth D Hood, Jingyan Han, Bi-Sen Ding, Charles T Esmon, Vladimir R Muzykantov
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80110 (2013)
The use of targeted therapeutics to replenish pathologically deficient proteins on the luminal endothelial membrane has the potential to revolutionize emergency and cardiovascular medicine. Untargeted recombinant proteins, like activated protein C (A
Externí odkaz:
https://doaj.org/article/5b46ccfab9ca479b9559e7eb89df9a94
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11017 (2010)
The importance of growth factors has been recognized for over five decades; however their utilization in medicine has yet to be fully realized. This is because free growth factors have short half-lives in plasma, making direct injection inefficient.
Externí odkaz:
https://doaj.org/article/a4dca7da41634acea618406b9af34723
Autor:
Jessica Campo, Vladimir R. Muzykantov, Vladimir V. Shuvaev, Jacob W. Myerson, Abhay Ranganathan, Blaine J. Zern, David M. Eckmann
Publikováno v:
Journal of biomedical nanotechnology. 13(6)
Targeted drug delivery is a fast growing industry in healthcare and technologies are being developed for applications utilizing nanocarriers as vehicles for drug transport. As the size scale of these particles becomes further reduced, advanced fluore
Autor:
John L. Mikitsh, Vladimir R. Muzykantov, Ian Johnston, Jingyan Han, Peter F. Davies, Colin F. Greineder, David M. Eckmann, Madhura Nayak, Divya Menon, Mortimer Poncz, Ann-Marie Chacko, Blaine J. Zern
Publikováno v:
ACS Nano. 9:6785-6793
Nanocarriers (NCs) coated with antibodies (Abs) to extracellular epitopes of the transmembrane glycoprotein PECAM (platelet endothelial cell adhesion molecule-1/CD31) enable targeted drug delivery to vascular endothelial cells. Recent studies reveale
Autor:
Ann-Marie Chacko, Blaine J. Zern, Jin Liu, Vladimir R. Muzykantov, Eric Blankemeyer, Colin F. Greineder, Ravi Radhakrishnan
Publikováno v:
ACS Nano. 7:2461-2469
Targeting nanoparticles (NPs) loaded with drugs and probes to precise locations in the body may improve the treatment and detection of many diseases. Generally, to achieve targeting, affinity ligands are introduced on the surface of NPs that can bind
Publikováno v:
Current Opinion in Colloid & Interface Science. 16:215-227
Vascular inflammation is a common, complex mechanism involved in pathogenesis of a plethora of disease conditions including ischemia-reperfusion, atherosclerosis, restenosis and stroke. Specific targeting of imaging probes and drugs to endothelial ce
Autor:
Vladimir R. Muzykantov, Jin Liu, David M. Eckmann, Portonovo S. Ayyaswamy, Ravi Radhakrishnan, Gregory E. R. Weller, Blaine J. Zern
Publikováno v:
Proceedings of the National Academy of Sciences. 107:16530-16535
A computational methodology based on Metropolis Monte Carlo (MC) and the weighted histogram analysis method (WHAM) has been developed to calculate the absolute binding free energy between functionalized nanocarriers (NC) and endothelial cell (EC) sur
Publikováno v:
Materials Science Forum. :547-550
Most biomaterials widely used in nerve regeneration are either inert or modified with ECM proteins or their epitopes. Neurotransmitters play a key role in neuronal development and function. Thus we decided to investigate the feasibility of using neur
Autor:
Vladimir V. Shuvaev, Blaine J. Zern, Vladimir R. Muzykantov, Aaron C. Anselmo, Samir Mitragotri, Melissa D. Howard
Publikováno v:
ACS Nano
Targeted nanomedicine holds promise to find clinical use in many medical areas. Endothelial cells that line the luminal surface of blood vessels represent a key target for treatment of inflammation, ischemia, thrombosis, stroke, and other neurologica