Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Bjorn, Bakker"'
Autor:
Sebastijan Hobor, Maise Al Bakir, Crispin T. Hiley, Marcin Skrzypski, Alexander M. Frankell, Bjorn Bakker, Thomas B. K. Watkins, Aleksandra Markovets, Jonathan R. Dry, Andrew P. Brown, Jasper van der Aart, Hilda van den Bos, Diana Spierings, Dahmane Oukrif, Marco Novelli, Turja Chakrabarti, Adam H. Rabinowitz, Laila Ait Hassou, Saskia Litière, D. Lucas Kerr, Lisa Tan, Gavin Kelly, David A. Moore, Matthew J. Renshaw, Subramanian Venkatesan, William Hill, Ariana Huebner, Carlos Martínez-Ruiz, James R. M. Black, Wei Wu, Mihaela Angelova, Nicholas McGranahan, Julian Downward, Juliann Chmielecki, Carl Barrett, Kevin Litchfield, Su Kit Chew, Collin M. Blakely, Elza C. de Bruin, Floris Foijer, Karen H. Vousden, Trever G. Bivona, TRACERx consortium, Robert E. Hynds, Nnennaya Kanu, Simone Zaccaria, Eva Grönroos, Charles Swanton
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract The phenomenon of mixed/heterogenous treatment responses to cancer therapies within an individual patient presents a challenging clinical scenario. Furthermore, the molecular basis of mixed intra-patient tumor responses remains unclear. Here
Externí odkaz:
https://doaj.org/article/a58c4b29e1d8491b8078212067633916
Autor:
Nadeem Shaikh, Alice Mazzagatti, Simone De Angelis, Sarah C. Johnson, Bjorn Bakker, Diana C. J. Spierings, René Wardenaar, Eleni Maniati, Jun Wang, Michael A. Boemo, Floris Foijer, Sarah E. McClelland
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-24 (2022)
Abstract Background A major driver of cancer chromosomal instability is replication stress, the slowing or stalling of DNA replication. How replication stress and genomic instability are connected is not known. Aphidicolin-induced replication stress
Externí odkaz:
https://doaj.org/article/605dfc366d034220a1dfc1ef067430aa
Autor:
Louisa Nelson, Anthony Tighe, Anya Golder, Samantha Littler, Bjorn Bakker, Daniela Moralli, Syed Murtuza Baker, Ian J. Donaldson, Diana C. J. Spierings, René Wardenaar, Bethanie Neale, George J. Burghel, Brett Winter-Roach, Richard Edmondson, Andrew R. Clamp, Gordon C. Jayson, Sudha Desai, Catherine M. Green, Andy Hayes, Floris Foijer, Robert D. Morgan, Stephen S. Taylor
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
High-grade serous ovarian carcinoma is often associated with TP53 mutation and chromosomal instability (CIN). Here, the authors generate ex vivo cultures from biopsies and ascites of patients and perform characterization to evaluate CIN mechanisms an
Externí odkaz:
https://doaj.org/article/5f96b03935524c6e8d18bbc5878047b4
Autor:
Sarah de Jong, Anita de Breuk, Bjorn Bakker, Suresh Katti, Carel B. Hoyng, Sara C. Nilsson, Anna M. Blom, Lambert P. van den Heuvel, Anneke I. den Hollander, Elena B. Volokhina
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Complement factor I (FI) is a central inhibitor of the complement system, and impaired FI function increases complement activation, contributing to diseases such as age-related macular degeneration (AMD) and atypical hemolytic uremic syndrome (aHUS).
