Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Bjarte Mortensen"'
Autor:
Joakim Håkansson, Bjarte Mortensen, John-Sigurd Svendsen, Wenche Stensen, Johan Svenson, Jorunn Pauline Cavanagh
Publikováno v:
The Journal of Antibiotics. 74:337-345
Synthetic mimics of antimicrobial peptides (AMPs) is a promising class of molecules for a variety of antimicrobial applications. Several hurdles must be passed before effective systemic infection therapies with AMPs can be achieved, but the path to e
Autor:
Guillaume Serin, Bjarte Mortensen, John S. Svendsen, Øystein Rekdal, Ketil André Camilio, Liv Tone Eliassen, Kristel Berg, Bengt Erik Haug, Jean-Francois Mirjolet, Wenche Stensen, Francis Bichat
Publikováno v:
Journal of Medicinal Chemistry. 59:2918-2927
Oncolytic immunotherapies represent a new promising strategy in the treatment of cancer. In our efforts to develop oncolytic peptides, we identified a series of chemically modified 9-mer cationic peptides that were highly effective against both drug-
Publikováno v:
Microbial Ecology in Health and Disease; Vol 17, No 2 (2005)
It has previously been claimed that nitrite protects against infections caused by Candida albicans. Nitrate and nitrite are natural constituents of saliva. The aim of the present study was to investigate if patients with oral candidosis have amounts
Publikováno v:
Pharmacology & Toxicology. 83:49-56
Surveys of Norwegian industrial occupational atmosphere between 1983 to 1996, have identified the 12 most frequent occurring binary combinations of volatile organic chemicals. These combinations were tested in vitro for mutual inhibition or enhanceme
Publikováno v:
Pharmacology & Toxicology. 82:67-71
Methyl ethyl ketone pretreatment induced rat liver cytochrome P450 and increased significantly the in vitro metabolism of n-hexane and the formation of 2,5-hexanedione in rat liver S9. No significant changes were, however, found in the levels of the
Publikováno v:
Archives of toxicology. 74(6)
In vitro rates of metabolism and Michaelis-Menten constants were determined for 25 different C6 to C10 hydrocarbons using rat liver slices in a vial head-space equilibration system. The rates of metabolism were compared with steady-state levels obtai
Publikováno v:
Pharmacologytoxicology. 84(3)
This study was conducted to investigate if biotransformation of N,N,N-triethylene-thiophosphoramide (thio-TEPA) by liver slice incubations reflects the established gender pattern for rat and mouse. Liver slices from rat and mice of both genders were
Autor:
Odd G. Nilsen, Bjarte Mortensen
Publikováno v:
Pharmacologytoxicology. 82(4)
The liver S9 head space vial equilibration technique is an in vitro alternative that holds promises for a satisfactory in vivo extrapolation of liver metabolism of volatile organic chemicals. The aim of this study was to investigate the suitability o
Autor:
Odd G. Nilsen, Bjarte Mortensen
Publikováno v:
Pharmacologytoxicology. 82(3)
A head space liver S9 vial equilibration technique for qualitative and quantitative metabolism of volatile organic solvents in vitro is described and investigated for optimal experimental conditions with toluene and n-hexane as model substrates. The
Publikováno v:
Pharmacologytoxicology. 81(1)
In vitro systems of high biological organization, e.g. containing intact hepatocytes, have been considered as more reliable for metabolic studies and in vivo predictions of toxicokinetics than subcellular systems. For this reason, the kinetics and me