Exercise rescues obese mothers’ insulin sensitivity, placental hypoxia and male offspring insulin sensitivity

Autor: Fernandez Twinn, DS, Gascoin, G, Musial, B, Carr, S, Duque-Guimaraes, D, Blackmore, HL, Alfaradhi, MZ, Loche, E, Sferruzzi-Perri, AN, Fowden, AL, Ozanne, SE

Publikováno v: Scientific Reports.

The prevalence of obesity during pregnancy continues to increase at alarming rates. This is concerning as in addition to immediate impacts on maternal wellbeing, obesity during pregnancy has detrimental effects on the long-term health of the offsprin

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Effects of maternal diet-induced obesity on metabolic disorders and age-associated miRNA expression in the liver of male mouse offspring.

Autor: Mennitti LV; Department of Bioscience, Laboratory of Nutrition and Endocrine Physiology, Federal University of São Paulo, Santos, 11015-020, Brazil.; Metabolic Research Laboratories and MRC Metabolic Diseases Unit, University of Cambridge, Cambridge, CB2 OQQ, United Kingdom., Carpenter AAM; Metabolic Research Laboratories and MRC Metabolic Diseases Unit, University of Cambridge, Cambridge, CB2 OQQ, United Kingdom., Loche E; Metabolic Research Laboratories and MRC Metabolic Diseases Unit, University of Cambridge, Cambridge, CB2 OQQ, United Kingdom., Pantaleão LC; Metabolic Research Laboratories and MRC Metabolic Diseases Unit, University of Cambridge, Cambridge, CB2 OQQ, United Kingdom., Fernandez-Twinn DS; Metabolic Research Laboratories and MRC Metabolic Diseases Unit, University of Cambridge, Cambridge, CB2 OQQ, United Kingdom., Schoonejans JM; Metabolic Research Laboratories and MRC Metabolic Diseases Unit, University of Cambridge, Cambridge, CB2 OQQ, United Kingdom., Blackmore HL; Metabolic Research Laboratories and MRC Metabolic Diseases Unit, University of Cambridge, Cambridge, CB2 OQQ, United Kingdom., Ashmore TJ; Metabolic Research Laboratories and MRC Metabolic Diseases Unit, University of Cambridge, Cambridge, CB2 OQQ, United Kingdom., Pisani LP; Department of Bioscience, Laboratory of Nutrition and Endocrine Physiology, Federal University of São Paulo, Santos, 11015-020, Brazil.; Metabolic Research Laboratories and MRC Metabolic Diseases Unit, University of Cambridge, Cambridge, CB2 OQQ, United Kingdom., Tadross JA; Metabolic Research Laboratories and MRC Metabolic Diseases Unit, University of Cambridge, Cambridge, CB2 OQQ, United Kingdom.; Department of Pathology, University of Cambridge, Cambridge, CB2 1QP, United Kingdom., Hargreaves I; Department of Pharmacy and Biomolecular Science, Liverpool John Moores University, Byrom Street, Liverpool, L3 5UA, United Kingdom., Ozanne SE; Metabolic Research Laboratories and MRC Metabolic Diseases Unit, University of Cambridge, Cambridge, CB2 OQQ, United Kingdom. seo10@cam.ac.uk.

Publikováno v: International journal of obesity (2005) [Int J Obes (Lond)] 2022 Feb; Vol. 46 (2), pp. 269-278. Date of Electronic Publication: 2021 Oct 18.

Maternal diet-induced obesity during pregnancy alters lipid supply to mouse E18.5 fetuses and changes the cardiac tissue lipidome in a sex-dependent manner.

Autor: Pantaleão LC; Wellcome-MRC Institute of Metabolic Science and Medical Research Council Metabolic Diseases Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom., Inzani I; Wellcome-MRC Institute of Metabolic Science and Medical Research Council Metabolic Diseases Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom., Furse S; Wellcome-MRC Institute of Metabolic Science and Medical Research Council Metabolic Diseases Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.; Core Metabolomics and Lipidomics Laboratory, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke's Treatment Centre, Cambridge, United Kingdom., Loche E; Wellcome-MRC Institute of Metabolic Science and Medical Research Council Metabolic Diseases Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom., Hufnagel A; Wellcome-MRC Institute of Metabolic Science and Medical Research Council Metabolic Diseases Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom., Ashmore T; Wellcome-MRC Institute of Metabolic Science and Medical Research Council Metabolic Diseases Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom., Blackmore HL; Wellcome-MRC Institute of Metabolic Science and Medical Research Council Metabolic Diseases Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom., Jenkins B; Wellcome-MRC Institute of Metabolic Science and Medical Research Council Metabolic Diseases Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.; Core Metabolomics and Lipidomics Laboratory, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke's Treatment Centre, Cambridge, United Kingdom., Carpenter AAM; Wellcome-MRC Institute of Metabolic Science and Medical Research Council Metabolic Diseases Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom., Wilczynska A; Cancer Research UK Beatson Institute, Glasgow, United Kingdom.; Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom., Bushell M; Cancer Research UK Beatson Institute, Glasgow, United Kingdom.; Institute of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom., Koulman A; Wellcome-MRC Institute of Metabolic Science and Medical Research Council Metabolic Diseases Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.; Core Metabolomics and Lipidomics Laboratory, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke's Treatment Centre, Cambridge, United Kingdom., Fernandez-Twinn DS; Wellcome-MRC Institute of Metabolic Science and Medical Research Council Metabolic Diseases Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom., Ozanne SE; Wellcome-MRC Institute of Metabolic Science and Medical Research Council Metabolic Diseases Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.

Publikováno v: ELife [Elife] 2022 Jan 13; Vol. 11. Date of Electronic Publication: 2022 Jan 13.

Isolating adverse effects of glucocorticoids on the embryonic cardiovascular system.

Autor: Teulings NEWD; Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Garrud TAC; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Niu Y; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Skeffington KL; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Beck C; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Itani N; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Conlon FG; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Botting KJ; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Nicholas LM; Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Ashmore TJ; Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Blackmore HL; Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Tong W; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Camm EJ; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Derks JB; Department of Perinatal Medicine, University Medical Centre, Utrecht, Netherlands., Logan A; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK., Murphy MP; Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK., Ozanne SE; Institute of Metabolic Science-Metabolic Research Laboratories, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Giussani DA; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2020 Jul; Vol. 34 (7), pp. 9664-9677. Date of Electronic Publication: 2020 Jun 05.