Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Bjorn R. van Doodewaerd"'
1
Akademický článek
Neutron-encoded diubiquitins to profile linkage selectivity of deubiquitinating enzymes
Autor: Bianca D. M. van Tol, Bjorn R. van Doodewaerd, Guinevere S. M. Lageveen-Kammeijer, Bas C. Jansen, Cami M. P. Talavera Ormeño, Paul J. M. Hekking, Aysegul Sapmaz, Robbert Q. Kim, Angeliki Moutsiopoulou, David Komander, Manfred Wuhrer, Gerbrand J. van der Heden van Noort, Huib Ovaa, Paul P. Geurink
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Most insights into deubiquitinase (DUB) substrate specificity originate from studies with isolated di-ubiquitins (diUb), but in cells diUbs with different linkage types coexist. Here, the authors develop a mass spectrometric DUB activity assay that c
Externí odkaz: https://doaj.org/article/2c3b7930e79a4065a586ae1d307ad567
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2
Akademický článek
Encapsulation of SAAP-148 in Octenyl Succinic Anhydride-Modified Hyaluronic Acid Nanogels for Treatment of Skin Wound Infections
Autor: Miriam E. van Gent, Tom van Baaren, Sylvia N. Kłodzińska, Muhanad Ali, Natasja Dolezal, Bjorn R. van Doodewaerd, Erik Bos, Amy M. de Waal, Roman I. Koning, Jan Wouter Drijfhout, Hanne Mørck Nielsen, Peter H. Nibbering
Publikováno v: Pharmaceutics, Vol 15, Iss 2, p 429 (2023)
Chronic wound infections colonized by bacteria are becoming more difficult to treat with current antibiotics due to the development of antimicrobial resistance (AMR) as well as biofilm and persister cell formation. Synthetic antibacterial and antibio
Externí odkaz: https://doaj.org/article/b518551780ec46efb7e3e99e2e77ddab
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3
Physical and functional characterization of PLGA nanoparticles containing the antimicrobial peptide SAAP-148
Autor: Muhanad Ali, Miriam E. van Gent, Amy M. de Waal, Bjorn R. van Doodewaerd, Erik Bos, Roman I. Koning, Robert A. Cordfunke, Jan Wouter Drijfhout, Peter H. Nibbering
Publikováno v: International Journal of Molecular Sciences, 24(3). MDPI
International Journal of Molecular Sciences
Volume 24
Issue 3
Pages: 2867
Synthetic antimicrobial and antibiofilm peptide (SAAP-148) commits significant antimicrobial activities against antimicrobial resistant (AMR) planktonic bacteria and biofilms. However, SAAP-148 is limited by its low selectivity index, i.e., ratio bet
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::910d7b1929e272777a12d60c1a24a60e
http://hdl.handle.net/1887/3570855
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5
The alkyne moiety as a latent electrophile in irreversible covalent small molecule inhibitors of Cathepsin K
Autor: Jure Loboda, Huib Ovaa, Elma Mons, Jill Hermans, Martijn Verdoes, Peter A. van Veelen, Boris Turk, Ineke D. C. Jansen, Dušan Turk, Bjorn R. van Doodewaerd, Constant A. A. van Boeckel
Publikováno v: Journal of the American Chemical Society, 141(8), 3507-3514. American Chemical Society
Journal of the American Chemical Society
Mons, E, Jansen, I D C, Loboda, J, van Doodewaerd, B R, Hermans, J, Verdoes, M, van Boeckel, C A A, van Veelen, P A, Turk, B, Turk, D & Ovaa, H 2019, ' The alkyne moiety as a latent electrophile in irreversible covalent small molecule inhibitors of Cathepsin K ', Journal of the American Chemical Society, vol. 141, no. 8, pp. 3507-3514 . https://doi.org/10.1021/jacs.8b11027
Journal of the American Chemical Society, 141, 8, pp. 3507-3514
Journal of the American Chemical Society, 141, 3507-3514
Journal of the American Chemical Society, 141(8), 3507-3514
Irreversible covalent inhibitors can have a beneficial pharmacokinetic/pharmacodynamics profile but are still often avoided due to the risk of indiscriminate covalent reactivity and the resulting adverse effects. To overcome this potential liability,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34621c0b43c4eedbb885bb9f31641ab6
https://dare.uva.nl/personal/pure/en/publications/the-alkyne-moiety-as-a-latent-electrophile-in-irreversible-covalent-small-molecule-inhibitors-of-cathepsin-k(c6648de6-11fb-4e6e-b618-732d075f73d1).html
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6
Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling
Autor: Nicholas R. Casewell, Julien Slagboom, Jeroen C. Visser, Ryan J. R. McCleary, Fernanda C. Cardoso, Jeroen Kool, August B. Smit, Bjorn R. van Doodewaerd, Janaki Krishnamoorthy Iyer, Govert W. Somsen, Reka A. Otvos, Richard J. Lewis, Wilfried M. A. Niessen, R. Manjunatha Kini
Publikováno v: Slagboom, J, Otvos, R A, Cardoso, F C, Iyer, J, Visser, J C, van Doodewaerd, B R, McCleary, R J R, Niessen, W M A, Somsen, G W, Lewis, R J, Kini, R M, Smit, A B, Casewell, N R & Kool, J 2018, ' Neurotoxicity fingerprinting of venoms using
microfluidic AChBP profiling ', Toxicon, vol. 148, pp. 213-222 . https://doi.org/10.1016/j.toxicon.2018.04.022
Toxicon, 148, 213-222. Elsevier Limited
Venoms from snakes are rich sources of highly active proteins with potent affinity towards a variety of enzymes and receptors. Of the many distinct toxicities caused by envenomation, neurotoxicity plays an important role in the paralysis of prey by s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b00bd1665bed78a0a36926162e7070e2
https://research.vu.nl/en/publications/d097d741-7419-4931-af63-fbdd15de032b
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