Výsledky vyhledávání - "Bladeren, P.J. van"

A physiologically based biokinetic (PBBK) model for estragole bioactivation and detoxification in rat

Autor: Punt, A., Freidig, A.P., Delatour, T., Scholz, G., Boersma, M.G., Schilter, B., Bladeren, P.J. van, Rietjens, I.M.C.M.

Publikováno v: Toxicology and Applied Pharmacology, 2, 231, 248-259

The present study defines a physiologically based biokinetic (PBBK) model for the alkenylbenzene estragole in rat based on in vitro metabolic parameters determined using relevant tissue fractions, in silico derived partition coefficients, and physiol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::94246a661211cf089d143d84089f7aad
http://resolver.tudelft.nl/uuid:127924b6-57bb-4d52-9bc3-a574a893039e

Zobrazit plný text záznamu

Association between consumption of cruciferous vegetables and condiments and excretion in urine of isothiocyanate mercapturic acids

Autor: Vermeulen, M., Berg, R. van den, Freidig, A.P., Bladeren, P.J. van, Vaes, W.H.J.

Publikováno v: Journal of Agricultural and Food Chemistry, 15, 54, 5350-5358

A high intake of cruciferous vegetables is associated with a reduced risk of cancer and cardiovascular diseases. This protective effect has been linked to isothiocyanates, enzymatic hydrolysis products of glucosinolates. In this study, the metabolic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::697a3a7f065231bebd26e5e66eac5d01
http://resolver.tudelft.nl/uuid:ea66f835-1e01-4ce3-bd8f-84823d644a39

Zobrazit plný text záznamu

Flavonoid-mediated inhibition of intestinal ABC transporters may affect the oral bioavailability of drugs, food-borne toxic compounds and bioactive ingredients

Autor: Brand, W., Schutte, M.E., Williamson, G., Zanden, J.J. van, Cnubben, N.H.P., Groten, J.P., Bladeren, P.J. van, Rietjens, I.M.C.M.

Publikováno v: Biomedicine and Pharmacotherapy, 9, 60, 508-519

The transcellular transport of ingested food ingredients across the intestinal epithelial barrier is an important factor determining bioavailability upon oral intake. This transcellular transport of many chemicals, food ingredients, drugs or toxic co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2f57c0243ae209cd3ddd52d5b4a90657
http://resolver.tudelft.nl/uuid:ac41cebc-e8b7-425c-a377-e02721e607ed

Zobrazit plný text záznamu

The use of in vitro metabolic parameters and physiologically based pharmacokinetic (PBPK) modeling to explore the risk assessment of trichloroethylene

Autor: Hissink, E.M., Bogaards, J.J.P., Freidig, A.P., Commandeur, J.N.M., Vermeulen, N.P.E., Bladeren, P.J. van

Publikováno v: Environmental Toxicology and Pharmacology, 3-4, 11, 259-271

A physiologically based pharmacokinetic (PBPK) model has been developed for trichloroethylene (1,1,2-trichloroethene, TRI) for rat and humans, based on in vitro metabolic parameters. These were obtained using individual cytochrome P450 and glutathion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ddc32eaf7e12772e15f69ebde17560ac
http://resolver.tudelft.nl/uuid:353b6b4f-f909-403b-9839-c83de9f3f8df

Zobrazit plný text záznamu

Prediction of isoprene diepoxide levels in vivo in mouse, rat and man using enzyme kinetic data in vitro and physiologically-based pharmacokinetic modelling

Autor: Bogaards, J.J.P., Freidig, A.P., Bladeren, P.J. van

Publikováno v: Chemico-Biological Interactions, 138, 247-265

The present study was designed to explain the differences in isoprene toxicity between mouse and rat based on the liver concentrations of the assumed toxic metabolite isoprene diepoxide. In addition, extrapolation to the human situation was attempted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::fc34fac313695d84872b9902666a64b7
http://resolver.tudelft.nl/uuid:1f0a0d20-e34c-4a21-bce4-48374c4e3f3f

Zobrazit plný text záznamu

A physiologically-based pharmacokinetic (PB-PK) model for ethylene dibromide: relevance of extrahepatic metabolism

Autor: Hissink, A.M., Wormhoudt, L.W., Sherratt, P.J., Hayes, J.D., Commandeur, J.N.M., Vermeulen, N.P.E., Bladeren, P.J. van

Publikováno v: Food and Chemical Toxicology, 38, 707-716

A physiologically-based pharmacokinetic (PB-PK) model was developed for ethylene dibromide (1,2-dibromoethane, EDB) for rats and humans, partly based on previously published in vitro data (Ploemen et al., 1997). In the present study, this PB-PK model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e030b2c531a17b7fda8d53e38845335a
http://resolver.tudelft.nl/uuid:41010b49-00ed-4135-ba00-5c81b22f33fe

Zobrazit plný text záznamu

Glutathione conjugation as a bioactivation reaction

Autor: Bladeren, P.J. van

Publikováno v: Chemico-Biological Interactions, 1-2, 129, 61-76

In general, glutathione conjugation is regarded as a detoxication reaction. However, depending on the properties of the substrate, bioactivation is also possible. Four types of activation reaction have been recognized: direct-acting compounds, conjug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::26a2dbc8128eaeef0db1e039a60dd229
http://resolver.tudelft.nl/uuid:6a6d9ed0-cb90-45ea-add1-eba265260625

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání