Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.

Autor: Wray NR; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. naomi.wray@uq.edu.au.; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. naomi.wray@uq.edu.au., Ripke S; Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Department of Psychiatry and Psychotherapy, Universitätsmedizin Berlin Campus Charité Mitte, Berlin, Germany., Mattheisen M; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden., Trzaskowski M; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Byrne EM; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Abdellaoui A; Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Adams MJ; Division of Psychiatry, University of Edinburgh, Edinburgh, UK., Agerbo E; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Centre for Integrated Register-Based Research, Aarhus University, Aarhus, Denmark.; National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark., Air TM; Discipline of Psychiatry, University of Adelaide, Adelaide, South Australia, Australia., Andlauer TMF; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Bacanu SA; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA., Bækvad-Hansen M; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark., Beekman AFT; Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, The Netherlands., Bigdeli TB; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.; Virginia Institute for Psychiatric and Behavior Genetics, Richmond, VA, USA., Binder EB; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA., Blackwood DRH; Division of Psychiatry, University of Edinburgh, Edinburgh, UK., Bryois J; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Buttenschøn HN; iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Department of Clinical Medicine, Translational Neuropsychiatry Unit, Aarhus University, Aarhus, Denmark., Bybjerg-Grauholm J; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark., Cai N; Statistical Genomics and Systems Genetics, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK.; Human Genetics, Wellcome Trust Sanger Institute, Cambridge, UK., Castelao E; Department of Psychiatry, University Hospital of Lausanne, Prilly, Switzerland., Christensen JH; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark., Clarke TK; Division of Psychiatry, University of Edinburgh, Edinburgh, UK., Coleman JIR; MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, UK., Colodro-Conde L; Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Couvy-Duchesne B; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.; Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia., Craddock N; Psychological Medicine, Cardiff University, Cardiff, UK., Crawford GE; Center for Genomic and Computational Biology, Duke University, Durham, NC, USA.; Department of Pediatrics, Division of Medical Genetics, Duke University, Durham, NC, USA., Crowley CA; Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Dashti HS; Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Davies G; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK., Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK., Degenhardt F; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Life & Brain Center, Department of Genomics, University of Bonn, Bonn, Germany., Derks EM; Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Direk N; Psychiatry, Dokuz Eylul University School of Medicine, Izmir, Turkey.; Epidemiology, Erasmus MC, Rotterdam, The Netherlands., Dolan CV; Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Dunn EC; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.; Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Massachusetts General Hospital, Boston, MA, USA., Eley TC; MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, UK., Eriksson N; Research, 23andMe, Inc., Mountain View, CA, USA., Escott-Price V; Neuroscience and Mental Health, Cardiff University, Cardiff, UK., Kiadeh FHF; Bioinformatics, University of British Columbia, Vancouver, British Columbia, Canada., Finucane HK; Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.; Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA, USA., Forstner AJ; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Life & Brain Center, Department of Genomics, University of Bonn, Bonn, Germany.; Department of Psychiatry (UPK), University of Basel, Basel, Switzerland.; Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland., Frank J; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Gaspar HA; MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, UK., Gill M; Department of Psychiatry, Trinity College Dublin, Dublin, Ireland., Giusti-Rodríguez P; Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Goes FS; Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA., Gordon SD; Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Grove J; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark., Hall LS; Division of Psychiatry, University of Edinburgh, Edinburgh, UK.; Institute of Genetic Medicine, Newcastle University, Newcastle-upon-Tyne, UK., Hannon E; University of Exeter Medical School, Exeter, UK., Hansen CS; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark., Hansen TF; Danish Headache Centre, Department of Neurology, Rigshospitalet, Glostrup, Denmark.; Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Capital Region of Denmark, Copenhagen, Denmark.; iPSYCH, Lundbeck Foundation Initiative for Psychiatric Research, Copenhagen, Denmark., Herms S; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Life & Brain Center, Department of Genomics, University of Bonn, Bonn, Germany.; Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland., Hickie IB; Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia., Hoffmann P; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Life & Brain Center, Department of Genomics, University of Bonn, Bonn, Germany.; Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland., Homuth G; Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University Medicine and Ernst Moritz Arndt University Greifswald, Greifswald, Germany., Horn C; Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche, Ltd, Basel, Switzerland., Hottenga JJ; Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Hougaard DM; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark., Hu M; Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA., Hyde CL; Statistics, Pfizer Global Research and Development, Groton, CT, USA., Ising M; Max Planck Institute of Psychiatry, Munich, Germany., Jansen R; Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, The Netherlands., Jin F; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA., Jorgenson E; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA., Knowles JA; Psychiatry and Behavioral Sciences, University of Southern California, Los Angeles, CA, USA., Kohane IS; Informatics Program, Boston Children's Hospital, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA., Kraft J; Department of Psychiatry and Psychotherapy, Universitätsmedizin Berlin Campus Charité Mitte, Berlin, Germany., Kretzschmar WW; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Krogh J; Department of Endocrinology at Herlev University Hospital, University of Copenhagen, Copenhagen, Denmark., Kutalik