Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Bjorn Vergauwen"'
Autor:
Jan Felix, Eaazhisai Kandiah, Steven De Munck, Yehudi Bloch, Gydo C.P. van Zundert, Kris Pauwels, Ann Dansercoer, Katka Novanska, Randy J. Read, Alexandre M.J.J. Bonvin, Bjorn Vergauwen, Kenneth Verstraete, Irina Gutsche, Savvas N. Savvides
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Viruses often subvert the host immune system using molecular decoys to prevent an effective immune response. Here, the authors examine the structural details of the viral decoy receptor GIF and its antagnosim of GM-CSF and IL-2.
Externí odkaz:
https://doaj.org/article/1a41664ed7484e5ea4bc536b02b76f4a
Autor:
Bjorn Vergauwen, Robin Koekoekx, Marwa F. Mansour, Guy Van den Mooter, Bart Smeets, Ann Van Schepdael, Timothy Pas, Herman Ramon, Christian Clasen
Publikováno v:
Molecular Pharmaceutics. 17:2987-2999
In this study, we report on the influence of mechanochemical activation on the chemical stability of amorphous solid dispersions made up of indomethacin and hydroxypropyl methyl cellulose (HPMC), poly(vinylpyrrolidone) (PVP), poly(vinylpyrrolidone vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a521240bd047ef01b62ccd9eb2b5080
https://doi.org/10.1021/acs.molpharmaceut.0c00376
https://doi.org/10.1021/acs.molpharmaceut.0c00376
Publikováno v:
Rapid Communications in Mass Spectrometry. 34
Rationale It is important to investigate the behavior of protein hydrolysate components in both in vitro and in vivo studies, to support the elucidation of their biological functions. As protein hydrolysates and biological matrices are highly complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1db54f544653c3d4f26ed2fb9d9485
https://doi.org/10.1002/rcm.8934
https://doi.org/10.1002/rcm.8934
Autor:
Robin Koekoekx, Emiel Michiels, Guy Van den Mooter, Timothy Pas, Bjorn Vergauwen, Joost Schymkowitz, Christian Clasen, Frederic Rousseau, Alessandra Bergonzi
Publikováno v:
Molecular pharmaceutics. 17(3)
In this work, a chemical (and physical) evaluation of cryogenic milling to manufacture amorphous solid dispersions (ASDs) is provided to support novel mechanistic insights in the cryomilling process. Cryogenic milling devices are considered as reacto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04daaca255c6a51b9298f49eb3b584fe
https://pubmed.ncbi.nlm.nih.gov/31961692
https://pubmed.ncbi.nlm.nih.gov/31961692
Publikováno v:
Journal of Microbiological Methods. 132:153-159
Bacterial endotoxins have high immunogenicity. Phage biology studies as well as therapeutic phage applications necessitate highly purified phage particles. In this study, we compared combinations of seven different endotoxin removal strategies and va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fcba49b58c1e020d3d71483b73e547d
https://doi.org/10.1016/j.mimet.2016.11.020
https://doi.org/10.1016/j.mimet.2016.11.020
Publikováno v:
International journal of pharmaceutics. 563
In order to further explain the ability of gelatin 50PS and bovine serum albumin (BSA) to generate supersaturation of a series of poorly soluble drugs (carbamazepine, cinnarizine, diazepam, itraconazole, nifedipine, indomethacin, darunavir (ethanolat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5c2ab4b24079333af9408a2bfc35f4
https://pubmed.ncbi.nlm.nih.gov/30935916
https://pubmed.ncbi.nlm.nih.gov/30935916
Autor:
Thomas De Schryver, Marijn Boone, Barbara Duquenne, Luc Van Hoorebeke, Jan De Block, Bjorn Vergauwen, Stephanie Van Weyenberg, Claude Capdepon, Paul Stevens
Publikováno v:
Food Hydrocolloids. 60:317-323
The effect of low molecular weight gelatin peptides on the shrinkage of thawed mousses was investigated. Changes promoted by freezing-thawing processes were evaluated through texture and volume measurements and through X-ray analysis of the bubble di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::603512aea18720a6836515a0be92f886
https://doi.org/10.1016/j.foodhyd.2016.04.001
https://doi.org/10.1016/j.foodhyd.2016.04.001
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 178:112937
Amorphous solid dispersions (ASDs) are single-phase amorphous systems, where drug molecules are molecularly dispersed (dissolved) in a polymer matrix. The molecular dispersion of the drug molecules is responsible for their improved dissolution proper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8881369f6c02ae4e93135ed03949de05
https://doi.org/10.1016/j.jpba.2019.112937
https://doi.org/10.1016/j.jpba.2019.112937
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 131
Gelatin and bovine serum albumin (BSA), two readily available biopolymers, were examined for their effect on solubility and supersaturation of drugs because of their capacity to interact with drugs (e.g. via hydrogen bonding, van der Waals or electro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd22fa575c509a69794bd7f1c4efd5e
https://pubmed.ncbi.nlm.nih.gov/30121247
https://pubmed.ncbi.nlm.nih.gov/30121247