Exploration of the tunability of BRD4 degradation by DCAF16 trans-labelling covalent glues.

Autor: Hassan MM; Department of Chemical and Systems Biology, ChEM-H and Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, CA, USA; SPARK Translational Research Program, Stanford University School of Medicine, Stanford, CA, USA., Li YD; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ma MW; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Teng M; Center for Drug Discovery, Department of Pathology & Immunology, and Verna and Marrs McLean Department of Biochemistry and Molecular Pharmacology, Baylor College of Medicine, Houston, TX, USA., Byun WS; Department of Chemical and Systems Biology, ChEM-H and Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, CA, USA., Puvar K; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Lumpkin R; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Sandoval B; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Rutter JC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Jin CY; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Wang MY; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Xu S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Schmoker AM; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Cheong H; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Groendyke BJ; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Qi J; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Fischer ES; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. Electronic address: eric_fischer@dfci.harvard.edu., Ebert BL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Howard Hughes Medical Institute, Boston, MA, USA. Electronic address: benjamin_ebert@dfci.harvard.edu., Gray NS; Department of Chemical and Systems Biology, ChEM-H and Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, CA, USA. Electronic address: nsgray01@stanford.edu.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2024 Dec 05; Vol. 279, pp. 116904. Date of Electronic Publication: 2024 Sep 24.

Genetic risk classification for adults with AML receiving less-intensive therapies: the 2024 ELN recommendations.

Autor: Döhner H; Department of Internal Medicine III, Ulm University Hospital, Ulm, Germany., DiNardo CD; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX., Appelbaum FR; Division of Hematology and Oncology, University of Washington and Fred Hutchinson Cancer Research Center, Seattle, WA., Craddock C; University of Warwick Trials Unit, Centre for Clinical Haematology, Queen Elizabeth Hospital, Birmingham, United Kingdom., Dombret H; Department of Hematology, Saint-Louis Institute for Research, Université Paris Cité, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France., Ebert BL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Fenaux P; Service d'Hématologie Séniors, Hôpital Saint-Louis, Assistance Publique des Hôpitaux de Paris and Université de Paris Cité, Paris, France., Godley LA; Division of Hematology/Oncology, Department of Medicine, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL., Hasserjian RP; Department of Pathology, Massachusetts General Hospital, Boston, MA., Larson RA; Department of Medicine and Comprehensive Cancer Center, The University of Chicago, Chicago, IL., Levine RL; Department of Medicine, Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY., Miyazaki Y; Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan., Niederwieser D; Division of Hematology and Medical Oncology, University of Leipzig, Leipzig, Germany., Ossenkoppele G; Department of Hematology, Amsterdam University Medical Center, Location Vrije Universiteit Medical Center, Amsterdam, The Netherlands., Röllig C; Department of Internal Medicine I, University Hospital Carl Gustav Carus TU Dresden, Dresden, Germany., Sierra J; Hematology Department, Hospital Santa Creu i Sant Pau, Barcelona, Spain., Stein EM; Department of Medicine, Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY., Tallman MS; Department of Medicine, Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY., Tien HF; Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Wang J; Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China., Wierzbowska A; Department of Hematology, Medical University of Lodz, Lodz, Poland., Wei AH; Department of Haematology, Peter MacCallum Cancer Centre, The Royal Melbourne Hospital and The University of Melbourne, Melbourne, Australia., Löwenberg B; Department of Hematology, Erasmus University Medical Center Rotterdam and Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

Publikováno v: Blood [Blood] 2024 Nov 21; Vol. 144 (21), pp. 2169-2173.

JAK2-mutant clonal hematopoiesis is associated with venous thromboembolism.

Autor: Zon RL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA., Sekar A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA., Clapham K; Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT., Oren O; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA.; Division of Cardiology, Massachusetts General Hospital, Boston, MA., Niroula A; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA.; Institute of Biomedicine, SciLifeLab, University of Gothenburg, Gothenburg, Sweden., Bick AG; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN., Gibson CJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA., Griffin G; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA., Uddin MM; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA., Neuberg D; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA., Natarajan P; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA., Ebert BL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA.; Howard Hughes Medical Institute, Dana-Farber Cancer Institute, Boston, MA.

Publikováno v: Blood [Blood] 2024 Nov 14; Vol. 144 (20), pp. 2149-2154.

Author Correction: Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9.

