Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Bjorg Gudmundsdottir"'
Autor:
Naoya Uchida, Claire M. Drysdale, Tina Nassehi, Jackson Gamer, Morgan Yapundich, Julia DiNicola, Yoshitaka Shibata, Malikiya Hinds, Bjorg Gudmundsdottir, Juan J. Haro-Mora, Selami Demirci, John F. Tisdale
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 121-132 (2021)
Gene editing with the CRISPR-Cas9 system could revolutionize hematopoietic stem cell (HSC)-targeted gene therapy for hereditary diseases, including sickle cell disease (SCD). Conventional delivery of editing tools by electroporation limits HSC fitnes
Externí odkaz:
https://doaj.org/article/367c1878f8f8434c82d116b980d84a7a
Autor:
Reut Suliman-Lavie, Ben Title, Yahel Cohen, Nanako Hamada, Maayan Tal, Nitzan Tal, Galya Monderer-Rothkoff, Bjorg Gudmundsdottir, Kristbjorn O. Gudmundsson, Jonathan R. Keller, Guo-Jen Huang, Koh-ichi Nagata, Yosef Yarom, Sagiv Shifman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
POGZ is an autism spectrum disorder risk gene. How POGZ mutations result in ASD is unclear and animal models are lacking. Here, the authors generate a brain specific Pogz deficient mouse presenting ASD-like behaviour and show the effects of Pogz defi
Externí odkaz:
https://doaj.org/article/14ea55860cc94204933e8e502705deac
Autor:
Selami Demirci, Bjorg Gudmundsdottir, Quan Li, Juan J. Haro-Mora, Tina Nassehi, Claire Drysdale, Morgan Yapundich, Jackson Gamer, Fayaz Seifuddin, John F. Tisdale, Naoya Uchida
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 912-921 (2020)
Lentiviral addition of βT87Q-globin, a modified β-globin with an anti-sickling mutation, is currently being used in gene therapy trials for sickle cell disease (SCD) and β-thalassemia patients. βT87Q-globin interferes with sickle hemoglobin (HbS)
Externí odkaz:
https://doaj.org/article/b8f50309fcfd40f7925c9851843d83cf
Autor:
Bjorg Gudmundsdottir, Kristbjorn O. Gudmundsson, Kimberly D. Klarmann, Satyendra K. Singh, Lei Sun, Shweta Singh, Yang Du, Vincenzo Coppola, Luke Stockwin, Nhu Nguyen, Lino Tessarollo, Leifur Thorsteinsson, Olafur E. Sigurjonsson, Sveinn Gudmundsson, Thorunn Rafnar, John F. Tisdale, Jonathan R. Keller
Publikováno v:
Cell Reports, Vol 23, Iss 11, Pp 3236-3248 (2018)
Summary: Fetal globin genes are transcriptionally silenced during embryogenesis through hemoglobin switching. Strategies to derepress fetal globin expression in the adult could alleviate symptoms in sickle cell disease and β-thalassemia. We identifi
Externí odkaz:
https://doaj.org/article/e0d1e32368d04fa6970dd5594931da2a
Autor:
Reut Suliman-Lavie, Ben Title, Yahel Cohen, Nanako Hamada, Maayan Tal, Nitzan Tal, Galya Monderer-Rothkoff, Bjorg Gudmundsdottir, Kristbjorn O. Gudmundsson, Jonathan R. Keller, Guo-Jen Huang, Koh-ichi Nagata, Yosef Yarom, Sagiv Shifman
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/86f6f8a5fa734315aa46b75ea5b936d2
Autor:
Johanna, Torfadottir, Sigrun Eva, Einarsdottir, Asgeir R, Helgason, Birna, Thorisdottir, Rebekka Bjorg, Gudmundsdottir, Anna Bara, Unnarsdottir, Laufey, Tryggvadottir, Helgi, Birgisson, Gudfinna Halla, Thorvaldsdottir
Publikováno v:
Læknablaðið. 108:447-454
INTRODUCTION: In the coming years, an increase in the number of cancer cases can be expected in Iceland. It is important to gain more insight into the experiences of the diagnostic- and treatment phase among those diagnosed with cancer to improve qua
Autor:
Juan J. Haro-Mora, Claire M. Drysdale, Malikiya Hinds, Julia DiNicola, Morgan Yapundich, Jackson Gamer, Yoshitaka Shibata, Selami Demirci, Bjorg Gudmundsdottir, John F. Tisdale, Naoya Uchida, Tina Nassehi
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss, Pp 121-132 (2021)
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss, Pp 121-132 (2021)
Gene editing with the CRISPR-Cas9 system could revolutionize hematopoietic stem cell (HSC)-targeted gene therapy for hereditary diseases, including sickle cell disease (SCD). Conventional delivery of editing tools by electroporation limits HSC fitnes
Autor:
Jackson Gamer, Juan J. Haro-Mora, Fayaz Seifuddin, John F. Tisdale, Selami Demirci, Claire M. Drysdale, Quan Li, Tina Nassehi, Naoya Uchida, Bjorg Gudmundsdottir, Morgan Yapundich
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss, Pp 912-921 (2020)
Lentiviral addition of βT87Q-globin, a modified β-globin with an anti-sickling mutation, is currently being used in gene therapy trials for sickle cell disease (SCD) and β-thalassemia patients. βT87Q-globin interferes with sickle hemoglobin (HbS)
Autor:
Bjorg Gudmundsdottir, Kristbjorn O. Gudmundsson, Maayan Tal, Nanako Hamada, Guo-Jen Huang, Nitzan Tal, Yosef Yarom, Galya Monderer-Rothkoff, Ben Title, Sagiv Shifman, Jonathan R. Keller, Koh-ichi Nagata, Yahel Cohen, Reut Suliman-Lavie
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Several genes implicated in autism spectrum disorder (ASD) are chromatin regulators, including POGZ. The cellular and molecular mechanisms leading to ASD impaired social and cognitive behavior are unclear. Animal models are crucial for studying the e
Autor:
Shweta Singh, Thorunn Rafnar, Bjorg Gudmundsdottir, Kimberly D. Klarmann, Yang Du, Lei Sun, Vincenzo Coppola, Jonathan R. Keller, Leifur Thorsteinsson, Nhu Nguyen, John F. Tisdale, Lino Tessarollo, Luke H. Stockwin, Kristbjorn O. Gudmundsson, Sveinn Vidar Gudmundsson, Olafur E. Sigurjonsson, Satyendra K. Singh
Publikováno v:
Cell Reports, Vol 23, Iss 11, Pp 3236-3248 (2018)
Cell reports
Cell reports
SUMMARY Fetal globin genes are transcriptionally silenced during embryogenesis through hemoglobin switching. Strategies to derepress fetal globin expression in the adult could alleviate symptoms in sickle cell disease and β-thalassemia. We identifie