Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes (vol 50, pg 524, 2018)

Autor: Malik, R, Chauhan, G, Traylor, M, Sargurupremraj, M, Okada, Y, Mishra, A, Rutten-Jacobs, L, Giese, A-K, Van der Laan, SW, Gretarsdottir, S, Anderson, CD, Chong, M, Adams, HHH, Ago, T, Almgren, P, Amouyel, P, Ay, H, Bartz, TM, Benavente, OR, Bevan, S, Boncoraglio, GB, Brown, RD, Butterworth, AS, Carrera, C, Carty, CL, Chasman, DI, Chen, W-M, Cole, JW, Correa, A, Cotlarciuc, I, Cruchaga, C, Danesh, J, De Bakker, PIW, DeStefano, AL, Den Hoed, M, Duan, Q, Engelter, ST, Falcone, GJ, Gottesman, RF, Grewal, RP, Gudnason, V, Gustafsson, S, Haessler, J, Harris, TB, Hassan, A, Havulinna, AS, Heckbert, SR, Holliday, EG, Howard, G, Hsu, F-C, Hyacinth, IH, Ikram, MA, Ingelsson, E, Irvin, MR, Jian, X, Jimenez-Conde, J, Johnson, JA, Jukema, JW, Kanai, M, Keene, KL, Kissela, BM, Kleindorfer, DO, Kooperberg, C, Kubo, M, Lange, LA, Langefeld, CD, Langenberg, C, Launer, LJ, Lee, J-M, Lemmens, R, Leys, D, Lewis, CM, Lin, W-Y, Lindgren, AG, Lorentzen, E, Magnusson, PK, Maguire, J, Manichaikul, A, McArdle, PF, Meschia, JF, Mitchell, BD, Mosley, TH, Nalls, MA, Ninomiya, T, O'Donnell, MJ, Psaty, BM, Pulit, SL, Rannikmae, K, Reiner, AP, Rexrode, KM, Rice, K, Rich, SS, Ridker, PM, Rost, NS, Rothwell, PM, Rotter, JI, Rundek, T, Sacco, RL, Sakaue, S, Sale, MM, Salomaa, V, Sapkota, BR, Schmidt, R, Schmidt, CO, Schminke, U, Sharma, P, Slowik, A, Sudlow, CLM, Tanislav, C, Tatlisumak, T, Taylor, KD, Thijs, VNS, Thorleifsson, G, Thorsteinsdottir, U, Tiedt, S, Trompet, S, Tzourio, C, Van Duijn, CM, Walters, M, Wareham, NJ, Wassertheil-Smoller, S, Wilson, JG, Wiggins, KL, Yang, Q, Yusuf, S, Bis, JC, Pastinen, T, Ruusalepp, A, Schadt, EE, Koplev, S, Bjorkegren, JLM, Codoni, V, Civelek, M, Smith, NL, Tregouet, DA, Christophersen, IE, Roselli, C, Lubitz, SA, Ellinor, PT, Tai, ES, Kooner, JS, Kato, N, He, J, Van der Harst, P, Elliott, P, Chambers, JC, Takeuchi, F, Johnson, AD, Sanghera, DK, Melander, O, Jern, C, Strbian, D, Fernandez-Cadenas, I, Longstreth, WT, Rolfs, A, Hata, J, Woo, D, Rosand, J, Pare, G, Hopewell, JC, Saleheen, D, Stefansson, K, Worrall, BB, Kittner, SJ, Seshadri, S, Fornage, M, Markus, HS, Howson, JMM, Kamatani, Y, Debette, S, Dichgans, M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::baa55c97f47572e79f07ce720e55419e
http://hdl.handle.net/10044/1/72119

Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease.

