Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Bjarni J. Vilhjálmsson"'
Autor:
Trine Munk-Olsen, Arianna Di Florio, Kathrine B. Madsen, Clara Albiñana, Merete L. Mægbæk, Veerle Bergink, Vibe G. Frøkjær, Esben Agerbo, Bjarni J. Vilhjálmsson, Thomas Werge, Merete Nordentoft, David M. Hougaard, Anders D. Børglum, Ole Mors, Preben Bo Mortensen, Xiaoqin Liu
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract It remains inconclusive whether postpartum depression (PPD) and depression with onset outside the postpartum period (MDD) are genetically distinct disorders. We aimed to investigate whether polygenic risk scores (PGSs) for major mental disor
Externí odkaz:
https://doaj.org/article/55dd8d9090d14f2ea460f664133aba97
Autor:
Emil M. Pedersen, Esben Agerbo, Oleguer Plana-Ripoll, Jette Steinbach, Morten D. Krebs, David M. Hougaard, Thomas Werge, Merete Nordentoft, Anders D. Børglum, Katherine L. Musliner, Andrea Ganna, Andrew J. Schork, Preben B. Mortensen, John J. McGrath, Florian Privé, Bjarni J. Vilhjálmsson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Proportional hazards models have been proposed to analyse time-to-event phenotypes in genome-wide association studies (GWAS). However, little is known about the ability of proportional hazards models to identify genetic associations under di
Externí odkaz:
https://doaj.org/article/eb3d95affd73451ea109b0d277fe474f
Autor:
Clara Albiñana, Zhihong Zhu, Andrew J. Schork, Andrés Ingason, Hugues Aschard, Isabell Brikell, Cynthia M. Bulik, Liselotte V. Petersen, Esben Agerbo, Jakob Grove, Merete Nordentoft, David M. Hougaard, Thomas Werge, Anders D. Børglum, Preben Bo Mortensen, John J. McGrath, Benjamin M. Neale, Florian Privé, Bjarni J. Vilhjálmsson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract The predictive performance of polygenic scores (PGS) is largely dependent on the number of samples available to train the PGS. Increasing the sample size for a specific phenotype is expensive and takes time, but this sample size can be effec
Externí odkaz:
https://doaj.org/article/65c6fd7da745423fbb7f56199da61c83
Autor:
Clara Albiñana, Zhihong Zhu, Nis Borbye-Lorenzen, Sanne Grundvad Boelt, Arieh S. Cohen, Kristin Skogstrand, Naomi R. Wray, Joana A. Revez, Florian Privé, Liselotte V. Petersen, Cynthia M. Bulik, Oleguer Plana-Ripoll, Katherine L. Musliner, Esben Agerbo, Anders D. Børglum, David M. Hougaard, Merete Nordentoft, Thomas Werge, Preben Bo Mortensen, Bjarni J. Vilhjálmsson, John J. McGrath
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The vitamin D binding protein (DBP), encoded by the group-specific component (GC) gene, is a component of the vitamin D system. In a genome-wide association study of DBP concentration in 65,589 neonates we identify 26 independent loci, 17 of
Externí odkaz:
https://doaj.org/article/15845a4d45ac43fd9c945f9f49a9c9cc
Autor:
Clara Albiñana, Zhihong Zhu, Nis Borbye-Lorenzen, Sanne Grundvad Boelt, Arieh S. Cohen, Kristin Skogstrand, Naomi R. Wray, Joana A. Revez, Florian Privé, Liselotte V. Petersen, Cynthia M. Bulik, Oleguer Plana-Ripoll, Katherine L. Musliner, Esben Agerbo, Anders D. Børglum, David M. Hougaard, Merete Nordentoft, Thomas Werge, Preben Bo Mortensen, Bjarni J. Vilhjálmsson, John J. McGrath
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/9a04756801ae4be7b59d11f637177242
Publikováno v:
HGG Advances, Vol 3, Iss 4, Pp 100136- (2022)
Summary: Publicly available genome-wide association studies (GWAS) summary statistics exhibit uneven quality, which can impact the validity of follow-up analyses. First, we present an overview of possible misspecifications that come with GWAS summary
Externí odkaz:
https://doaj.org/article/422e9b5d08034812845b0a504ffe9136
Autor:
