Age-related decline of the unfolded protein response in the heart promotes protein misfolding and cardiac pathology

Autor: Christoph Hofmann, Julia Groß, Jakobi T, Hugo A. Katus, Blackwood Ea, Doroudgar S, Clara Sandmann, Randal J. Kaufman, Glembotski Cc, Mirko Völkers, Nicole Herzog

Cardiac myocyte death during heart failure is particularly detrimental, given that cardiac muscle exhibits limited regenerative potential. Protein aggregation was previously observed in end-stage heart failure, suggesting protein-misfolding in cardia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::985c81f9c7ca020861a3a412562c9f86
https://doi.org/10.1101/2021.06.16.448596

ATF6 protects against protein misfolding during cardiac hypertrophy.

Autor: Hofmann C; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany; SDSU Heart Institute and Department of Biology, San Diego State University, San Diego, CA, USA., Aghajani M; Department of Internal Medicine and the Translational Cardiovascular Research Center, University of Arizona College of Medicine - Phoenix, Phoenix, USA., Alcock CD; Department of Internal Medicine and the Translational Cardiovascular Research Center, University of Arizona College of Medicine - Phoenix, Phoenix, USA., Blackwood EA; Department of Internal Medicine and the Translational Cardiovascular Research Center, University of Arizona College of Medicine - Phoenix, Phoenix, USA., Sandmann C; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany., Herzog N; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany., Groß J; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany., Plate L; Department of Chemistry, Vanderbilt University, Nashville, TN, USA; Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA., Wiseman RL; Department of Molecular Medicine, Scripps Research, La Jolla, CA, USA., Kaufman RJ; Degenerative Diseases Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA., Katus HA; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany., Jakobi T; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany; Department of Internal Medicine and the Translational Cardiovascular Research Center, University of Arizona College of Medicine - Phoenix, Phoenix, USA., Völkers M; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany., Glembotski CC; Department of Internal Medicine and the Translational Cardiovascular Research Center, University of Arizona College of Medicine - Phoenix, Phoenix, USA., Doroudgar S; Department of Internal Medicine III (Cardiology, Angiology, and Pneumology), Heidelberg University Hospital, Heidelberg, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany; Department of Internal Medicine and the Translational Cardiovascular Research Center, University of Arizona College of Medicine - Phoenix, Phoenix, USA. Electronic address: sdoroudgar@arizona.edu.

Publikováno v: Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2024 Apr; Vol. 189, pp. 12-24. Date of Electronic Publication: 2024 Feb 23.

Optimization of Large-Scale Adeno-Associated Virus (AAV) Production.

Autor: Bilal AS; University of Arizona College of Medicine Phoenix, Arizona., Parker SN; University of Arizona College of Medicine Phoenix, Arizona., Murray VB; University of Arizona College of Medicine Phoenix, Arizona., MacDonnell LF; University of Arizona College of Medicine Phoenix, Arizona., Thuerauf DJ; San Diego State University, San Diego, California., Glembotski CC; University of Arizona College of Medicine Phoenix, Arizona., Blackwood EA; University of Arizona College of Medicine Phoenix, Arizona.

Publikováno v: Current protocols [Curr Protoc] 2023 May; Vol. 3 (5), pp. e757.

Noncanonical Form of ERAD Regulates Cardiac Hypertrophy.

Autor: Blackwood EA; Translational Cardiovascular Research Center and Department of Internal Medicine, University of Arizona College of Medicine-Phoenix (E.A.B., L.F.M., A.S.B., V.B.M., C.C.G.)., MacDonnell LF; Translational Cardiovascular Research Center and Department of Internal Medicine, University of Arizona College of Medicine-Phoenix (E.A.B., L.F.M., A.S.B., V.B.M., C.C.G.)., Thuerauf DJ; San Diego State University Heart Institute and Department of Biology, San Diego State University, CA (D.J.T.)., Bilal AS; Translational Cardiovascular Research Center and Department of Internal Medicine, University of Arizona College of Medicine-Phoenix (E.A.B., L.F.M., A.S.B., V.B.M., C.C.G.)., Murray VB; Translational Cardiovascular Research Center and Department of Internal Medicine, University of Arizona College of Medicine-Phoenix (E.A.B., L.F.M., A.S.B., V.B.M., C.C.G.)., Bedi KC Jr; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia (K.C.B., K.B.M.)., Margulies KB; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia (K.C.B., K.B.M.)., Glembotski CC; Translational Cardiovascular Research Center and Department of Internal Medicine, University of Arizona College of Medicine-Phoenix (E.A.B., L.F.M., A.S.B., V.B.M., C.C.G.).

Publikováno v: Circulation [Circulation] 2023 Jan 03; Vol. 147 (1), pp. 66-82. Date of Electronic Publication: 2022 Nov 01.

Design and Production of Heart Chamber-Specific AAV9 Vectors.

Autor: Bilal AS; Translational Cardiovascular Research Center and Department of Internal Medicine, University of Arizona College of Medicine - Phoenix, Phoenix, AZ, USA., Thuerauf DJ; Department of Cellular and Molecular Biology, San Diego State University, San Diego, CA, USA., Blackwood EA; Translational Cardiovascular Research Center and Department of Internal Medicine, University of Arizona College of Medicine - Phoenix, Phoenix, AZ, USA., Glembotski CC; Translational Cardiovascular Research Center and Department of Internal Medicine, University of Arizona College of Medicine - Phoenix, Phoenix, AZ, USA. cglembotski@arizona.edu.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2573, pp. 89-113.