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Akademický článek

Enhancing quality of life in epilepsy with a digital intervention (emyna): Results of the ELAINE randomized controlled trial

Autor: Björn Meyer, Linda T. Betz, Katja Brückner, Martin Holtkamp

Publikováno v: Epilepsia Open, Vol 9, Iss 5, Pp 1758-1771 (2024)

Abstract Objective Despite the availability of pharmacological treatment for seizures, people with epilepsy (PwE) commonly experience impairments in quality of life (QoL). Given the limited access to psychosocial treatments for PwE, digital intervent

Externí odkaz: https://doaj.org/article/bae17b04773340d8845c48ab98e1adca

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Akademický článek

Effectiveness of a digital lifestyle management intervention (levidex) to improve quality of life in people with multiple sclerosis: results of a randomized controlled trial

Autor: Björn Meyer, Linda T. Betz, Gitta A. Jacob, Nicole Krause, Karin Riemann-Lorenz, Stefan M. Gold, Jana Pöttgen, Christoph Heesen

Publikováno v: BMC Neurology, Vol 24, Iss 1, Pp 1-12 (2024)

Abstract Background Multiple Sclerosis (MS) is a chronic inflammatory neurodegenerative disease with diverse symptomatology, significantly impacting patients’ quality of life (QoL). While pharmacological therapies focus primarily on reducing inflam

Externí odkaz: https://doaj.org/article/4a641efb9d0447adb1718b652e3781d4

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SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution

Autor: Maya Shemesh, Daniel Harari, Daniel C. Douek, Eyal Zoler, Yinon Rudich, Jeanne Chiaravalli, Orly Dym, Jiří Zahradník, Ira Marton, Hanne Leth Andersen, Chunlin Li, Robert A. Seder, Matthew Gagne, Mark G. Lewis, Bjorn Meyer, Gideon Schreiber, Nadav Elad, Shir Marciano

Publikováno v: Nature Microbiology
Nature Microbiology, Nature Publishing Group, 2021, ⟨10.1038/s41564-021-00954-4⟩
Nature Microbiology, 2021, ⟨10.1038/s41564-021-00954-4⟩

SARS-CoV-2 variants of interest and concern will continue to emerge for the duration of the COVID-19 pandemic. To map mutations in the receptor-binding domain (RBD) of the spike protein that affect binding to angiotensin-converting enzyme 2 (ACE2), t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::832d3f3b2cfa486cd2a9f41e44e53a76
https://hal-pasteur.archives-ouvertes.fr/pasteur-03321160

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SARS-CoV-2 RBD in vitro evolution follows contagious mutation spread, yet generates an able infection inhibitor

Autor: Maya Shemesh, Bjorn Meyer, Jiri Zahradnik, Shir Marciano, Nadav Elad, Yinon Rudich, Jeanne Chiaravalli, Orly Dym, Eyal Zoler, Gideon Schreiber

SARS-CoV-2 is continually evolving, with more contagious mutations spreading rapidly. Using in vitro evolution to affinity maturate the receptor-binding domain (RBD) of the spike protein towards ACE2 resulted in the more contagious mutations, S477N,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4e99fe7b6dd9a3a3443dc8972817b2f
https://doi.org/10.1101/2021.01.06.425392

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Akademický článek

Acceptability of a digital health application to empower persons with multiple sclerosis with moderate to severe disability: single-arm prospective pilot study

Autor: Max Kutzinski, Nicole Krause, Karin Riemann-Lorenz, Björn Meyer, Christoph Heesen

Publikováno v: BMC Neurology, Vol 23, Iss 1, Pp 1-13 (2023)

Abstract Background Many persons with multiple sclerosis (pwMS) desire to learn how health behaviour changes (e.g., dietary adjustments, physical activity, improvements in stress management) might help them manage their disease. Previous research has

Externí odkaz: https://doaj.org/article/bb768a9427a3459bb5169eaad7327bf5

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Akademický článek

Internet-delivered cognitive behavioural therapy programme to reduce depressive symptoms in patients with multiple sclerosis: a multicentre, randomised, controlled, phase 3 trial

Publikováno v: The Lancet: Digital Health, Vol 5, Iss 10, Pp e668-e678 (2023)

Summary: Background: Depression is three to four times more prevalent in patients with neurological and inflammatory disorders than in the general population. For example, in patients with multiple sclerosis, the 12-month prevalence of major depressi

Externí odkaz: https://doaj.org/article/c9fe12d3c3bf428fa2778f2b5bab9fcf

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Akademický článek

Effectiveness of an Internet-Based Self-Guided Program to Treat Depression in a Sample of Brazilian Users: Randomized Controlled Trial

Autor: Rodrigo T Lopes, Gustavo Chapetta da Rocha, Maria Adriana Svacina, Björn Meyer, Dajana Šipka, Thomas Berger

Publikováno v: JMIR Formative Research, Vol 7, p e46326 (2023)

BackgroundDepression is undertreated in Brazil. Deprexis is a self-guided internet-based program used to treat depressive symptoms based on empirically supported integrative and cognitive behavioral therapy. Evidence from a meta-analysis supports Dep

Externí odkaz: https://doaj.org/article/13e84236518c41469783e9fb5fa5f2be

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