Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression

Autor: Fursova, NA, Blackledge, NP, Nakayama, M, Ito, S, Koseki, Y, Farcas, AM, King, HW, Koseki, H, Klose, RJ

Publikováno v: Molecular Cell

Summary The Polycomb system modifies chromatin and plays an essential role in repressing gene expression to control normal mammalian development. However, the components and mechanisms that define how Polycomb protein complexes achieve this remain en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ebed6a1eb8ce4042e413f660be9575b9

The PNUTS phosphatase complex controls transcription pause release.

Autor: Kelley JR; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK., Dimitrova E; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK. Electronic address: emilia.dimitrova@bioch.ox.ac.uk., Maciuszek M; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK., Nguyen HT; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA., Szczurek AT; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK., Hughes AL; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK., Blackledge NP; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK., Kettenbach AN; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA; Dartmouth Cancer Center, Lebanon, NH 03756, USA., Klose RJ; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK. Electronic address: rob.klose@bioch.ox.ac.uk.

Publikováno v: Molecular cell [Mol Cell] 2024 Dec 19; Vol. 84 (24), pp. 4843-4861.e8. Date of Electronic Publication: 2024 Nov 26.

The Polycomb system sustains promoters in a deep OFF state by limiting pre-initiation complex formation to counteract transcription.

Autor: Szczurek AT; Department of Biochemistry, University of Oxford, Oxford, UK. aleksander.szczurek@bioch.ox.ac.uk., Dimitrova E; Department of Biochemistry, University of Oxford, Oxford, UK., Kelley JR; Department of Biochemistry, University of Oxford, Oxford, UK., Blackledge NP; Department of Biochemistry, University of Oxford, Oxford, UK., Klose RJ; Department of Biochemistry, University of Oxford, Oxford, UK. rob.klose@bioch.ox.ac.uk.

Publikováno v: Nature cell biology [Nat Cell Biol] 2024 Oct; Vol. 26 (10), pp. 1700-1711. Date of Electronic Publication: 2024 Sep 11.

A CpG island-encoded mechanism protects genes from premature transcription termination.

Autor: Hughes AL; Department of Biochemistry, University of Oxford, Oxford, UK., Szczurek AT; Department of Biochemistry, University of Oxford, Oxford, UK., Kelley JR; Department of Biochemistry, University of Oxford, Oxford, UK., Lastuvkova A; Department of Biochemistry, University of Oxford, Oxford, UK., Turberfield AH; Department of Biochemistry, University of Oxford, Oxford, UK., Dimitrova E; Department of Biochemistry, University of Oxford, Oxford, UK., Blackledge NP; Department of Biochemistry, University of Oxford, Oxford, UK., Klose RJ; Department of Biochemistry, University of Oxford, Oxford, UK. rob.klose@bioch.ox.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2023 Feb 09; Vol. 14 (1), pp. 726. Date of Electronic Publication: 2023 Feb 09.

Variant PCGF1-PRC1 links PRC2 recruitment with differentiation-associated transcriptional inactivation at target genes.

Autor: Sugishita H; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Cellular and Molecular Medicine, Advanced Research Departments, Graduate School of Medicine, Chiba University, Chiba, Japan.; International Research Center for Neurointelligence (IRCN), Institutes for Advanced Study, The University of Tokyo, Bunkyo-ku, Japan., Kondo T; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Ito S; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Nakayama M; Laboratory of Medical Omics Research, Kazusa DNA Research Institute, Kisarazu, Japan., Yakushiji-Kaminatsui N; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Kawakami E; Artificial Intelligence Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.; Healthcare and Medical Data Driven AI based Predictive Reasoning Development Unit, RIKEN Medical Sciences Innovation Hub Program, Yokohama, Japan., Koseki Y; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Cellular and Molecular Medicine, Advanced Research Departments, Graduate School of Medicine, Chiba University, Chiba, Japan., Ohinata Y; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Cellular and Molecular Medicine, Advanced Research Departments, Graduate School of Medicine, Chiba University, Chiba, Japan., Sharif J; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Harachi M; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Blackledge NP; Department of Biochemistry, University of Oxford, Oxford, UK., Klose RJ; Department of Biochemistry, University of Oxford, Oxford, UK., Koseki H; Laboratory for Developmental Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. haruhiko.koseki@riken.jp.; Cellular and Molecular Medicine, Advanced Research Departments, Graduate School of Medicine, Chiba University, Chiba, Japan. haruhiko.koseki@riken.jp.

Publikováno v: Nature communications [Nat Commun] 2021 Sep 09; Vol. 12 (1), pp. 5341. Date of Electronic Publication: 2021 Sep 09.