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Akademický článek

Mammalian perfusion cultivation at high L-Arginine concentration for efficient production of recombinant protein by increasing perfusion filter transmission.

Autor: Poulsen BR; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark. Electronic address: bjrp@novonordisk.com., Egebjerg T; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark., Noebel M; CMC API Development, Novo Nordisk A/S, Hilleroed, Denmark., Thorsen K; CMC API Development, Novo Nordisk A/S, Hilleroed, Denmark., Nilsson CN; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark., Bjelke JR; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark.

Publikováno v: Journal of biotechnology [J Biotechnol] 2024 Nov 20; Vol. 395, pp. 80-83. Date of Electronic Publication: 2024 Sep 17.

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Akademický článek

Nonspecificity fingerprints for clinical-stage antibodies in solution.

Autor: Herling TW; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom., Invernizzi G; Global Research Technologies, Novo Nordisk A/S, Måløv 2760, Denmark., Ausserwöger H; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom., Bjelke JR; Global Research Technologies, Novo Nordisk A/S, Måløv 2760, Denmark., Egebjerg T; Global Research Technologies, Novo Nordisk A/S, Måløv 2760, Denmark., Lund S; Global Research Technologies, Novo Nordisk A/S, Måløv 2760, Denmark., Lorenzen N; Global Research Technologies, Novo Nordisk A/S, Måløv 2760, Denmark., Knowles TPJ; Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom.; Department of Physics, University of Cambridge, Cambridge CB3 0HE, United Kingdom.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Dec 26; Vol. 120 (52), pp. e2306700120. Date of Electronic Publication: 2023 Dec 18.

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Akademický článek

The functional role of the autolysis loop in the regulation of factor X upon hemostatic response.

Autor: Bonde AC; Global Research, Novo Nordisk A/S, Måløv, Denmark.; Section for Biomolecular Sciences, Department of Biology, University of Copenhagen, Copenhagen N, Denmark., Lund J; Global Research, Novo Nordisk A/S, Måløv, Denmark., Hansen JJ; Global Research, Novo Nordisk A/S, Måløv, Denmark., Winther JR; Section for Biomolecular Sciences, Department of Biology, University of Copenhagen, Copenhagen N, Denmark., Nielsen PF; Global Research, Novo Nordisk A/S, Måløv, Denmark., Zahn S; Global Research, Novo Nordisk A/S, Måløv, Denmark., Tiainen P; Global Research, Novo Nordisk A/S, Måløv, Denmark., Olsen OH; Novo Nordisk Foundation Centre for Basic Metabolic Research, University of Copenhagen, Copenhagen N, Denmark., Petersen HH; Research and Development, LEO Pharma, Ballerup, Denmark., Bjelke JR; Global Research, Novo Nordisk A/S, Måløv, Denmark.

Publikováno v: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2022 Mar; Vol. 20 (3), pp. 589-599. Date of Electronic Publication: 2022 Jan 03.

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Akademický článek

The alpha/B.1.1.7 SARS-CoV-2 variant exhibits significantly higher affinity for ACE-2 and requires lower inoculation doses to cause disease in K18-hACE2 mice.

Autor: Bayarri-Olmos R; Recombinant Protein and Antibody Laboratory, Copenhagen University Hospital, Copenhagen, Denmark.; Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark., Johnsen LB; Novo Nordisk A/S, Måløv, Denmark., Idorn M; Department of Biomedicine, Aarhus University, Århus, Denmark., Reinert LS; Department of Biomedicine, Aarhus University, Århus, Denmark., Rosbjerg A; Recombinant Protein and Antibody Laboratory, Copenhagen University Hospital, Copenhagen, Denmark.; Institute of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark., Vang S; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark., Hansen CB; Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark., Helgstrand C; Novo Nordisk A/S, Måløv, Denmark., Bjelke JR; Novo Nordisk A/S, Måløv, Denmark., Bak-Thomsen T; Novo Nordisk A/S, Måløv, Denmark., Paludan SR; Department of Biomedicine, Aarhus University, Århus, Denmark., Garred P; Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark., Skjoedt MO; Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark.; Institute of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.

Publikováno v: ELife [Elife] 2021 Nov 25; Vol. 10. Date of Electronic Publication: 2021 Nov 25.

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Akademický článek

A factor VIIIa-mimetic bispecific antibody, Mim8, ameliorates bleeding upon severe vascular challenge in hemophilia A mice.

