Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Bjoern Bauer"'
Autor:
Geetika Nehra, Sasivimon Promsan, Ruedeemars Yubolphan, Wijitra Chumboatong, Pornpun Vivithanaporn, Bryan J. Maloney, Anusorn Lungkaphin, Bjoern Bauer, Anika M. S. Hartz
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-22 (2024)
Abstract Background Patients with Alzheimer's disease (AD) develop blood–brain barrier dysfunction to varying degrees. How aging impacts Aβ pathology, blood–brain barrier function, and cognitive decline in AD remains largely unknown. In this stu
Externí odkaz:
https://doaj.org/article/b356e3c9c2a2479891a940c110867957
Autor:
Brianna M. Holder, Shaina E. Tolan, Kaleb K. Heinrich, Kaitlin C. Miller, Natalie Hudson, Geetika Nehra, Michelle E. Pizzo, Steffen E. Storck, William F. Elmquist, Britta Engelhardt, Irena Loryan, Michal Toborek, Bjoern Bauer, Anika M. S. Hartz, Brandon J. Kim
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-11 (2022)
Abstract Background Scientific conferences are vital communication events for scientists in academia, industry, and government agencies. In the brain barriers research field, several international conferences exist that allow researchers to present d
Externí odkaz:
https://doaj.org/article/9b52a93633bb43e6822fea744263dc65
Publikováno v:
Journal of Clinical and Translational Science, Vol 6, Pp 87-87 (2022)
OBJECTIVES/GOALS: We have shown that glioblastoma upregulates blood-brain barrier drug efflux transporters via a mechanism that likely involves TNFα and PI3K/Akt. Our goal is to repurpose FDA-approved PI3K/Akt inhibitors to increase anticancer dru
Externí odkaz:
https://doaj.org/article/368f87376b5441f28ae2b84ffd14fd22
Autor:
Jennifer Lee, Lucille M. Yanckello, David Ma, Jared D. Hoffman, Ishita Parikh, Scott Thalman, Bjoern Bauer, Anika M. S. Hartz, Fahmeed Hyder, Ai-Ling Lin
Publikováno v:
Frontiers in Aging Neuroscience, Vol 10 (2018)
The mechanistic target of rapamycin (mTOR) is a nutrient sensor of eukaryotic cells. Inhibition of mechanistic mTOR signaling can increase life and health span in various species via interventions that include rapamycin and caloric restriction (CR).
Externí odkaz:
https://doaj.org/article/8a74dc9b9c6340bfb5d737225ecefe53
Autor:
Jared D. Hoffman, Ishita Parikh, Stefan J. Green, George Chlipala, Robert P. Mohney, Mignon Keaton, Bjoern Bauer, Anika M. S. Hartz, Ai-Ling Lin
Publikováno v:
Frontiers in Aging Neuroscience, Vol 9 (2017)
Advancing age is the top risk factor for the development of neurodegenerative disorders, including Alzheimer’s disease (AD). However, the contribution of aging processes to AD etiology remains unclear. Emerging evidence shows that reduced brain met
Externí odkaz:
https://doaj.org/article/bb227085d55c400fbb159dda0c3c7eff
Autor:
Surabhi Talele, Afroz S. Mohammad, Julia A. Schulz, Bjoern Bauer, Anika M. S. Hartz, Jann N. Sarkaria, William F. Elmquist
Publikováno v:
Drug Delivery to the Brain ISBN: 9783030887728
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8b33c14ff890e07799f5ee586654751
https://doi.org/10.1007/978-3-030-88773-5_24
https://doi.org/10.1007/978-3-030-88773-5_24
Publikováno v:
Pharmacol Ther
Alzheimer’s disease (AD) is the most common form of dementia. AD brain pathology starts decades before the onset of clinical symptoms. One early pathological hallmark is blood-brain barrier dysfunction characterized by barrier leakage and associate
Publikováno v:
SSRN Electronic Journal.
Autor:
Anton Pekcec, Anika M.S. Hartz, Yu Zhong, Bjoern Bauer, Juli Schlichtiger, Emma L. B. Soldner
Publikováno v:
Molecular Pharmaceutics. 14:999-1011
A cure for epilepsy is currently not available, and seizure genesis, seizure recurrence, and resistance to antiseizure drugs remain serious clinical problems. Studies show that the blood-brain barrier is altered in animal models of epilepsy and in ep
Autor:
Bjoern Bauer, Anika M.S. Hartz, Anton Pekcec, Richard J. Kryscio, Juli Schlichtiger, Emma L. B. Soldner, Ralf G. Rempe
Publikováno v:
FASEB J
Blood–brain barrier dysfunction in epilepsy contributes to seizures and resistance to antiseizure drugs. Reports show that seizures increase brain glutamate levels, leading to barrier dysfunction. One component of barrier dysfunction is overexpress