Autor: Schneider RK; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Department of Hematology, Hemostaseology, Oncology and Stem Cell Transplantation, University Hospital Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen, Aachen, Germany., Schenone M; Broad Institute of Harvard University and the Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Ferreira MV; Department of Hematology, Hemostaseology, Oncology and Stem Cell Transplantation, University Hospital Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen, Aachen, Germany., Kramann R; Renal Division, Brigham and Women's Hospital, Boston, Massachusetts, USA., Joyce CE; Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Hartigan C; Broad Institute of Harvard University and the Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Beier F; Department of Hematology, Hemostaseology, Oncology and Stem Cell Transplantation, University Hospital Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen, Aachen, Germany., Brümmendorf TH; Department of Hematology, Hemostaseology, Oncology and Stem Cell Transplantation, University Hospital Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen, Aachen, Germany., Germing U; Department of Hematology, Oncology and Clinical Immunology, Heinrich Heine University, Düsseldorf, Germany., Platzbecker U; Department of Medicine I, University Hospital Carl Gustav Carus, University of Technology, Dresden, Germany., Büsche G; Institute of Pathology, Hannover Medical School, Hannover, Germany., Knüchel R; Institute of Pathology, University Hospital Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen, Aachen, Germany., Chen MC; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Waters CS; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Chen E; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Chu LP; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Novina CD; Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Lindsley RC; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.; Dana-Farber Cancer Institute, Boston, Massachusetts, USA., Carr SA; Department of Hematology, Hemostaseology, Oncology and Stem Cell Transplantation, University Hospital Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen, Aachen, Germany., Ebert BL; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. bebert@partners.org.; Broad Institute of Harvard University and the Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. bebert@partners.org.

Publikováno v: Nature medicine [Nat Med] 2024 Nov; Vol. 30 (11), pp. 3382.

Human Plasma Proteomic Profile of Clonal Hematopoiesis.

Autor: Yu Z; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Vromman A; Cardiovascular Division, Brigham and Women's Hospital Heart & Vascular Center, Boston, MA, USA., Nguyen NQH; Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Schuermans A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Rentz T; Cardiovascular Division, Brigham and Women's Hospital Heart & Vascular Center, Boston, MA, USA., Vellarikkal SK; Cardiovascular Division, Brigham and Women's Hospital Heart & Vascular Center, Boston, MA, USA., Uddin MM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Niroula A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Laboratory Medicine, Lund University, Lund, Sweden., Griffin G; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Department of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA., Honigberg MC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Lin AE; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Division, Brigham and Women's Hospital Heart & Vascular Center, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Gibson CJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Katz DH; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Department of Cardiovascular Medicine, Stanford University, Stanford, CA, USA., Tahir U; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Fang S; Cardiovascular Division, Brigham and Women's Hospital Heart & Vascular Center, Boston, MA, USA., Haidermota S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Ganesh S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Antoine T; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Weinstock J; Department of Genetics, Stanford University, Stanford, CA, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA., Austin TR; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Ramachandran VS; Department of Medicine, School of Medicine, Boston University, Boston, MA, USA.; Framingham Heart Study, Framingham, MA, USA., Peloso GM; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Hornsby W; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Ganz P; Division of Cardiology, Zuckerberg San Francisco General Hospital and Department of Medicine, University of California, San Francisco, CA, USA., Manson JE; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Haring B; Department of Medicine III, Saarland University Hospital, Homburg, Germany.; Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Kooperberg CL; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Reiner AP; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.; Department of Health Systems and Population Health, University of Washington, Seattle, WA, USA., Bis JC; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.; Department of Medicine, University of Washington, Seattle, WA, USA., Psaty BM; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Systems and Population Health, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA., Min YI; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Lange LA; Department of Medicine, Division of Biomedical Informatics and Personalized Medicine, University of Colorado Anschutz Medical Campus, Denver, CO, USA., Post WS; Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Wilson JG; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Ebert BL; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Yu B; Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Ballantyne CM; Department of Medicine, Baylor College of Medicine, Houston, TX, USA., Coresh J; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Sankaran VG; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Hematology and Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA., Bick AG; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Jaiswal S; Department of Pathology and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA., Gerszten RE; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Libby P; Cardiovascular Division, Brigham and Women's Hospital Heart & Vascular Center, Boston, MA, USA., Gupta RM; Cardiovascular Division, Brigham and Women's Hospital Heart & Vascular Center, Boston, MA, USA., Natarajan P; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Oct 31. Date of Electronic Publication: 2024 Oct 31.