Hanna Julienne, Vincent Laville, Zachary R McCaw, Zihuai He, Vincent Guillemot, Carla Lasry, Andrey Ziyatdinov, Cyril Nerin, Amaury Vaysse, Pierre Lechat, Hervé Ménager, Wilfried Le Goff, Marie-Pierre Dube, Peter Kraft, Iuliana Ionita-Laza, Bjarni J Vilhjálmsson, Hugues Aschard
Publikováno v:
PLoS Genetics, Vol 17, Iss 8, p e1009713 (2021)
Genome-wide association studies (GWASs) have uncovered a wealth of associations between common variants and human phenotypes. Here, we present an integrative analysis of GWAS summary statistics from 36 phenotypes to decipher multitrait genetic archit
Externí odkaz:
https://doaj.org/article/5c9ea5db0c81433a97c3f01fff044602
Autor:
Tristan J Hayeck, George B Busby, Sung Chun, Anna C F Lewis, Megan C Roberts, Bjarni J Vilhjálmsson
Publikováno v:
Hayeck, T J, Busby, G B, Chun, S, Lewis, A C F, Roberts, M C & Vilhjálmsson, B J 2023, ' Polygenic Risk Scores : Genomes to Risk Prediction ', Clinical Chemistry . https://doi.org/10.1093/clinchem/hvad049
Autor:
Yi Ding, Kangcheng Hou, Ziqi Xu, Aditya Pimplaskar, Ella Petter, Kristin Boulier, Florian Privé, Bjarni J. Vilhjálmsson, Loes M. Olde Loohuis, Bogdan Pasaniuc
Publikováno v:
Nature, vol 618, iss 7966
Ding, Y, Hou, K, Xu, Z, Pimplaskar, A, Petter, E, Boulier, K, Privé, F, Vilhjálmsson, B J, Olde Loohuis, L M & Pasaniuc, B 2023, ' Polygenic scoring accuracy varies across the genetic ancestry continuum ', Nature, vol. 618, pp. 774-781 . https://doi.org/10.1038/s41586-023-06079-4
Ding, Y, Hou, K, Xu, Z, Pimplaskar, A, Petter, E, Boulier, K, Privé, F, Vilhjálmsson, B J, Olde Loohuis, L M & Pasaniuc, B 2023, ' Polygenic scoring accuracy varies across the genetic ancestry continuum ', Nature, vol. 618, pp. 774-781 . https://doi.org/10.1038/s41586-023-06079-4
Polygenic scores (PGSs) have limited portability across different groupings of individuals (for example, by genetic ancestries and/or social determinants of health), preventing their equitable use1–3. PGS portability has typically been assessed usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228435a6191fd5baceca508fb65d8edf
https://escholarship.org/uc/item/4m17p3jq
https://escholarship.org/uc/item/4m17p3jq
Autor:
Nis P. Suppli, Anders D. Børglum, Esben Agerbo, Jonas Bybjerg-Grauholm, Katherine L. Musliner, Marianne Giørtz Pedersen, Trine Munk-Olsen, Veera M. Rajagopal, Marie Bækved-Hansen, Thomas Damm Als, Jakob Grove, Klaus Kaae Andersen, Preben Bo Mortensen, Bjarni J. Vilhjálmsson, Clara Albiñana, Carsten Bøcker Pedersen, Ole Mors, David M. Hougaard, Merete Nordentoft, Thomas Werge, Michael E. Benros
Publikováno v:
Musliner, K L, Andersen, K K, Agerbo, E, Albiñana, C, Vilhjalmsson, B J, Rajagopal, V M, Bybjerg-Grauholm, J, Bækved-Hansen, M, Pedersen, C B, Pedersen, M G, Munk-Olsen, T, Benros, M E, Als, T D, Grove, J, Werge, T, Børglum, A D, Hougaard, D M, Mors, O, Nordentoft, M, Mortensen, P B, Suppli, N P & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2023, ' Polygenic liability, stressful life events and risk for secondary-treated depression in early life : a nationwide register-based case-cohort study ', Psychological Medicine, vol. 53, no. 1, pp. 217-226 . https://doi.org/10.1017/S0033291721001410
BackgroundIn this study, we examined the relationship between polygenic liability for depression and number of stressful life events (SLEs) as risk factors for early-onset depression treated in inpatient, outpatient or emergency room settings at psyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8254a17d31e17a662469c7732e109a51
https://pure.au.dk/portal/da/publications/polygenic-liability-stressful-life-events-and-risk-for-secondarytreated-depression-in-early-life(34c1ee24-ac60-4216-9127-94f48cc6f5f8).html
https://pure.au.dk/portal/da/publications/polygenic-liability-stressful-life-events-and-risk-for-secondarytreated-depression-in-early-life(34c1ee24-ac60-4216-9127-94f48cc6f5f8).html