Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

Autor: Sade-Feldman, Moshe, Yizhak, Keren, Bjorgaard, Stacey L., Ray, John P., de Boer, Carl G., Jenkins, Russell W., Lieb, David J., Chen, Jonathan H., Frederick, Dennie T., Barzily-Rokni, Michal, Freeman, Samuel S., Reuben, Alexandre, Hoover, Paul J., Villani, Alexandra-Chloé, Ivanova, Elena, Portell, Andrew, Lizotte, Patrick H., Aref, Amir R., Eliane, Jean-Pierre, Hammond, Marc R., Vitzthum, Hans, Blackmon, Shauna M., Li, Bo, Gopalakrishnan, Vancheswaran, Reddy, Sangeetha M., Cooper, Zachary A., Paweletz, Cloud P., Barbie, David A., Stemmer-Rachamimov, Anat, Flaherty, Keith T., Wargo, Jennifer A., Boland, Genevieve M., Sullivan, Ryan J., Getz, Gad, Hacohen, Nir

Publikováno v: In Cell 1 November 2018 175(4):998-1013

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PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hicells and anti-PD-1 resistance

Autor: Verma, Vivek, Shrimali, Rajeev K, Ahmad, Shamim, Dai, Winjie, Wang, Hua, Lu, Sumin, Nandre, Rahul, Gaur, Pankaj, Lopez, Jose, Sade-Feldman, Moshe, Yizhak, Keren, Bjorgaard, Stacey L., Flaherty, Keith T., Wargo, Jennifer A., Boland, Genevieve M., Sullivan, Ryan J., Getz, Gad, Hammond, Scott A., Tan, Ming, Qi, Jingjing, Wong, Phillip, Merghoub, Taha, Wolchok, Jedd, Hacohen, Nir, Janik, John E., Mkrtichyan, Mikayel, Gupta, Seema, Khleif, Samir N.

Publikováno v: Nature Immunology; September 2019, Vol. 20 Issue: 9 p1231-1243, 13p

Author Correction: PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1 ⁺ CD38 ^hi cells and anti-PD-1 resistance.

Autor: Verma V; Georgia Cancer Center, Augusta University, Augusta, GA, USA.; The Loop Immuno-Oncology Laboratory, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Shrimali RK; Georgia Cancer Center, Augusta University, Augusta, GA, USA.; Therapeutic Discovery, MD Anderson Cancer Center, Houston, TX, USA., Ahmad S; Georgia Cancer Center, Augusta University, Augusta, GA, USA.; Five Prime Therapeutics Inc., South San Francisco, CA, USA., Dai W; Georgia Cancer Center, Augusta University, Augusta, GA, USA., Wang H; Georgia Cancer Center, Augusta University, Augusta, GA, USA., Lu S; Georgia Cancer Center, Augusta University, Augusta, GA, USA., Nandre R; Georgia Cancer Center, Augusta University, Augusta, GA, USA.; The Loop Immuno-Oncology Laboratory, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Gaur P; Georgia Cancer Center, Augusta University, Augusta, GA, USA.; The Loop Immuno-Oncology Laboratory, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Lopez J; The Loop Immuno-Oncology Laboratory, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Sade-Feldman M; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Yizhak K; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Bjorgaard SL; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Flaherty KT; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA, USA., Wargo JA; Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Boland GM; Department of Surgery, Massachusetts General Hospital, Boston, MA, USA., Sullivan RJ; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA, USA., Getz G; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Hammond SA; MedImmune LLC, Gaithersburg, MD, USA., Tan M; Department of Biostatistics, Bioinformatics & Biomathematics, Georgetown University, Washington, DC, USA., Qi J; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Wong P; Memorial Sloan Kettering Cancer Center, New York, NY, USA., Merghoub T; Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Weill Cornell Medical and Graduate Schools, New York, NY, USA., Wolchok J; Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Weill Cornell Medical and Graduate Schools, New York, NY, USA., Hacohen N; Department of Medicine, Massachusetts General Hospital Cancer Center, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Janik JE; Georgia Cancer Center, Augusta University, Augusta, GA, USA.; Incyte Inc., Wilmington, DE, USA., Mkrtichyan M; Georgia Cancer Center, Augusta University, Augusta, GA, USA.; The Loop Immuno-Oncology Laboratory, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.; A2 Biotherapeutics, Agoura Hills, CA, USA., Gupta S; Georgia Cancer Center, Augusta University, Augusta, GA, USA.; The Loop Immuno-Oncology Laboratory, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA., Khleif SN; Georgia Cancer Center, Augusta University, Augusta, GA, USA. snk48@georgetown.edu.; The Loop Immuno-Oncology Laboratory, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA. snk48@georgetown.edu.

Publikováno v: Nature immunology [Nat Immunol] 2019 Nov; Vol. 20 (11), pp. 1555.