Autor: Crawford AA; BHF Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Bankier S; BHF Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.; Division of Genetics and Genomics, The Roslin Institute, The University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK., Altmaier E; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Barnes CLK; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Clark DW; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Ermel R; Department of Cardiac Surgery, Tartu University Hospital, Tartu, Estonia., Friedrich N; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475, Greifswald, Germany.; German Center for Cardiovascular Disease (DZHK e.V.), partner site Greifswald, 17475, Greifswald, Germany., van der Harst P; Division of Heart and Lungs, Department of Cardiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, PO box 30.001, 9700 RB, The Netherlands., Joshi PK; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Karhunen V; Department of Epidemiology and Biostatistics, Medical Research Council-Public Health England Centre for Environment and Health, Imperial College London, London, UK.; Centre for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland., Lahti J; Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.; Turku Institute of Advanced Studies, University of Turku, Turku, Finland., Mahajan A; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Mangino M; Department of Twin Research and Genetic Epidemiology, King's College, Lambeth Palace Road, London, SE1 7EH, UK.; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK., Nethander M; Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Bioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Neumann A; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada., Pietzner M; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475, Greifswald, Germany.; German Center for Cardiovascular Disease (DZHK e.V.), partner site Greifswald, 17475, Greifswald, Germany., Sukhavasi K; Department of Cardiac Surgery, Tartu University Hospital, Tartu, Estonia., Wang CA; School of Medicine and Public Health, Faculty of Medicine and Health, University of Newcastle, Newcastle, NSW, 2308, Australia., Bakker SJL; Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Bjorkegren JLM; Integrated Cardio Metabolic Centre, Department of Medicine, Karolinska Institutet, Karolinska Universitetssjukhuset, Huddinge, Sweden.; Department of Genetics & Genomic Sciences, Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Clinical Gene Networks AB, Stockholm, Sweden., Campbell H; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Eriksson J; Folkhälsan Research Center, Helsinki, Finland.; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Helsinki, Singapore., Gieger C; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Hayward C; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital University of Edinburgh, Edinburgh, EH4 2XU, Scotland., Jarvelin MR; Department of Epidemiology and Biostatistics, Medical Research Council-Public Health England Centre for Environment and Health, Imperial College London, London, UK.; Centre for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.; Unit of Primary Health Care and Medical Research Center, Oulu University Hospital, Oulu, Finland., McLachlan S; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Morris AP; Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK.; Department of Biostatistics, University of Liverpool, Liverpool, UK.; Wellcome Centre for Human genetics, University of Oxford, Oxford, UK., Ohlsson C; Bioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Drug Treatment, Sahlgrenska University Hospital, Gothenburg, Sweden., Pennell CE; School of Medicine and Public Health, Faculty of Medicine and Health, University of Newcastle, Newcastle, NSW, 2308, Australia., Price J; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland., Rudan I; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Ruusalepp A; Department of Cardiac Surgery, Tartu University Hospital, Tartu, Estonia.; Clinical Gene Networks AB, Stockholm, Sweden., Spector T; NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK., Tiemeier H; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.; Department of Social and Behavioural Science, Harvard TH Chan School of Public Health, Boston, MA, USA., Völzke H; Institute for Community Medicine, University Medicine Greifswald, Walther-Rathenau-Str. 48, 17489, Greifswald, Germany., Wilson JF; Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital University of Edinburgh, Edinburgh, EH4 2XU, Scotland., Michoel T; Division of Genetics and Genomics, The Roslin Institute, The University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.; Computational Biology Unit, Department of Informatics, University of Bergen, PO Box 7803, 5020, Bergen, Norway., Timpson NJ; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Smith GD; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Walker BR; BHF Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK. Brian.Walker@ncl.ac.uk.; Clinical and Translational Research Institute, Newcastle University, Newcastle upon Tyne, UK. Brian.Walker@ncl.ac.uk.

Publikováno v: Journal of human genetics [J Hum Genet] 2021 Jun; Vol. 66 (6), pp. 625-636. Date of Electronic Publication: 2021 Jan 20.

Human Y Chromosome Exerts Pleiotropic Effects on Susceptibility to Atherosclerosis.

