Exosome autoantibody biomarkers for detection of lung cancer.

Autor: Thuya WL; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore., Peyper JM; Sengenics Corporation, Jalan Kerinchi, Bangsar South, 59200, Kuala Lumpur, Malaysia.; University of Cape Town, Cape Town, 7700, South Africa., Myen TT; Sengenics Corporation, Jalan Kerinchi, Bangsar South, 59200, Kuala Lumpur, Malaysia., Anuar ND; Sengenics Corporation, Jalan Kerinchi, Bangsar South, 59200, Kuala Lumpur, Malaysia., Anwar A; Sengenics Corporation, Jalan Kerinchi, Bangsar South, 59200, Kuala Lumpur, Malaysia., Gudimella R; Sengenics Corporation, Jalan Kerinchi, Bangsar South, 59200, Kuala Lumpur, Malaysia., Rutt NH; Sengenics Corporation, Jalan Kerinchi, Bangsar South, 59200, Kuala Lumpur, Malaysia., Rosli NSM; Sengenics Corporation, Jalan Kerinchi, Bangsar South, 59200, Kuala Lumpur, Malaysia., Badri NH; Sengenics Corporation, Jalan Kerinchi, Bangsar South, 59200, Kuala Lumpur, Malaysia., Rahman TNA; Sengenics Corporation, Jalan Kerinchi, Bangsar South, 59200, Kuala Lumpur, Malaysia., Nurashirin R; Sengenics Corporation, Jalan Kerinchi, Bangsar South, 59200, Kuala Lumpur, Malaysia., Sethi G; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore.; NUS Centre for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117599, Singapore., Tam JKC; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 15 1E Kent Ridge Road, Singapore, 119228, Singapore., Wong AL; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore.; NUS Centre for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117599, Singapore.; Department of Haematology-Oncology, National University Cancer Institute, National 17 University Health System, Singapore, 119228, Singapore., Soo R; Department of Haematology-Oncology, National University Cancer Institute, National 17 University Health System, Singapore, 119228, Singapore., Blackburn JM; Sengenics Corporation, Jalan Kerinchi, Bangsar South, 59200, Kuala Lumpur, Malaysia.; University of Cape Town, Cape Town, 7700, South Africa., Wang L; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. csiwl@nus.edu.sg.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore. csiwl@nus.edu.sg.; NUS Centre for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117599, Singapore. csiwl@nus.edu.sg., Goh BC; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore. phcgbc@nus.edu.sg.; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117600, Singapore. phcgbc@nus.edu.sg.; NUS Centre for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117599, Singapore. phcgbc@nus.edu.sg.; Department of Haematology-Oncology, National University Cancer Institute, National 17 University Health System, Singapore, 119228, Singapore. phcgbc@nus.edu.sg.

Publikováno v: Military Medical Research [Mil Med Res] 2024 Nov 18; Vol. 11 (1), pp. 72. Date of Electronic Publication: 2024 Nov 18.

Multi-omics analysis of overexpressed tumor-associated proteins: gene expression, immunopeptide presentation, and antibody response in oropharyngeal squamous cell carcinoma, with a focus on cancer-testis antigens.