Autor: Østergaard H; Global Drug Discovery and., Lund J; Global Drug Discovery and., Greisen PJ; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark; and., Kjellev S; Global Drug Discovery and., Henriksen A; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark; and., Lorenzen N; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark; and., Johansson E; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark; and., Røder G; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark; and., Rasch MG; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark; and., Johnsen LB; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark; and., Egebjerg T; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark; and., Lund S; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark; and., Rahbek-Nielsen H; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark; and., Gandhi PS; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark; and., Lamberth K; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark; and., Loftager M; Global Drug Discovery and., Andersen LM; Global Drug Discovery and., Bonde AC; Global Drug Discovery and., Stavenuiter F; Global Drug Discovery and., Madsen DE; Global Drug Discovery and., Li X; Discovery Technology China, Novo Nordisk A/S, Beijing, China., Holm TL; Global Drug Discovery and., Ley CD; Global Drug Discovery and., Thygesen P; Global Drug Discovery and., Zhu H; Discovery Technology China, Novo Nordisk A/S, Beijing, China., Zhou R; Discovery Technology China, Novo Nordisk A/S, Beijing, China., Thorn K; Global Drug Discovery and., Yang Z; Discovery Technology China, Novo Nordisk A/S, Beijing, China., Hermit MB; Global Drug Discovery and., Bjelke JR; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark; and., Hansen BG; Global Research Technologies, Novo Nordisk A/S, Maaloev, Denmark; and., Hilden I; Global Drug Discovery and.

Publikováno v: Blood [Blood] 2021 Oct 07; Vol. 138 (14), pp. 1258-1268.

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Akademický článek

Design of Biopharmaceutical Formulations Accelerated by Machine Learning.

Autor: Narayanan H; Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, Swiss Federal Institute of Technology, 8093 Zurich, Switzerland., Dingfelder F; Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, Swiss Federal Institute of Technology, 8093 Zurich, Switzerland.; Department of Biophysics and Injectable Formulation, Global Research Technologies, Novo Nordisk A/S, Måløv 2760, Denmark., Condado Morales I; Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, Swiss Federal Institute of Technology, 8093 Zurich, Switzerland.; Department of Biophysics and Injectable Formulation, Global Research Technologies, Novo Nordisk A/S, Måløv 2760, Denmark., Patel B; Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, Swiss Federal Institute of Technology, 8093 Zurich, Switzerland., Heding KE; Department of Biophysics and Injectable Formulation, Global Research Technologies, Novo Nordisk A/S, Måløv 2760, Denmark., Bjelke JR; Department of Purification Technologies, Global Research Technologies, Novo Nordisk A/S, Måløv 2760, Denmark., Egebjerg T; Department of Mammalian Expression, Global Research Technologies, Novo Nordisk A/S, Måløv 2760, Denmark., Butté A; DataHow AG, Zürichstrasse 137, 8600 Dübendorf, Switzerland., Sokolov M; DataHow AG, Zürichstrasse 137, 8600 Dübendorf, Switzerland., Lorenzen N; Department of Biophysics and Injectable Formulation, Global Research Technologies, Novo Nordisk A/S, Måløv 2760, Denmark., Arosio P; Department of Chemistry and Applied Biosciences, Institute for Chemical and Bioengineering, Swiss Federal Institute of Technology, 8093 Zurich, Switzerland.

Publikováno v: Molecular pharmaceutics [Mol Pharm] 2021 Oct 04; Vol. 18 (10), pp. 3843-3853. Date of Electronic Publication: 2021 Sep 14.

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Akademický článek

SARS-CoV-2 Neutralizing Antibody Responses towards Full-Length Spike Protein and the Receptor-Binding Domain.

Autor: Bayarri-Olmos R; Copenhagen University Hospital, Copenhagen, Denmark; rafael.bayarri.olmos@regionh.dk., Idorn M; Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University, Aarhus, Denmark., Rosbjerg A; Copenhagen University Hospital, Copenhagen, Denmark., Pérez-Alós L; Copenhagen University Hospital, Copenhagen, Denmark., Hansen CB; Copenhagen University Hospital, Copenhagen, Denmark., Johnsen LB; Novo Nordisk, Måløv, Denmark., Helgstrand C; Novo Nordisk, Måløv, Denmark., Zosel F; Novo Nordisk, Måløv, Denmark., Bjelke JR; Novo Nordisk, Måløv, Denmark., Öberg FK; Novo Nordisk, Måløv, Denmark., Søgaard M; ExpreS2ion Biotechnologies, Horsholm, Denmark., Paludan SR; Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University, Aarhus, Denmark., Bak-Thomsen T; Novo Nordisk, Måløv, Denmark., Jardine JG; Neutralizing Antibody Center, Scripps Research, International AIDS Vaccine Initiative, La Jolla, CA; and., Skjoedt MO; Copenhagen University Hospital, Copenhagen, Denmark., Garred P; Copenhagen University Hospital, Copenhagen, Denmark.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2021 Aug 01; Vol. 207 (3), pp. 878-887. Date of Electronic Publication: 2021 Jul 23.

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