Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Blaine A. Pfeifer"'
Publikováno v:
npj Systems Biology and Applications, Vol 9, Iss 1, Pp 1-10 (2023)
Abstract Recent global events have drawn into focus the diversity of options for combatting disease across a spectrum of prophylactic and therapeutic approaches. The recent success of the mRNA-based COVID-19 vaccines has paved the way for RNA-based t
Externí odkaz:
https://doaj.org/article/972a3f707f6140c4ad753f97f0c16fd7
Publikováno v:
Synthetic and Systems Biotechnology, Vol 6, Iss 1, Pp 1-11 (2021)
Natural products have had a major impact upon quality of life, with antibiotics as a classic example of having a transformative impact upon human health. In this contribution, we will highlight both historic and emerging methods of natural product bi
Externí odkaz:
https://doaj.org/article/46f9a99cf18a4678a7b8445188cbaa9e
Autor:
Manmeet Bhalla, Roozbeh Nayerhoda, Essi Y. I. Tchalla, Alexsandra Abamonte, Dongwon Park, Shaunna R. Simmons, Blaine A. Pfeifer, Elsa N. Bou Ghanem
Publikováno v:
Frontiers in Aging, Vol 2 (2021)
Despite the availability of licensed vaccines, pneumococcal disease caused by the bacteria Streptococcus pneumoniae (pneumococcus), remains a serious infectious disease threat globally. Disease manifestations include pneumonia, bacteremia, and mening
Externí odkaz:
https://doaj.org/article/131f469762134caaa478fa956ac4842f
Autor:
Caitlin D. Bohannon, Zachary Ende, Weiping Cao, Wadzanai P. Mboko, Priya Ranjan, Amrita Kumar, Margarita Mishina, Samuel Amoah, Shivaprakash Gangappa, Suresh K. Mittal, Jonathan F. Lovell, Adolfo García‐Sastre, Blaine A. Pfeifer, Bruce A. Davidson, Paul Knight, Suryaprakash Sambhara
Publikováno v:
Advanced Science, Vol 8, Iss 16, Pp n/a-n/a (2021)
Abstract Influenza infections cause several million cases of severe respiratory illness, hospitalizations, and hundreds of thousands of deaths globally. Secondary infections are a leading cause of influenza's high morbidity and mortality, and signifi
Externí odkaz:
https://doaj.org/article/404ee5401a084d95a30c1ea15b5a9472
Publikováno v:
iScience, Vol 23, Iss 4, Pp - (2020)
Summary: Siderophores are small molecule metal chelators secreted in sparse quantities by their native microbial hosts but can be engineered for enhanced production from heterologous hosts like Escherichia coli. These molecules have been proved to be
Externí odkaz:
https://doaj.org/article/72cf0848a8d943b2b740198730954ea0
Publikováno v:
Vaccines, Vol 9, Iss 6, p 589 (2021)
This mini-review will cover recent trends in intranasal (IN) vaccine delivery as it relates to applications for respiratory tract diseases. The logic and rationale for IN vaccine delivery will be compared to methods and applications accompanying this
Externí odkaz:
https://doaj.org/article/685cc7a50674412f8e029fcbe211af58
Autor:
Marie Beitelshees, Andrew Hill, Yi Li, Mingfu Chen, Mahmoud Kamal Ahmadi, Randall J. Smith, Jr, Stelios T. Andreadis, Pooya Rostami, Charles H. Jones, Blaine A. Pfeifer
Publikováno v:
Vaccine: X, Vol 1, Iss , Pp - (2019)
A hybrid biological-biomaterial antigen delivery vector comprised of a polymeric shell encapsulating an Escherichia coli core was previously developed for in situ antigen production and subsequent delivery. Due to the engineering capacity of the bact
Externí odkaz:
https://doaj.org/article/1a8e159e5dbe47ebb2a0dc34caea7338
Publikováno v:
Materials, Vol 13, Iss 15, p 3320 (2020)
The Liposomal Encapsulation of Polysaccharides (LEPS) dual antigen vaccine carrier system was assessed across two distinct polysaccharides for encapsulation efficiency, subsequent liposomal surface adornment with protein, adjuvant addition, and size
Externí odkaz:
https://doaj.org/article/8c2d20b5c79145a2892b040f716e696a
Autor:
Amin Jafari, Nika Rajabian, Guojian Zhang, Mohamed Alaa Mohamed, Pedro Lei, Stelios T. Andreadis, Blaine A. Pfeifer, Chong Cheng
Publikováno v:
Materials, Vol 13, Iss 4, p 898 (2020)
As a promising strategy for the treatment of various diseases, gene therapy has attracted increasing attention over the past decade. Among various gene delivery approaches, non-viral vectors made of synthetic biomaterials have shown significant poten
Externí odkaz:
https://doaj.org/article/c2d425a76c0d48f69b89ac346e925453
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Salicylate 2-O-β-D-glucoside (SAG) is a plant-derived natural product with potential utility as both an anti-inflammatory and as a plant protectant compound. Heterologous biosynthesis of SAG has been established in Escherichia coli through metabolic
Externí odkaz:
https://doaj.org/article/9ab9c7afbd9c456aa1531a117d2dcbe3