Autor: Abou Kors T; Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm, Germany., Meier M; Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm, Germany., Mühlenbruch L; Department of Immunology, Institute for Cell Biology, Eberhard Karls University of Tübingen, Tübingen, Germany.; Department of Peptide-based Immunotherapy, Eberhard Karls University and University Hospital Tübingen, Tübingen, Germany.; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.; German Cancer Consortium (DKTK), Partner Site Tübingen, Tübingen, Germany., Betzler AC; Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm, Germany.; Core Facility Immune Monitoring, Ulm University Medical Center, Ulm, Germany., Oliveri F; Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm, Germany., Bens M; Core Facility Next Generation Sequencing, Leibniz Institute on Aging - Fritz Lipmann Institute, Jena, Germany., Thomas J; Cancer Sciences Unit, University of Southampton, Faculty of Medicine, Southampton, United Kingdom., Kraus JM; Institute of Medical Systems Biology, Faculty of Medicine, Ulm University, Ulm, Germany., Doescher J; Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm, Germany.; Department of Otolaryngology, Augsburg University Hospital, Augsburg, Germany., von Witzleben A; Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm, Germany., Hofmann L; Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm, Germany., Ezic J; Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm, Germany., Huber D; Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm, Germany., Benckendorff J; Institute of Pathology, Ulm University Medical Center, Ulm, Germany., Barth TFE; Institute of Pathology, Ulm University Medical Center, Ulm, Germany., Greve J; Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm, Germany., Schuler PJ; Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm, Germany.; Surgical Oncology Ulm, i2SOUL Consortium, Ulm, Germany., Brunner C; Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm, Germany.; Core Facility Immune Monitoring, Ulm University Medical Center, Ulm, Germany., Blackburn JM; Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Hoffmann TK; Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm, Germany.; Surgical Oncology Ulm, i2SOUL Consortium, Ulm, Germany., Ottensmeier C; Institute of Systems, Molecular and Integrative Biology, Liverpool Head and Neck Center, University of Liverpool, Faculty of Medicine, Liverpool, United Kingdom., Kestler HA; Institute of Medical Systems Biology, Faculty of Medicine, Ulm University, Ulm, Germany.; Surgical Oncology Ulm, i2SOUL Consortium, Ulm, Germany., Rammensee HG; Department of Immunology, Institute for Cell Biology, Eberhard Karls University of Tübingen, Tübingen, Germany.; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.; German Cancer Consortium (DKTK), Partner Site Tübingen, Tübingen, Germany., Walz JS; Department of Peptide-based Immunotherapy, Eberhard Karls University and University Hospital Tübingen, Tübingen, Germany.; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.; German Cancer Consortium (DKTK), Partner Site Tübingen, Tübingen, Germany.; Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany., Laban S; Department of Otorhinolaryngology and Head and Neck Surgery, Ulm University Medical Center, Ulm, Germany.; Surgical Oncology Ulm, i2SOUL Consortium, Ulm, Germany.

Publikováno v: Frontiers in immunology [Front Immunol] 2024 Jul 29; Vol. 15, pp. 1408173. Date of Electronic Publication: 2024 Jul 29 (Print Publication: 2024).

Humoral immunoprofiling identifies novel biomarkers and an immune suppressive autoantibody phenotype at the site of disease in pancreatic ductal adenocarcinoma.

Autor: Maimela PWM; Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Smith M; Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Nel AJM; Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Bernam SDP; Sengenics Corporation, Kuala Lumpur, Malaysia., Jonas EG; Department of Surgery, Gastroenterology Unit, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa., Blackburn JM; Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.; Sengenics Corporation, Kuala Lumpur, Malaysia.; Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Publikováno v: Frontiers in oncology [Front Oncol] 2024 Feb 21; Vol. 14, pp. 1330419. Date of Electronic Publication: 2024 Feb 21 (Print Publication: 2024).

Bifidobacterium infantis associates with T cell immunity in human infants and is sufficient to enhance antigen-specific T cells in mice.

Autor: Nyangahu DD; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA., Happel AU; Institute of Infectious Diseases and Molecular Medicine, Department of Pathology, Division of Immunology, University of Cape Town, Cape Town, South Africa., Wendoh J; Institute of Infectious Diseases and Molecular Medicine, Department of Pathology, Division of Immunology, University of Cape Town, Cape Town, South Africa., Kiravu A; Institute of Infectious Diseases and Molecular Medicine, Department of Pathology, Division of Immunology, University of Cape Town, Cape Town, South Africa., Wang Y; Department of Bioengineering, University of Washington, Seattle, WA, USA., Feng C; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA., Plumlee C; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA., Cohen S; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA., Brown BP; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA., Djukovic D; Northwest Metabolomics Research Center, University of Washington, Seattle, WA, USA., Ganief T; Institute of Infectious Diseases and Molecular Medicine, Department of Integrative Biomedical Sciences, Division of Chemical and Systems Biology, University of Cape Town, Cape Town, South Africa., Gasper M; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA., Raftery D; Northwest Metabolomics Research Center, University of Washington, Seattle, WA, USA., Blackburn JM; Institute of Infectious Diseases and Molecular Medicine, Department of Integrative Biomedical Sciences, Division of Chemical and Systems Biology, University of Cape Town, Cape Town, South Africa., Allbritton NL; Department of Bioengineering, University of Washington, Seattle, WA, USA., Gray CM; Institute of Infectious Diseases and Molecular Medicine, Department of Pathology, Division of Immunology, University of Cape Town, Cape Town, South Africa.; Biomedical Research Institute, Division of Molecular Biology and Human Genetics, Stellenbosch University, Cape Town, South Africa., Paik J; Department of Comparative Medicine, University of Washington, Seattle, WA, USA., Urdahl KB; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.; Department of Pediatrics, School of Medicine, University of Washington, Seattle WA, USA., Jaspan HB; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, USA.; Institute of Infectious Diseases and Molecular Medicine, Department of Pathology, Division of Immunology, University of Cape Town, Cape Town, South Africa.; Department of Pediatrics, School of Medicine, University of Washington, Seattle WA, USA.

