Lipoprotein lipase activity is decreased in a large cohort of patients with coronary artery disease and is associated with changes in lipids and lipoproteins

Autor: Howard E. Henderson, John J.P. Kastelein, Aeilko H. Zwinderman, Eric Gagné, J. Wouter Jukema, Paul W.A. Reymer, Björn E. Groenemeyer, Kong I. Lie, Albert V.G. Bruschke, Michael R. Hayden, Hans Jansen

Publikováno v: Journal of Lipid Research, Vol 40, Iss 4, Pp 735-743 (1999)

Lipoprotein lipase (LPL) is crucial in the hydrolysis of triglycerides (TG) in TG-rich lipoproteins in the formation of HDL particles. As both these lipoproteins play an important role in the pathogenesis of atherosclerotic vascular disease, we sough

Externí odkaz: https://doaj.org/article/c031192f61904d1ca0cd5bb14f34edba

Patients With ApoE3 Deficiency (E2/2, E3/2, and E4/2) Who Manifest With Hyperlipidemia Have Increased Frequency of an Asn 291→Ser Mutation in the Human LPL Gene

Autor: Hanfang Zhang, John D. Brunzell, Yuanhong Ma, Jiri Frohlich, P.W.A. Reymer, Ian J. Forsythe, Ming Sun Liu, John J.P. Kastelein, Björn E. Groenemeyer, Michael R. Hayden

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology, 15(10), 1695-1703. Lippincott Williams and Wilkins

Abstract Approximately 1% to 2% of persons in the general population are homozygous for a lipoprotein receptor–binding defective form of apoE (apoE2/2). However, only a small percentage (2% to 5%) of all apoE2/2 homozygotes develop type III hyperli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b11d03ae20586c7b65ca3cc4d68fd274
https://doi.org/10.1161/01.atv.15.10.1695

Ser447stop mutation in lipoprotein lipase is associated with elevated HDL cholesterol levels in normolipidemic males

Autor: Jolanda M. A. Boer, Jan Albert Kuivenhoven, John J.P. Kastelein, Björn E. Groenemeyer, T. Bruin, P.W.A. Reymer, Hans Jansen, Riteke Berghuis, Jacob C. Seidell

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology, 17(3), 595-9. Lippincott Williams and Wilkins
Arteriosclerosis, thrombosis and vascular biology, 17, 595-599. Lippincott Williams & Wilkins
Kuivenhoven, J A, Groenemeyer, B E, Boer, J M, Reymer, P W A, Berghuis, R, Bruin, T, Jansen, H, Seidell, J C & Kastelein, J J 1997, ' Ser447stop mutation in lipoprotein lipase is associated with elevated HDL cholesterol levels in normolipidemic males ', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 17, no. 3, pp. 595-9 .
Arteriosclerosis Thrombosis and Vascular Biology, 17, 595-599
Vrije Universiteit Amsterdam
Arteriosclerosis, thrombosis, and vascular biology, 17(3), 595-599. Lippincott Williams and Wilkins
Arteriosclerosis Thrombosis and Vascular Biology 17 (1997)
Arteriosclerosis, thrombosis, and vascular biology, 17(3), 595-9. LIPPINCOTT WILLIAMS & WILKINS
Arteriosclerosis Thrombosis & Vascular Biology, 595-599. Lippincott Williams & Wilkins (Wolters Kluwer)
ISSUE=17;STARTPAGE=595;ENDPAGE=599;ISSN=1079-5642;TITLE=Arteriosclerosis Thrombosis & Vascular Biology

Abstract This report describes the association between a frequent mutation in the lipoprotein lipase ( LPL ) gene and HDL cholesterol levels. It concerns a previously described defect that predicts a premature truncation of the LPL protein (447stop).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27bac30f9f612b95f8b10a791c13469
https://research.vu.nl/en/publications/820f611c-8a47-4789-b6af-391b57f8023a