Linking metabolic QTLs with network and cis-eQTLs controlling biosynthetic pathways.

Autor: Adam M Wentzell, Heather C Rowe, Bjarne Gram Hansen, Carla Ticconi, Barbara Ann Halkier, Daniel J Kliebenstein

Publikováno v: PLoS Genetics, Vol 3, Iss 9, Pp 1687-1701 (2007)

Phenotypic variation between individuals of a species is often under quantitative genetic control. Genomic analysis of gene expression polymorphisms between individuals is rapidly gaining popularity as a way to query the underlying mechanistic causes

Externí odkaz: https://doaj.org/article/ea7a370f107b4f35858c42d768c29fc1

Aspergillus nidulans synthesize insect juvenile hormones upon expression of a heterologous regulatory protein and in response to grazing by Drosophila melanogaster larvae.

Autor: Morten Thrane Nielsen, Marie Louise Klejnstrup, Marko Rohlfs, Diana Chinyere Anyaogu, Jakob Blæsbjerg Nielsen, Charlotte Held Gotfredsen, Mikael Rørdam Andersen, Bjarne Gram Hansen, Uffe Hasbro Mortensen, Thomas Ostenfeld Larsen

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e73369 (2013)

Secondary metabolites are known to serve a wide range of specialized functions including communication, developmental control and defense. Genome sequencing of several fungal model species revealed that the majority of predicted secondary metabolite

Externí odkaz: https://doaj.org/article/8f54415ad07549319c69283e7dce52cf

A factor VIIIa-mimetic bispecific antibody, Mim8, ameliorates bleeding upon severe vascular challenge in hemophilia A mice

Autor: Peter Thygesen, A. Henriksen, Haisun Zhu, Mette B. Hermit, Laust Bruun Johnsen, Per Jr Greisen, Søren Lund, Henrik Rahbek-Nielsen, Stine Kjellev, Kasper Lamberth, Henrik Østergaard, Eva Johansson, Thomas Lindebo Holm, Jais Rose Bjelke, Prafull S. Gandhi, Carsten Dan Ley, Daniel Elenius Madsen, Nikolai Lorenzen, Lisbeth Moreau Andersen, Zhiru Yang, Gustav Røder, Jacob Lund, Mette Loftager, Bjarne Gram Hansen, Amalie Carnbring Bonde, Rong Zhou, Ida Hilden, Thomas Egebjerg, Karina Thorn, Morten Grønbech Rasch, Xun Li, Fabian Stavenuiter

Publikováno v: Blood

Østergaard and colleagues report the development of a potent bispecific antibody, Mim8, which binds both activated factor IX and factor X, mimicking the propagation of coagulation by activated factor VIII. They detail biophysical, in vitro, and in v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e433ece5cb66919dedef92b8e13f3d4
https://pubmed.ncbi.nlm.nih.gov/34077951

Kinetically Controlled Drug Resistance

Autor: Bjarne Gram Hansen, Xin E. Sun, Lizbeth Hedstrom

Publikováno v: Journal of Biological Chemistry. 286:40595-40600

The filamentous fungus Penicillium brevicompactum produces the immunosuppressive drug mycophenolic acid (MPA), which is a potent inhibitor of eukaryotic IMP dehydrogenases (IMPDHs). IMPDH catalyzes the conversion of IMP to XMP via a covalent enzyme i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97840abae2de0f0ba9b7b31497a53998
https://doi.org/10.1074/jbc.m111.305235

PHUSER (Primer Help for USER): a novel tool for USER fusion primer design

Autor: Kiran Raosaheb Patil, Mads Bonde, Simon Carlsen, Bjarne Gram Hansen, Dorte Koefoed Holm, Niels Bjørn Hansen, Rasmus Wernersson, Hans Jasper Genee, Lars R. Olsen, Uffe Hasbro Mortensen

Publikováno v: Olsen, L R, Hansen, N B, Bonde, M, Genee, H J, Holm, D M K, Carlsen, S, Hansen, B G, Patil, K R, Mortensen, U H & Wernersson, R 2011, ' PHUSER (Primer Help for USER): a novel tool for USER fusion primer design ', Nucleic Acids Research, vol. 39, no. Suppl. 2, pp. W61-W67 . https://doi.org/10.1093/nar/gkr394
Olsen, L R, Hansen, B, Bonde, M T, Genee, H J, Holm, D K, Carlsen, S, Hansen, B G, Patil, K R, Mortensen, U H & Wernersson, R 2011, ' PHUSER (Primer Help for USER): a novel tool for USER fusion primer design ', Nucleic Acids Research, vol. 39, no. suppl 2, pp. W61–W67 . https://doi.org/10.1093/nar/gkr394
Nucleic Acids Research

Uracil-Specific Exision Reagent (USER) fusion is a recently developed technique that allows for assembly of multiple DNA fragments in a few simple steps. However, designing primers for USER fusion is both tedious and time consuming. Here, we present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011cb9aa2914075dbb68647d710db3fa
https://doi.org/10.1093/nar/gkr394