Z; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Institute of Social and Preventive Medicine (IUMSP), University Hospital of Lausanne, Lausanne, Switzerland., Lane JM; Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA., Li Y; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Li Y; Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Lind PA; Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Liu X; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA., Lu L; Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA., MacIntyre DJ; Mental Health, NHS 24, Glasgow, UK.; Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., MacKinnon DF; Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA., Maier RM; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia., Maier W; Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany., Marchini J; Statistics, University of Oxford, Oxford, UK., Mbarek H; Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., McGrath P; Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA., McGuffin P; MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, UK., Medland SE; Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Mehta D; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.; School of Psychology and Counseling, Queensland University of Technology, Brisbane, Queensland, Australia., Middeldorp CM; Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Child and Youth Mental Health Service, Children's Health Queensland Hospital and Health Service, South Brisbane, Queensland, Australia.; Child Health Research Centre, University of Queensland, Brisbane, Queensland, Australia., Mihailov E; Estonian Genome Center, University of Tartu, Tartu, Estonia., Milaneschi Y; Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, The Netherlands., Milani L; Estonian Genome Center, University of Tartu, Tartu, Estonia., Mill J; University of Exeter Medical School, Exeter, UK., Mondimore FM; Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA., Montgomery GW; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Mostafavi S; Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.; Statistics, University of British Columbia, Vancouver, British Columbia, Canada., Mullins N; MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, UK., Nauck M; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, University Medicine, University Medicine Greifswald, Greifswald, Germany.; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany., Ng B; Statistics, University of British Columbia, Vancouver, British Columbia, Canada., Nivard MG; Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Nyholt DR; Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia., O'Reilly PF; MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, UK., Oskarsson H; Humus, Reykjavik, Iceland., Owen MJ; MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Painter JN; Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Pedersen CB; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Centre for Integrated Register-Based Research, Aarhus University, Aarhus, Denmark.; National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark., Pedersen MG; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Centre for Integrated Register-Based Research, Aarhus University, Aarhus, Denmark.; National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark., Peterson RE; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.; Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA., Pettersson E; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Peyrot WJ; Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, The Netherlands., Pistis G; Department of Psychiatry, University Hospital of Lausanne, Prilly, Switzerland., Posthuma D; Complex Trait Genetics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Clinical Genetics, Vrije Universiteit Medical Center, Amsterdam, The Netherlands., Purcell SM; Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA., Quiroz JA; Solid Biosciences, Boston, MA, USA., Qvist P; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark., Rice JP; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Riley BP; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA., Rivera M; MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, UK.; Department of Biochemistry and Molecular Biology II, Institute of Neurosciences, Center for Biomedical Research, University of Granada, Granada, Spain., Saeed Mirza S; Epidemiology, Erasmus MC, Rotterdam, The Netherlands., Saxena R; Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA., Schoevers R; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Schulte EC; Department of Psychiatry and Psychotherapy, Medical Center of the University of Munich, Campus Innenstadt, Munich, Germany.; Institute of Psychiatric Phenomics and Genomics (IPPG), Medical Center of the University of Munich, Campus Innenstadt, Munich, Germany., Shen L; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA., Shi J; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Shyn SI; Behavioral Health Services, Kaiser Permanente Washington, Seattle, WA, USA., Sigurdsson E; Faculty of Medicine, Department of Psychiatry, University of Iceland, Reykjavik, Iceland., Sinnamon GBC; School of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia., Smit JH; Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, The Netherlands., Smith DJ; Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK., Stefansson H; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Steinberg S; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Stockmeier CA; Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA., Streit F; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Strohmaier J; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Tansey KE; College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK., Teismann H; Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Thompson W; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Capital Region of Denmark, Copenhagen, Denmark.; KG Jebsen Centre for Psychosis Research, Norway Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA., Thomson PA; Medical Genetics Section, CGEM, IGMM, University of Edinburgh, Edinburgh, UK., Thorgeirsson TE; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland., Tian C; Research, 23andMe, Inc., Mountain View, CA, USA., Traylor M; Clinical Neurosciences, University of Cambridge, Cambridge, UK., Treutlein J; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Trubetskoy V; Department of Psychiatry and Psychotherapy, Universitätsmedizin Berlin Campus Charité Mitte, Berlin, Germany., Uitterlinden AG; Internal Medicine, Erasmus MC, Rotterdam, The Netherlands., Umbricht D; Roche Pharmaceutical Research and Early Development, Neuroscience, Ophthalmology and Rare Diseases Discovery and Translational Medicine Area, Roche Innovation Center Basel, F. Hoffmann-La Roche, Ltd, Basel, Switzerland., Van der Auwera S; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., van Hemert AM; Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands., Viktorin A; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Visscher PM; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia., Wang Y; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Capital