Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Bjoern Wagner"'
Autor:
Cornelia Hensel, Lars Grenacher, Céline D. Alt, Simone Gantz, Hans Jürgen Gerner, Cornelia Putz, Bjoern Wagner, Norbert Weidner
Publikováno v:
Spinal Cord. 58:203-210
A prospective single arm study. Previously we have demonstrated that magnetic resonance (MR) defecography is feasible in participants with complete spinal cord injury (SCI). The main aim of this study is to evaluate whether MR defecography can provid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac8cdc0dfe9055383c749f97179eb09
https://doi.org/10.1038/s41393-019-0351-8
https://doi.org/10.1038/s41393-019-0351-8
Autor:
Hua Yang, Milena Čolović, Helen Merkens, Bjoern Wagner, Paul Schaffer, Francois Benard, Noeen Malik, Robert Britton, Rainer E. Martin, Matthew B. Nodwell
Publikováno v:
Journal of Nuclear Medicine. 60:1003-1009
1003 Introduction: Target specificity is one of the main goals when developing new specific agents for oncological diagnosis and therapy. Animal experiments with xenografts mostly in mice are usually performed to obtain information about target speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c6745a2003d91e7a732ab45c52f280d
https://doi.org/10.2967/jnumed.118.220483
https://doi.org/10.2967/jnumed.118.220483
Autor:
Neil, Parrott, Cordula, Stillhart, Marc, Lindenberg, Bjoern, Wagner, Karey, Kowalski, Elena, Guerini, Nassim, Djebli, Georgina, Meneses-Lorente
Publikováno v:
The AAPS Journal. 22
Entrectinib is a potent and selective tyrosine kinase inhibitor (TKI) of TRKA/B/C, ROS1, and ALK with both systemic and CNS activities, which has recently received FDA approval for ROS1 fusion-positive non-small cell lung cancer and NTRK fusion-posit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd42f39c2deca8f6a7b824318d4a45c
https://doi.org/10.1208/s12248-020-00463-y
https://doi.org/10.1208/s12248-020-00463-y
Autor:
Sara Belli, Rubén Alvarez-Sánchez, Holger Fischer, Frauke Assmus, Franz Schuler, Bjoern Wagner, Michael Honer
Publikováno v:
Molecular Pharmaceutics. 12:4529-4541
The unbound drug concentration-effect relationship in brain is a key aspect in CNS drug discovery and development. In this work, we describe an in vitro high-throughput distribution assay between an aqueous buffer and a microemulsion of porcine brain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6340d05f79540179f78b60ded279b01b
https://doi.org/10.1021/acs.molpharmaceut.5b00717
https://doi.org/10.1021/acs.molpharmaceut.5b00717
In vitro safety assessment in early drug discovery represents an important step to detect potential safety-related liabilities. It reduces late stage attrition and allows candidate optimization. In this study, we report on the use of the LogDBPL assa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a3a36dac676bf240b7f1b7fa63f851
http://hdl.handle.net/11391/1402140
http://hdl.handle.net/11391/1402140
Autor:
Brian Cutting, Beat Ernst, Martin Smieško, Matthias Wittwer, Bjoern Wagner, Jacqueline Bezençon, Manfred Kansy
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 93:147-155
pKa values of acids and protonated bases have an essential impact on organic synthesis, medicinal chemistry, and material and food sciences. In drug discovery and development, they are of utmost importance for the prediction of pharmacokinetic and ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39705d88cf0c776cd5a42a5362c28f98
https://doi.org/10.1016/j.jpba.2013.12.014
https://doi.org/10.1016/j.jpba.2013.12.014
Autor:
Xinlai Cheng, Therese Scholz, Gert Fricker, Manfred Kansy, Bjoern Wagner, Nasim Heshmati, Gerhard Eisenbrand
Publikováno v:
European Journal of Pharmaceutical Sciences. 50:467-475
The active component of the traditional Chinese medicine, indirubin, exerts anticancer effect on different cancer cell lines. E804, a potent derivative of indirubin inhibits the activation of Stat3 and Stat5 in chronic myelocytic leukaemia (CML) cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc1ccfcd672bb9cc056091276f7846a
https://doi.org/10.1016/j.ejps.2013.08.021
https://doi.org/10.1016/j.ejps.2013.08.021
Autor:
Laura Goracci, Francesca Milletti, Loriano Storchi, Manfred Kansy, Bjoern Wagner, Gabriele Cruciani, Stefanie Bendels
Publikováno v:
European Journal of Medicinal Chemistry. 45:4270-4279
We have recently developed a tool, MoKa, to predict the pK(a) of organic compounds using a large dataset of over 26,500 literature pK(a) values as a training set. However, predicting accurately pK(a) (0.5 pH units) remains challenging for novel serie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336a0de083aebbff2fb3b943ac29b984
https://doi.org/10.1016/j.ejmech.2010.06.026
https://doi.org/10.1016/j.ejmech.2010.06.026
Autor:
Marine Guillot-Nieckowski, Harry Heinzelmann, Manfred Kansy, Derk Joester, Meike Stöhr, Raphaël Pugin, Marc Adrian, Bjoern Wagner, Myriam Losson, François Diederich, Jean Louis Gallani
Publikováno v:
Langmuir
Langmuir, American Chemical Society, 2007, 23, pp.737-746
Langmuir, 23(2), 737-746. AMER CHEMICAL SOC
Langmuir, American Chemical Society, 2007, 23, pp.737-746
Langmuir, 23(2), 737-746. AMER CHEMICAL SOC
Cationic lipids and polymers are routinely used for cell transfection, and a variety of structure-activity relation data have been collected. Few studies, however, focus on the structural aspects of self-assembly as a crucial control parameter for ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab8316aa8f73323ffe7165662ab83712
https://doi.org/10.1021/la0624891
https://doi.org/10.1021/la0624891
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 68
Here we present a miniaturized assay, referred to as Carrier-Mediated Distribution System (CAMDIS) for fast and reliable measurement of octanol/water distribution coefficients, log D(oct). By introducing a filter support for octanol, phase separation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2557589e6834add53a1e61f6f87ef9e9
https://pubmed.ncbi.nlm.nih.gov/25513709
https://pubmed.ncbi.nlm.nih.gov/25513709