Externí odkaz:
https://doaj.org/article/134adb6a67974b3ea7d273245b6c434f
Autor:
Dorine C Hintzen, Mar Soto, Michael Schubert, Bjorn Bakker, Diana C J Spierings, Karoly Szuhai, Peter M Lansdorp, Roel J C Kluin, Floris Foijer, René H Medema, Jonne A Raaijmakers
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0268579 (2022)
Aneuploidy and chromosomal instability are both commonly found in cancer. Chromosomal instability leads to karyotype heterogeneity in tumors and is associated with therapy resistance, metastasis and poor prognosis. It has been hypothesized that aneup
Externí odkaz:
https://doaj.org/article/f584554feac24a5684cb7d0cfee58281
Autor:
Irena Bočkaj, Tosca E. I. Martini, Eduardo S. de Camargo Magalhães, Petra L. Bakker, Tiny G. J. Meeuwsen-de Boer, Inna Armandari, Saskia L. Meuleman, Marin T. Mondria, Colin Stok, Yannick P. Kok, Bjorn Bakker, René Wardenaar, Jonas Seiler, Mathilde J. C. Broekhuis, Hilda van den Bos, Diana C. J. Spierings, Femke C. A. Ringnalda, Hans Clevers, Ulrich Schüller, Marcel A. T. M. van Vugt, Floris Foijer, Sophia W. M. Bruggeman
Publikováno v:
PLoS Genetics, Vol 17, Iss 11 (2021)
While comprehensive molecular profiling of histone H3.3 mutant pediatric high-grade glioma has revealed extensive dysregulation of the chromatin landscape, the exact mechanisms driving tumor formation remain poorly understood. Since H3.3 mutant gliom
Externí odkaz:
https://doaj.org/article/f0f9f42a292e496a8dbe120dc4b20697
Autor:
Lin Zhou, Siqi Zheng, Fernando R Rosas Bringas, Bjorn Bakker, Judith E Simon, Petra L Bakker, Hinke G Kazemier, Michael Schubert, Maurits Roorda, Marcel A T M van Vugt, Michael Chang, Floris Foijer
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 12 (2021)
AbstractMaternal embryonic leucine zipper kinase (MELK) is frequently overexpressed in cancer, but the role of MELK in cancer is still poorly understood. MELK was shown to have roles in many cancer-associated processes including tumor growth, chemoth
Externí odkaz:
https://doaj.org/article/47ad807053204d65be2ed713aa553e49
Autor:
Pepijn M. Schoonen, Yannick P. Kok, Elles Wierenga, Bjorn Bakker, Floris Foijer, Diana C. J. Spierings, Marcel A. T. M. vanVugt
Publikováno v:
Molecular Oncology, Vol 13, Iss 11, Pp 2422-2440 (2019)
Poly(ADP‐ribose) polymerase (PARP) inhibitors are selectively cytotoxic in cancer cells with defects in homologous recombination (HR) (e.g., due to BRCA1/2 mutations). However, not all HR‐deficient tumors efficiently respond to PARP inhibition an
Externí odkaz:
https://doaj.org/article/6e02b44132fe453cb49c7cb621010ed2
Autor:
Joana Catarina Macedo, Sara Vaz, Bjorn Bakker, Rui Ribeiro, Petra Lammigje Bakker, Jose Miguel Escandell, Miguel Godinho Ferreira, René Medema, Floris Foijer, Elsa Logarinho
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Evidence for mitotic decline in aged cells and for aneuploidy-driven progression into full senescence is limited. Here, the authors find that in aged cells, mitotic gene repression leads to increased chromosome mis-segregation and aneuploidy that tri
Externí odkaz:
https://doaj.org/article/bfcab92a173641ca9b7e59b64b8285c9
Autor:
Joseph Thomas Worrall, Naoka Tamura, Alice Mazzagatti, Nadeem Shaikh, Tineke van Lingen, Bjorn Bakker, Diana Carolina Johanna Spierings, Elina Vladimirou, Floris Foijer, Sarah Elizabeth McClelland
Publikováno v:
Cell Reports, Vol 23, Iss 11, Pp 3366-3380 (2018)
Summary: A common assumption is that human chromosomes carry equal chances of mis-segregation during compromised cell division. Human chromosomes vary in multiple parameters that might generate bias, but technological limitations have precluded a com
Externí odkaz:
https://doaj.org/article/cb31babc6d1b43a99425021c716ed338