Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Björn Borgström"'
Autor:
Xiaoli Huang, Björn Borgström, John Stegmayr, Yasmin Abassi, Monika Kruszyk, Hakon Leffler, Lo Persson, Sebastian Albinsson, Ramin Massoumi, Ivan G. Scheblykin, Cecilia Hegardt, Stina Oredsson, Daniel Strand
Publikováno v:
ACS Central Science, Vol 4, Iss 6, Pp 760-767 (2018)
Externí odkaz:
https://doaj.org/article/ba15638447014ecdbdcc6989d05998f4
Autor:
Lisbeth Nielsen Fink, Nina Buch-Månson, Knud J. Jensen, Narendra Kumar Mishra, Niels Vrang, Søren L. Pedersen, Karin Mannerstedt, Keld Fosgerau, Thomas Brimert, Philip J. Pedersen, Priska Le-Huu, Charlotte Madsen, Ebbe Engholm, Björn Borgström, Morten Lundh
Publikováno v:
Chemistry – A European Journal. 27:3166-3176
A glucose responsive insulin (GRI) that responds to changes in blood glucose concentrations has remained an elusive goal. Here we describe the development of glucose cleavable linkers based on hydrazone and thiazolidine structures. We developed linke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1652c966395346e739b27aaa9084a02
https://doi.org/10.1002/chem.202004878
https://doi.org/10.1002/chem.202004878
Autor:
Alicja Urbaniak, Joanna Wietrzyk, Timothy C. Chambers, Adam Huczyński, Ewa Maj, Michał Antoszczak, Björn Borgström, Daniel Strand, Youzhong Yuan, Magdalena Delgado
Publikováno v:
European Journal of Medicinal Chemistry. 156:510-523
The polyether ionophore salinomycin has recently captured much interest due to its potent activity against multi-drug resistant cancer cells and cancer stem cells. Previous studies have shown that either acylation of the C20 position or esterificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a2e59eef5935c1018761173eeecaae1
https://doi.org/10.1016/j.ejmech.2018.07.021
https://doi.org/10.1016/j.ejmech.2018.07.021
Autor:
Johannes Klose, Claudia Volz, Björn Borgström, Stina Oredsson, Daniel Strand, Thomas Schmidt, Alexis Ulrich, Martin Schneider, Sarah Kattner
Publikováno v:
Biochemical and Biophysical Research Communications. 495:53-59
Salinomycin, a polyether antibiotic, is a well-known inhibitor of human cancer stem cells. Chemical modification of the allylic C20 hydroxyl of salinomycin has enabled access to synthetic analogs that display increased cytotoxic activity compared to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746afdc5fa77b3156daff9ab3f772491
https://doi.org/10.1016/j.bbrc.2017.10.147
https://doi.org/10.1016/j.bbrc.2017.10.147
Autor:
Stina Oredsson, Ewa Maj, Adam Huczyński, Daniel Strand, Björn Borgström, Joanna Wietrzyk, Michał Antoszczak
Publikováno v:
Tetrahedron Letters. 58:2396-2399
Efficient methods for the synthesis of C2-symmetric dimers of salinomycin joined at either the C1 or C20 positions are reported. Similarly to the native structure, the C20-O-terephthalate dimer displayed activity in the low μM range against a series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a7c6690ee45141b876f9580de5785ed
https://doi.org/10.1016/j.tetlet.2017.05.023
https://doi.org/10.1016/j.tetlet.2017.05.023
Publikováno v:
Chemistry - A European Journal. 23:2077-2083
The ionophore salinomycin has attracted attention for its exceptional ability to selectively reduce the proportion of cells with stem-like properties in cancer cell populations of varying origin. Targeting the tumorigenicity of such cells is of inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6120f9c5b939e5be32e3a3036d598fc
https://doi.org/10.1002/chem.201603621
https://doi.org/10.1002/chem.201603621
Autor:
Hakon Leffler, Björn Borgström, Cecilia Hegardt, Lo Persson, Xiaoli Huang, Ivan G. Scheblykin, John Stegmayr, Ramin Massoumi, Stina Oredsson, Daniel Strand, Yasmin Abassi, Sebastian Albinsson, Monika Kruszyk
Publikováno v:
ACS Central Science
ACS Central Science, Vol 4, Iss 6, Pp 760-767 (2018)
ACS Central Science, Vol 4, Iss 6, Pp 760-767 (2018)
Tumors are phenotypically heterogeneous and include subpopulations of cancer cells with stemlike properties. The natural product salinomycin, a K+-selective ionophore, was recently found to exert selectivity against such cancer stem cells. This selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2240251a4a6da3ad11fc95c5fa12a77b
https://pubmed.ncbi.nlm.nih.gov/29974072
https://pubmed.ncbi.nlm.nih.gov/29974072
Autor:
Magdalena Delgado, Timothy C. Chambers, Daniel Strand, Adam Huczyński, Alicja Urbaniak, Björn Borgström, Michał Antoszczak
Publikováno v:
ResearcherID
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::616702472a98a4b18477d0731655c53d
https://doi.org/10.1096/fasebj.2018.32.1_supplement.836.15
https://doi.org/10.1096/fasebj.2018.32.1_supplement.836.15
Autor:
Linda K. Månsson, Lo Persson, Stina Oredsson, Daniel Strand, Cecilia Hegardt, Xiaoli Huang, Björn Borgström
Publikováno v:
ACS Chemical Biology. 9:1587-1594
Salinomycin, a naturally occurring polyether ionophore was recently found to selectively reduce the proportion of CD44(+)/CD24(-) cells, a phenotype associated with breast cancer stem cells. Subsequent studies from our group showed that chemical modi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41ce89d35cdcd8538fbd7e48aa9c48c1
https://doi.org/10.1021/cb5002153
https://doi.org/10.1021/cb5002153
The polyether ionophore salinomycin has recently gained attention due to its exceptional ability to selectively reduce the proportion of cancer stem cells within a number of cancer cell lines. Efficient single step strategies for the preparation of h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4379c3fbf731f55b84243f31b57e00d
https://europepmc.org/articles/PMC4904257/
https://europepmc.org/articles/PMC4904257/
