Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Bjoern, Schwer"'
Autor:
Christin Schmidt, Sarah Cohen, Brian L. Gudenas, Sarah Husain, Annika Carlson, Samantha Westelman, Linyu Wang, Joanna J. Phillips, Paul A. Northcott, William A. Weiss, Bjoern Schwer
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract SNCAIP duplication may promote Group 4 medulloblastoma via induction of PRDM6, a poorly characterized member of the PRDF1 and RIZ1 homology domain-containing (PRDM) family of transcription factors. Here, we investigated the function of PRDM6
Externí odkaz:
https://doaj.org/article/f24a13935b9e45c388a2ca2c8a1ffbb3
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Recent studies revealed classes of recurrent DNA double-strand breaks (DSBs) in neural stem/progenitor cells, including transcription-associated, promoter-proximal breaks and recurrent DSB clusters in late-replicating, long neural genes that
Externí odkaz:
https://doaj.org/article/e95152eb596743f982dfc46e00a7d276
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Externí odkaz:
https://doaj.org/article/dfc92a72b0e84b5eb72a2e299ffe4625
Autor:
Pavlina Chuntova, Kira Downey, Ryusuke Hatae, Tiffany A Chen, Abigail L Mende, Megan Montoya, Bjoern Schwer, Jayne Skinner, Hideho Okada, Gary Kohanbash, Takahide Nejo, Yitzhar E. Goretsky, Yafei Hou, Hong-Erh Liang, David Diebold, Akane Yamamichi, Ryosuke Naka
Publikováno v:
Neuro-oncology, vol 24, iss 2
Neuro Oncol
Neuro Oncol
Background Rigorous preclinical studies of chimeric antigen receptor (CAR) immunotherapy will require large quantities of consistent and high-quality CAR-transduced T (CART) cells that can be used in syngeneic mouse glioblastoma (GBM) models. To this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e413a9fb76c4ae0a30fdd3ad9738da0b
https://doi.org/10.1093/neuonc/noab182
https://doi.org/10.1093/neuonc/noab182
Autor:
Christin Schmidt, Sarah Husain, Annika Carlson, Sarah Cohen, Samantha Westelman, Linyu Wang, William Weiss, Bjoern Schwer
Publikováno v:
Neuro-Oncology. 24:vii297-vii298
Group 4 medulloblastoma (MB) is the most common medulloblastoma subgroup and shows high incidence of metastasis and late-onset relapse. Group 4 MBs lack a unifying oncogenic driver and treatment targets, despite extensive genomic characterization. Gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::700d89578586e15222f7e6b3631dbaac
https://doi.org/10.1093/neuonc/noac209.1159
https://doi.org/10.1093/neuonc/noac209.1159
Autor:
Leah C, Dorman, Phi T, Nguyen, Caroline C, Escoubas, Ilia D, Vainchtein, Yinghong, Xiao, Peter V, Lidsky, Haruna, Nakajo, Nicholas J, Silva, Christian, Lagares-Linares, Ellen Y, Wang, Sunrae E, Taloma, Beatriz, Cuevas, Hiromi, Nakao-Inoue, Brianna M, Rivera, Bjoern, Schwer, Carlo, Condello, Raul, Andino, Tomasz J, Nowakowski, Anna V, Molofsky
Publikováno v:
bioRxiv : the preprint server for biology.
Microglia, the innate immune cells of the brain, are exquisitely sensitive to dynamic changes in the neural environment. Using single cell RNA sequencing of the postnatal somatosensory cortex during topographic remapping, we identified a type I inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::77fff49b25e7b36499cbc1dc125ab87a
https://pubmed.ncbi.nlm.nih.gov/35233577
https://pubmed.ncbi.nlm.nih.gov/35233577
Autor:
Zhuoyi Liang, Beatriz Alvarado, Bjoern Schwer, Amelia N. Chang, Alex A. Pollen, Aimee M. Chapdelaine-Williams, Frederick W. Alt, Hai-Qiang Dai
Publikováno v:
Nat Protoc
Nature protocols, vol 15, iss 10
Nature protocols, vol 15, iss 10
We provide a protocol for generating forebrain structures in vivo from mouse embryonic stem cells (ESCs) via neural blastocyst complementation (NBC). We developed this protocol for studies of development and function of specific forebrain regions, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09c40d545c67bfe0f543f0b62aaa78c3
https://doi.org/10.1038/s41596-020-0364-y
https://doi.org/10.1038/s41596-020-0364-y
Recent work has revealed classes of recurrent DNA double-strand breaks (DSBs) in neural stem/progenitor cells, including transcription-associated, promoter-proximal breaks and recurrent DSB clusters in late-replicating, long neural genes. However, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bf9146ee7f3e63bb3233987a6651004
https://doi.org/10.1101/2021.09.20.460546
https://doi.org/10.1101/2021.09.20.460546
Autor:
Caroline C. Escoubas, Leah C. Dorman, Phi T. Nguyen, Christian Lagares-Linares, Haruna Nakajo, Sarah R. Anderson, Beatriz Cuevas, Ilia D. Vainchtein, Nicholas J. Silva, Yinghong Xiao, Peter V. Lidsky, Ellen Y. Wang, Sunrae E. Taloma, Hiromi Nakao-Inoue, Bjoern Schwer, Raul Andino, Tomasz J. Nowakowski, Anna V. Molofsky
SummaryMicroglia are brain resident phagocytes that can engulf synaptic components and extracellular matrix as well as whole neurons. However, whether there are unique molecular mechanisms that regulate these distinct phagocytic states is unknown. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32d4dfab35cc3d1bbd40ad782fcefd82
https://doi.org/10.1101/2021.04.29.441889
https://doi.org/10.1101/2021.04.29.441889
Autor:
Tiffany A Chen, David Diebold, Yitzhar E. Goretsky, Hideho Okada, Bjoern Schwer, Yafei Hou, Jayne Skinner, Hong-Erh Liang, Abigail L Mende, Ryosuke Naka, Pavlina Chuntova, Kira Downey, Megan Montoya, Gary Kohanbash, Takahide Nejo, Akane Yamamichi
BackgroundRigorous preclinical studies of chimeric antigen receptor (CAR) immunotherapy will require large quantities of consistent and high-quality CAR-transduced T (CART)-cells that can be used in syngeneic mouse glioblastoma (GBM) models. To this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b86bcff4afeb945f4ecee99fa7142dc
https://doi.org/10.1101/2021.01.31.429020
https://doi.org/10.1101/2021.01.31.429020