Výsledky vyhledávání - "Bjarne Vincents"

Hyperactive antifreeze proteins from longhorn beetles: Some structural insights

Autor: Bjarne Vincents, Anders Løbner-Olesen, Dennis Steven Friis, Casper Wilkens, Erlend Kristiansen, Hans Ramløv, Anders Blomkild Lorentzen, Håvard Jenssen

Publikováno v: Journal of Insect Physiology. 58:1502-1510

This study reports on structural characteristics of hyperactive antifreeze proteins (AFPs) from two species of longhorn beetles. In Rhagium mordax, eight unique mRNAs coding for five different mature AFPs were identified from cold-hardy individuals.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eada0eefc74c0604189a9fd887b19a97
https://doi.org/10.1016/j.jinsphys.2012.09.004

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Cleavage of IgG1 in gingival crevicular fluid is associated with the presence ofPorphyromonas gingivalis

Autor: Magnus Abrahamson, Arndt Guentsch, Wolfgang Pfister, Aneta Sroka, Bjarne Vincents, Sigrun Eick, Jan Potempa, Christiane Hirsch

Publikováno v: Journal of Periodontal Research

Background and Objectives Immunoglobulin (Ig) G1 plays an important role in the adaptive immune response. Kgp, a lysine-specific cysteine protease from Porphyromonas gingivalis, specifically hydrolyses IgG1 heavy chains. The purpose of this study was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006f4e13e6fc4baa9203aa12d9ec3472

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The Human Protease Inhibitor Cystatin C Is an Activating Cofactor for the Streptococcal Cysteine Protease IdeS

Autor: Ulrich von Pawel-Rammingen, Bjarne Vincents, Reine Vindebro, Magnus Abrahamson

Publikováno v: Chemistry & Biology. 15:960-968

SummaryHuman cystatin C is considered the physiologically most important inhibitor of endogenous papain-like cysteine proteases. We present here an unexpected function of cystatin C. Instead of acting as an inhibitor, cystatin C acts as a facultative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a5fa3a870647931f14c7106874532c
https://doi.org/10.1016/j.chembiol.2008.07.021

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Enzymatic Characterization of the Streptococcal Endopeptidase, IdeS, Reveals That It Is a Cysteine Protease with Strict Specificity for IgG Cleavage Due to Exosite Binding

Autor: Ulrich von Pawel-Rammingen, Bjarne Vincents, Lars Björck, Magnus Abrahamson

Publikováno v: Biochemistry. 43:15540-15549

Streptococcus pyogenes, an important pathogen in humans, secretes an IgG specific endopeptidase named IdeS. To elucidate the mechanism that is responsible for this specificity, we have here characterized the activity of IdeS in detail. Both gamma cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b29d9335d04a4a51ed90e114e746f59b
https://doi.org/10.1021/bi048284d

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K21-Antigen: A Molecule Shared by the Microenvironments of the Human Thymus and Germinal Centers

Autor: Jona Freysdottir, Abdulhamid A. Al-Tubuly, Brian M. J. Foxwell, Moditi L. Sedibane, Heather M. Ladyman, David A. Taylor-Fishwick, Bjarne Vincents, Nesrina Imami, Mary A. Ritter

Publikováno v: Clinical and Developmental Immunology, Vol 6, Iss 1-2, Pp 41-52 (1998)
Scopus-Elsevier
Developmental Immunology

The mouse IgG1 monoclonal antibody (mAb) K21 recognizes a 230-kD molecule (K21-Ag) on Hassall's corpuscles in the human thymus. This mAb also stains cultured thymic epithelial cells as well as other epithelial cell lines, revealing a predominant intr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d0ca590a0cf5b9c71b21bd65975ccd9
https://doaj.org/article/3e3ba00df9d54b128daecfa3848affa3

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Cleavage of IgG1 and IgG3 by gingipain K from Porphyromonas gingivalis may compromise host defense in progressive periodontitis

Autor: Sigrun Eick, Jan Potempa, Arndt Guentsch, Magnus Abrahamson, Bjarne Vincents, Ulrich von Pawel-Rammingen, Dominika Kostolowska

Publikováno v: The FASEB Journal
The FASEB Journal; Vol 25

Degradation of immunoglobulins is an effective strategy of bacteria to evade the immune system. We have tested whether human IgG is a substrate for gingipain K of Porphyromonas gingivalis and found that the enzyme can hydrolyze subclass 1 and 3 of hu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c93722e1a0482693a373bf00133c87d
https://europepmc.org/articles/PMC3177567/

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Down-regulation of human extracellular cysteine protease inhibitors by the secreted staphylococcal cysteine proteases, staphopain A and B

Autor: Jan Potempa, Milosz Gruca, Bjarne Vincents, Magnus Abrahamson, Patrik Önnerfjord

Publikováno v: Biological chemistry. 388(4)

Of seven human cystatins investigated, none inhibited the cysteine proteases staphopain A and B secreted by the human pathogen Staphylococcus aureus. Rather, the extracellular cystatins C, D and E/M were hydrolyzed by both staphopains. Based on MALDI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4389e6a2ac2d4ac7342f0a31de62a3
https://pubmed.ncbi.nlm.nih.gov/17391065

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