Autor: Eales JM; From the Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom (J.M.E., A.A.M., X.X., B.K., M.T.)., Maan AA; From the Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom (J.M.E., A.A.M., X.X., B.K., M.T.)., Xu X; From the Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom (J.M.E., A.A.M., X.X., B.K., M.T.)., Michoel T; The Roslin Institute, The University of Edinburgh, United Kingdom (T.M.).; Computational Biology Unit and Department of Informatics, University of Bergen, Norway (T.M.)., Hallast P; Institute of Biomedicine and Translational Medicine, University of Tartu, Estonia (P.H.)., Batini C; Department of Health Sciences (C.B., J.T.), University of Leicester, United Kingdom., Zadik D; Department of Genetics and Genome Biology (D.Z., M.A.J.), University of Leicester, United Kingdom., Prestes PR; School of Health and Life Sciences, Federation University Australia, Ballarat, Victoria (P.R.P., E.M., F.J.C.)., Molina E; School of Health and Life Sciences, Federation University Australia, Ballarat, Victoria (P.R.P., E.M., F.J.C.)., Denniff M; Department of Cardiovascular Sciences (M.D., N.J.S., F.J.C.), University of Leicester, United Kingdom., Schroeder J; Centre for Immunobiology, Institute of Infection, Immunity and Inflammation (J.S., P.M.), College of Medical, Veterinary and Life Sciences, University of Glasgow, United Kingdom.; Institute of Cardiovascular and Medical Sciences (J.S., P.M., T.J.G.), College of Medical, Veterinary and Life Sciences, University of Glasgow, United Kingdom., Bjorkegren JLM; Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY (J.L.M.B.)., Thompson J; Department of Health Sciences (C.B., J.T.), University of Leicester, United Kingdom., Maffia P; Centre for Immunobiology, Institute of Infection, Immunity and Inflammation (J.S., P.M.), College of Medical, Veterinary and Life Sciences, University of Glasgow, United Kingdom.; Institute of Cardiovascular and Medical Sciences (J.S., P.M., T.J.G.), College of Medical, Veterinary and Life Sciences, University of Glasgow, United Kingdom.; Department of Pharmacy, University of Naples Federico II, Italy (P.M.)., Guzik TJ; Institute of Cardiovascular and Medical Sciences (J.S., P.M., T.J.G.), College of Medical, Veterinary and Life Sciences, University of Glasgow, United Kingdom.; Jagiellonian University College of Medicine, Kraków, Poland (T.J.G.)., Keavney B; From the Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom (J.M.E., A.A.M., X.X., B.K., M.T.).; Division of Medicine, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, United Kingdom (B.K., M.T.)., Jobling MA; Department of Genetics and Genome Biology (D.Z., M.A.J.), University of Leicester, United Kingdom., Samani NJ; Department of Cardiovascular Sciences (M.D., N.J.S., F.J.C.), University of Leicester, United Kingdom.; NIHR Leicester Biomedical Research Centre, United Kingdom (N.J.S.)., Charchar FJ; Department of Cardiovascular Sciences (M.D., N.J.S., F.J.C.), University of Leicester, United Kingdom.; School of Health and Life Sciences, Federation University Australia, Ballarat, Victoria (P.R.P., E.M., F.J.C.).; Department of Physiology, University of Melbourne, Parkville, Victoria, Australia (F.J.C.)., Tomaszewski M; From the Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom (J.M.E., A.A.M., X.X., B.K., M.T.).; Division of Medicine, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, United Kingdom (B.K., M.T.).

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2019 Nov; Vol. 39 (11), pp. 2386-2401. Date of Electronic Publication: 2019 Sep 05.

EnsembleCNV: an ensemble machine learning algorithm to identify and genotype copy number variation using SNP array data.

Autor: Zhang Z; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Cheng H; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Hong X; Center on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA., Di Narzo AF; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Franzen O; Integrated Cardio Metabolic Centre, Department of Medicine, Karolinska Institutet, Karolinska Universitetssjukhuset, Huddinge, Sweden., Peng S; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Ruusalepp A; Department of Cardiac Surgery, Tartu University Hospital, Tartu, Estonia., Kovacic JC; Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA., Bjorkegren JLM; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Integrated Cardio Metabolic Centre, Department of Medicine, Karolinska Institutet, Karolinska Universitetssjukhuset, Huddinge, Sweden., Wang X; Center on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.; Division of General Pediatrics & Adolescent Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Hao K; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.; The Tenth People's Hospital, Tongji University, Shanghai 200072, China.; College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2019 Apr 23; Vol. 47 (7), pp. e39.