Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Black, Regina M."'
Autor:
Richard G. Ball, Sheila M. Galloway, Katherine K. McGettigan, Harvey R. Wendt, Gregori J. Morriello, Jerry Di Salvo, Marat Vijay Reddy, Black Regina M, Amanda L. Hurley, Judy Morris, Scott D. Feighner, Eric Streckfuss, George A. Doss, Alka Bansal, Anthony Sanfiz, Scott D. Edmondson, Mary Struthers, Nancy N. Tsou, Jiafang He, Crystal McKnight, George M. Laws, Donna L. Hreniuk, Gino Salituro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:1865-1870
A novel class of human β(3)-adrenergic receptor agonists was designed in effort to improve selectivity and metabolic stability versus previous disclosed β(3)-AR agonists. As observed, many of the β(3)-AR agonists seem to need the acyclic ethanolam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f6c8507b7efbb2f70d1c735a63653c9
https://doi.org/10.1016/j.bmcl.2010.12.087
https://doi.org/10.1016/j.bmcl.2010.12.087
Autor:
George N. Nikov, Grace Bi, Benito Munoz, Matthew G. Stanton, Matthew T. Tudge, Richard E. Middleton, Jamie L. Crispino, Peter Sajonz, Mark S. Shearman, Black Regina M, Minilik Angagaw, Paula Andrade, Eric Fan, Flobert Tanga, Jonathan C. Cruz, Alexander A. Szewczak, Nirah H. Shomer, Bethany Hughes, Sanjiv J. Shah, Georgia Farris, Christopher Hamblett, Jed L. Hubbs, David L. Sloman, Candia M. Kenific
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:755-758
We report herein a novel series of difluoropiperidine acetic acids as modulators of gamma-secretase. Synthesis of 2-aryl-3,3-difluoropiperidine analogs was facilitated by a unique and selective beta-difluorination with Selectfluor. Compounds 1f and 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7392b77aec791c32df48952dbb130dde
https://doi.org/10.1016/j.bmcl.2009.11.034
https://doi.org/10.1016/j.bmcl.2009.11.034
Autor:
Sarah Dreikorn, Ken Bartizal, George K. Abruzzo, Black Regina M, K Nollstadt, James M. Balkovec
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2879-2884
A series of pneumocandin B 0 analogs substituted at the 3′ -position of the homotyrosine (Hty) residue have been prepared and evaluated for their inhibition of 1,3-β-( d )-glucan synthesis and for their antifungal activity against C. albicans . Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6004339d7e31e9ad14587434da882b63
https://doi.org/10.1016/s0960-894x(97)10107-x
https://doi.org/10.1016/s0960-894x(97)10107-x
Autor:
Daniel B. Eddings, Nikolay Gerasimchuk, Christopher J. Welch, Abigail Albright, Black Regina M, Robert E. Gawley
Publikováno v:
The Journal of organic chemistry. 76(18)
Chiral, C(2)-symmetric imidazolium and imidazolinium ions, as well as the corresponding copper- or silver-bound carbenoids, have been prepared. Structural study of these compounds by X-ray crystallography reveals a chiral pocket that surrounds the pu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf7323158ba038c02c782d563db8320
https://pubmed.ncbi.nlm.nih.gov/21823580
https://pubmed.ncbi.nlm.nih.gov/21823580
Autor:
Nollstadt Karl, Ken Bartizal, Black Regina M, Sarah Dreikorn, George K. Abruzzo, James M. Balkovec
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:2039-2042
Pneumocandin B 0 1 undergoes selective oxidation / reduction chemistry at the homotyrosine ( hty ) residue. Removal of the phenolic hydroxyl gives >140-fold loss in activity against a Candida albicans 1,3-β-glucan synthetase enzyme preparation and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c79859a14bf21da5e47a77aeee8808c6
https://doi.org/10.1016/s0960-894x(01)81010-6
https://doi.org/10.1016/s0960-894x(01)81010-6
Autor:
James M. Balkovec, George K. Abruzzo, Ken Bartizal, Black Regina M, Sarah Dreikorn, K Nollstadt
Publikováno v:
ChemInform. 29
A series of pneumocandin B 0 analogs substituted at the 3′ -position of the homotyrosine (Hty) residue have been prepared and evaluated for their inhibition of 1,3-β-( d )-glucan synthesis and for their antifungal activity against C. albicans . Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d08082108c690c2847b01e79b5b50d0f
https://doi.org/10.1002/chin.199810219
https://doi.org/10.1002/chin.199810219
Autor:
Black Regina M, James M. Balkovec
Publikováno v:
Tetrahedron Letters. 33:4529-4532
Sodium cyanoborohydride in trifluoroacetic acid selectively reduced the C5-orn and C4-htyr carbinols to methylene groups in echinocandin lipopeptides. The selective reduction of either hydroxyl is also described. The first conversion of echinocandin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fc056e14e466d69a20b04205b16238c
https://doi.org/10.1016/s0040-4039(00)61304-7
https://doi.org/10.1016/s0040-4039(00)61304-7
Autor:
Morriello, Gregori J., Wendt, Harvey R., Bansal, Alka, Salvo, Jerry Di, Feighner, Scott, He, Jiafang, Hurley, Amanda L., Hreniuk, Donna L., Salituro, Gino M., Reddy, Marat Vijay, Galloway, Sheila M., McGettigan, Katherine K., Laws, George, McKnight, Crystal, Doss, George A., Tsou, Nancy N., Black, Regina M., Morris, Judy, Ball, Richard G., Sanfiz, Anthony T., Streckfuss, Eric, Struthers, Mary, Edmondson, Scott D.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2011 21(6):1865-1870
Autor:
Thomas W. Doebber, Black Regina M, John J. Acton, Joel P. Berger, David E. Moller, Karen L. MacNaul, Lawrence F. Colwell, Harold B. Wood, A. Brian Jones
Publikováno v:
ChemInform. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49b8e7c3286198c7fc7b131a6ac86881
https://doi.org/10.1002/chin.200521117
https://doi.org/10.1002/chin.200521117
Autor:
A. Brian Jones, Kun Liu, Black Regina M, Cherrie Liu, Ralph T. Mosley, Richard Tschirret-Guth, Margaret E. McCann, John J. Acton, Joel P. Berger, Peter T. Meinke, Meng Yang, Lawrence F. Colwell, Sheryl D. Debenham, Harold B. Wood, Chuanlin F. Wang, Ramon Abola, Margaret Wu, David E. Moller, Karen L. MacNaul
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(10)
A series of metabolically robust N-benzyl-indole selective PPARgamma modulators with either a 3-benzoyl or 3-benzisoxazoyl moiety have been identified. In vitro, these compounds are partial agonists and exhibit reduced adipogenesis in human adipocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eafc8584a178c07253f64ca73f9967a
https://pubmed.ncbi.nlm.nih.gov/15863293
https://pubmed.ncbi.nlm.nih.gov/15863293