Region of Denmark, Copenhagen, Denmark.; KG Jebsen Centre for Psychosis Research, Norway Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Webb BT; Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA., Weinsheimer SM; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Capital Region of Denmark, Copenhagen, Denmark., Wellmann J; Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany., Willemsen G; Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Witt SH; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Wu Y; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Xi HS; Computational Sciences Center of Emphasis, Pfizer Global Research and Development, Cambridge, MA, USA., Yang J; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia., Zhang F; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Arolt V; Department of Psychiatry, University of Münster, Munster, Germany., Baune BT; Discipline of Psychiatry, University of Adelaide, Adelaide, South Australia, Australia., Berger K; Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany., Boomsma DI; Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Cichon S; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland.; Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany.; Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland., Dannlowski U; Department of Psychiatry, University of Münster, Munster, Germany., de Geus ECJ; Department of Biological Psychology and EMGO+ Institute for Health and Care Research, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Public Health Institute, Vrije Universiteit Medical Center, Amsterdam, The Netherlands., DePaulo JR; Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA., Domenici E; Centre for Integrative Biology, Università degli Studi di Trento, Trento, Italy., Domschke K; Department of Psychiatry and Psychotherapy, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Esko T; Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Estonian Genome Center, University of Tartu, Tartu, Estonia., Grabe HJ; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany., Hamilton SP; Psychiatry, Kaiser Permanente Northern California, San Francisco, CA, USA., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK., Heath AC; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Hinds DA; Research, 23andMe, Inc., Mountain View, CA, USA., Kendler KS; Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA., Kloiber S; Max Planck Institute of Psychiatry, Munich, Germany.; Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada., Lewis G; Division of Psychiatry, University College London, London, UK., Li QS; Neuroscience Therapeutic Area, Janssen Research and Development, LLC, Titusville, NJ, USA., Lucae S; Max Planck Institute of Psychiatry, Munich, Germany., Madden PFA; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, MO, USA., Magnusson PK; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Martin NG; Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., McIntosh AM; Division of Psychiatry, University of Edinburgh, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK., Metspalu A; Estonian Genome Center, University of Tartu, Tartu, Estonia.; Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia., Mors O; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Psychosis Research Unit, Aarhus University Hospital, Risskov, Aarhus, Denmark., Mortensen PB; iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Centre for Integrated Register-Based Research, Aarhus University, Aarhus, Denmark.; National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark., Müller-Myhsok B; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Institute of Translational Medicine, University of Liverpool, Liverpool, UK., Nordentoft M; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Mental Health Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark., Nöthen MM; Institute of Human Genetics, University of Bonn, Bonn, Germany.; Life & Brain Center, Department of Genomics, University of Bonn, Bonn, Germany., O'Donovan MC; MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK., Paciga SA; Human Genetics and Computational Biomedicine, Pfizer Global Research and Development, Groton, CT, USA., Pedersen NL; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Penninx BWJH; Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, The Netherlands., Perlis RH; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.; Psychiatry, Harvard Medical School, Boston, MA, USA., Porteous DJ; Medical Genetics Section, CGEM, IGMM, University of Edinburgh, Edinburgh, UK., Potash JB; Psychiatry, University of Iowa, Iowa City, IA, USA., Preisig M; Department of Psychiatry, University Hospital of Lausanne, Prilly, Switzerland., Rietschel M; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Schaefer C; Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA., Schulze TG; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.; Institute of Psychiatric Phenomics and Genomics (IPPG), Medical Center of the University of Munich, Campus Innenstadt, Munich, Germany.; Human Genetics Branch, NIMH Division of Intramural Research Programs, Bethesda, MD, USA.; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany., Smoller JW; Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.; Psychiatric and Neurodevelopmental Genetics Unit (PNGU), Massachusetts General Hospital, Boston, MA, USA., Stefansson K; deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Tiemeier H; Epidemiology, Erasmus MC, Rotterdam, The Netherlands.; Child and Adolescent Psychiatry, Erasmus MC, Rotterdam, The Netherlands.; Psychiatry, Erasmus MC, Rotterdam, The Netherlands., Uher R; Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada., Völzke H; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany., Weissman MM; Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA.; Division of Epidemiology, New York State Psychiatric Institute, New York, NY, USA., Werge T; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.; Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Capital Region of Denmark, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Winslow AR; Human Genetics and Computational Biomedicine, Pfizer Global Research and Development, Cambridge, MA, USA.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lewis CM; MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, UK.; Department of Medical and Molecular Genetics, King's College London, London, UK., Levinson DF; Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA., Breen G; MRC Social Genetic and Developmental Psychiatry Centre, King's College London, London, UK.; NIHR BRC for Mental Health, King's College London, London, UK., Børglum AD; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; iSEQ, Centre for Integrative Sequencing, Aarhus University, Aarhus, Denmark.; iPSYCH, Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark., Sullivan PF; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. pfsulliv@med.unc.edu.; Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. pfsulliv@med.unc.edu.; Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. pfsulliv@med.unc.edu.

Publikováno v: Nature genetics [Nat Genet] 2018 May; Vol. 50 (5), pp. 668-681. Date of Electronic Publication: 2018 Apr 26.