Publikováno v: Science advances [Sci Adv] 2023 Dec 08; Vol. 9 (49), pp. eade1370. Date of Electronic Publication: 2023 Dec 08.

Auto-immunoproteomics analysis of COVID-19 ICU patients revealed increased levels of autoantibodies related to the male reproductive system.

Autor: Schmidt F; Proteomics Core, Weill Cornell Medicine-Qatar, Doha, Qatar., Abdesselem HB; Proteomics Core Facility, Qatar Biomedical Research Institute (QBRI), Qatar Foundation, Hamad Bin Khalifa University (HBKU), Doha, Qatar.; Neurological Disorders Research Center, QBRI, HBKU, Qatar Foundation, Doha, Qatar., Suhre K; Bioinformatics Core, Weill Cornell Medicine-Qatar, Doha, Qatar., Vaikath NN; Neurological Disorders Research Center, QBRI, HBKU, Qatar Foundation, Doha, Qatar., Sohail MU; Proteomics Core, Weill Cornell Medicine-Qatar, Doha, Qatar., Al-Nesf M; Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.; Center of Metabolism and Inflammation, Division of Medicine, University College London, London, United Kingdom., Bensmail I; Proteomics Core Facility, Qatar Biomedical Research Institute (QBRI), Qatar Foundation, Hamad Bin Khalifa University (HBKU), Doha, Qatar., Mashod F; Proteomics Core, Weill Cornell Medicine-Qatar, Doha, Qatar., Sarwath H; Proteomics Core, Weill Cornell Medicine-Qatar, Doha, Qatar., Bernhardt J; Institute for Microbiology, University of Greifswald, Greifswald, Germany., Schaefer-Ramadan S; Department of Genomic Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar., Tan TM; Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.; Sengenics Corporation, Damansara Heights, Kuala Lumpur, Malaysia.; Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Morris PE; Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.; Sengenics Corporation, Damansara Heights, Kuala Lumpur, Malaysia.; Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Schenck EJ; Department of Medicine, Division of Pulmonary and Critical Care Medicine, New York Presbyterian Hospital-Weill Cornell Medical Center, Weill Cornell Medicine, New York, NY, United States., Price D; Department of Medicine, Division of Pulmonary and Critical Care Medicine, New York Presbyterian Hospital-Weill Cornell Medical Center, Weill Cornell Medicine, New York, NY, United States., Mohamed-Ali V; Center of Metabolism and Inflammation, Division of Medicine, University College London, London, United Kingdom.; Anti-Doping Laboratory Qatar, Doha, Qatar., Al-Maadheed M; Center of Metabolism and Inflammation, Division of Medicine, University College London, London, United Kingdom.; Anti-Doping Laboratory Qatar, Doha, Qatar., Arredouani A; Diabetes Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar.; College of Health and Life Sciences, Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar., Decock J; College of Health and Life Sciences, Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar.; Translational Cancer and Immunity Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar., Blackburn JM; Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.; Sengenics Corporation, Damansara Heights, Kuala Lumpur, Malaysia.; Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Choi AMK; Department of Medicine, Division of Pulmonary and Critical Care Medicine, New York Presbyterian Hospital-Weill Cornell Medical Center, Weill Cornell Medicine, New York, NY, United States., El-Agnaf OM; Neurological Disorders Research Center, QBRI, HBKU, Qatar Foundation, Doha, Qatar.

Publikováno v: Frontiers in physiology [Front Physiol] 2023 Jul 14; Vol. 14, pp. 1203723. Date of Electronic Publication: 2023 Jul 14 (Print Publication: 2023).