Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Bjarne W, Kristensen"'
Autor:
Inès C. N. Avenel, Jesper D. Ewald, Jérémy Ariey-Bonnet, Ida H. Kristensen, Stine A. Petterson, Martin N. Thesbjerg, Mark Burton, Mads Thomassen, Krister Wennerberg, Signe R. Michaelsen, Bjarne W. Kristensen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Glioblastoma is the most common primary brain tumor in adults, characterized by an inherent aggressivity and resistance to treatment leading to poor prognoses. While some resistance mechanisms have been elucidated, a deeper understanding of
Externí odkaz:
https://doaj.org/article/bf399aa8474f412ba51abb1b4e7f7711
Autor:
Rikke H. Dahlrot, Julie A. Bangsø, Jeanette K. Petersen, Ann Mari Rosager, Mia D. Sørensen, Guido Reifenberger, Steinbjørn Hansen, Bjarne W. Kristensen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Survival of glioblastoma patients varies and prognostic markers are important in the clinical setting. With digital pathology and improved immunohistochemical multiplexing becoming a part of daily diagnostics, we investigated the prognostic
Externí odkaz:
https://doaj.org/article/e9d2b1e38f8143a7b7f811815123cf89
Autor:
Sajina Shakya, Anthony D. Gromovsky, James S. Hale, Arnon M. Knudsen, Briana Prager, Lisa C. Wallace, Luiz O. F. Penalva, H. Alex Brown, Bjarne W. Kristensen, Jeremy N. Rich, Justin D. Lathia, J. Mark Brown, Christopher G. Hubert
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)
Abstract Glioblastoma (GBM) displays marked cellular and metabolic heterogeneity that varies among cellular microenvironments within a tumor. Metabolic targeting has long been advocated as a therapy against many tumors including GBM, but how lipid me
Externí odkaz:
https://doaj.org/article/f740fb738c5c45e4ad68a8ab8f9b28c9
Autor:
Bettina H. Clausen, Martin Wirenfeldt, Sofie S. Høgedal, Lars H. Frich, Helle H. Nielsen, Henrik D. Schrøder, Kamilla Østergaard, Bente Finsen, Bjarne W. Kristensen, Kate L. Lambertsen
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-17 (2020)
Abstract Preclinical and clinical proof-of-concept studies have suggested the effectiveness of pharmacological modulation of inflammatory cytokines in ischemic stroke. Experimental evidence shows that targeting tumor necrosis factor (TNF) and interle
Externí odkaz:
https://doaj.org/article/3cae400332a44bbd9ebeeae911cf0139
Autor:
Masahiro Hitomi, Anastasia P. Chumakova, Daniel J. Silver, Arnon M. Knudsen, W. Dean Pontius, Stephanie Murphy, Neha Anand, Bjarne W. Kristensen, Justin D. Lathia
Publikováno v:
JCI Insight, Vol 6, Iss 3 (2021)
Asymmetric cell division (ACD) enables the maintenance of a stem cell population while simultaneously generating differentiated progeny. Cancer stem cells (CSCs) undergo multiple modes of cell division during tumor expansion and in response to therap
Externí odkaz:
https://doaj.org/article/bc28c8e103ed4c54bc7d0532f52eaa48
Autor:
Ljudmilla A. G. Nielsen, Julie A. Bangsø, Kim H. Lindahl, Rikke H. Dahlrot, Jacob v. B. Hjelmborg, Steinbjørn Hansen, Bjarne W. Kristensen
Publikováno v:
Diagnostic Pathology, Vol 13, Iss 1, Pp 1-8 (2018)
Abstract Background The Ki-67 Labelling Index (LI) is used as an ancillary tool in glioma diagnostics. Interobserver variability has been reported and no precise guidelines are available. Nor is it known whether novel digital approaches would be an a
Externí odkaz:
https://doaj.org/article/f8cd8b7e81f3471194f271c52a974f7f
Autor:
Charlotte Aaberg-Jessen, Mia D. Sørensen, Ana L. S. A. Matos, José M. Moreira, Nils Brünner, Arnon Knudsen, Bjarne W. Kristensen
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-16 (2018)
Abstract Background We have previously identified tissue inhibitor of metalloproteinases-1 (TIMP-1) as a prognostic marker in glioblastomas. TIMP-1 has been associated with chemotherapy resistance, and CD63, a known TIMP-1-binding protein, has been s
Externí odkaz:
https://doaj.org/article/cd2be74ab6b34f708de1601d26d6e461
Autor:
Andrea D. Maier, Alessandra Meddis, Christian Mirian, Jeppe Haslund-Vinding, Jiri Bartek, Sebastian M. Krog, Thi Uyen Phuong Nguyen, Aušrinė Areškevičiūtė, Linea C. Melchior, Steffen Heegaard, Bjarne W. Kristensen, Tina N. Munch, Kåre Fugleholm, Morten Ziebell, David R. Raleigh, Frantz R. Poulsen, Thomas A. Gerds, Thomas Litman, David Scheie, Tiit Mathiesen
Publikováno v:
Journal of Neurosurgery. :1-11
OBJECTIVE Meningioma is the most common primary intracranial neoplasm. Only 1%–3% of meningiomas are malignant according to the 2016 WHO criteria (WHO grade III). High-grade meningiomas present specific gene expression signatures indicating aggress
Autor:
Feng Lin, Thomas M. McIntyre, Guido Reifenberger, Bjarne W. Kristensen, Mia D. Sorensen, Lingjun Zhang
Purpose: Somatic mutations in the isocitrate dehydrogenase (IDH)-1 and -2 genes are remarkably penetrant in diffuse gliomas. These highly effective gain-of-function mutations enable mutant IDH to efficiently metabolize isocitrate to D-2-hydroxyglutar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0433498da0ebaed757d10f6e07c33457
https://doi.org/10.1158/1078-0432.c.6528866
https://doi.org/10.1158/1078-0432.c.6528866
Autor:
Feng Lin, Thomas M. McIntyre, Guido Reifenberger, Bjarne W. Kristensen, Mia D. Sorensen, Lingjun Zhang
Summary of the immunohistochemical staining results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::786efc327d46f383dbced6858185c837
https://doi.org/10.1158/1078-0432.22474670
https://doi.org/10.1158/1078-0432.22474670