Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Bjørn Siteur"'
Autor:
Leonie Ratz, Chiara Brambillasca, Leandra Bartke, Maxim A. Huetzen, Jonas Goergens, Orsolya Leidecker, Ron D. Jachimowicz, Marieke van de Ven, Natalie Proost, Bjørn Siteur, Renske de Korte-Grimmerink, Peter Bouwman, Emilia M. Pulver, Roebi de Bruijn, Jörg Isensee, Tim Hucho, Gaurav Pandey, Maarten van Lohuizen, Peter Mallmann, Hans Christian Reinhardt, Jos Jonkers, Julian Puppe
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-19 (2022)
Abstract Background The majority of BRCA1-mutant breast cancers are characterized by a triple-negative phenotype and a basal-like molecular subtype, associated with aggressive clinical behavior. Current treatment options are limited, highlighting the
Externí odkaz:
https://doaj.org/article/9766126bd94646d0abb634dc3e2d1caa
Autor:
Stefano Annunziato, Julian R. de Ruiter, Linda Henneman, Chiara S. Brambillasca, Catrin Lutz, François Vaillant, Federica Ferrante, Anne Paulien Drenth, Eline van der Burg, Bjørn Siteur, Bas van Gerwen, Roebi de Bruijn, Martine H. van Miltenburg, Ivo J. Huijbers, Marieke van de Ven, Jane E. Visvader, Geoffrey J. Lindeman, Lodewyk F. A. Wessels, Jos Jonkers
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
It is difficult to identify cancer driver genes in cancers, for instance BRCA1 mutated breast cancer, that are characterised by large scale genomic alterations. Here, the authors develop genetically engineered mouse models of BRCA1-deficient breast c
Externí odkaz:
https://doaj.org/article/d9ac65cbd345403caaf37726c9a7d740
Autor:
Aldo Spanjaard, Ronak Shah, Daniël de Groot, Olimpia Alessandra Buoninfante, Ben Morris, Cor Lieftink, Colin Pritchard, Lisa M Zürcher, Shirley Ormel, Joyce J I Catsman, Renske de Korte-Grimmerink, Bjørn Siteur, Natalie Proost, Terry Boadum, Marieke van de Ven, Ji-Ying Song, Maaike Kreft, Paul C M van den Berk, Roderick L Beijersbergen, Heinz Jacobs
Publikováno v:
Nucleic Acids Research. 50:7420-7435
Crosslink repair depends on the Fanconi anemia pathway and translesion synthesis polymerases that replicate over unhooked crosslinks. Translesion synthesis is regulated via ubiquitination of PCNA, and independently via translesion synthesis polymeras
Autor:
Daniel Zingg, Jinhyuk Bhin, Julia Yemelyanenko, Sjors M. Kas, Frank Rolfs, Catrin Lutz, Jessica K. Lee, Sjoerd Klarenbeek, Ian M. Silverman, Stefano Annunziato, Chang S. Chan, Sander R. Piersma, Timo Eijkman, Madelon Badoux, Ewa Gogola, Bjørn Siteur, Justin Sprengers, Bim de Klein, Richard R. de Goeij-de Haas, Gregory M. Riedlinger, Hua Ke, Russell Madison, Anne Paulien Drenth, Eline van der Burg, Eva Schut, Linda Henneman, Martine H. van Miltenburg, Natalie Proost, Huiling Zhen, Ellen Wientjens, Roebi de Bruijn, Julian R. de Ruiter, Ute Boon, Renske de Korte-Grimmerink, Bastiaan van Gerwen, Luis Féliz, Ghassan K. Abou-Alfa, Jeffrey S. Ross, Marieke van de Ven, Sven Rottenberg, Edwin Cuppen, Anne Vaslin Chessex, Siraj M. Ali, Timothy C. Burn, Connie R. Jimenez, Shridar Ganesan, Lodewyk F. A. Wessels, Jos Jonkers
Publikováno v:
Zingg, Daniel; Bhin, Jinhyuk; Yemelyanenko, Julia; Kas, Sjors M; Rolfs, Frank; Lutz, Catrin; Lee, Jessica K; Klarenbeek, Sjoerd; Silverman, Ian M; Annunziato, Stefano; Chan, Chang S; Piersma, Sander R; Eijkman, Timo; Badoux, Madelon; Gogola, Ewa; Siteur, Bjørn; Sprengers, Justin; de Klein, Bim; de Goeij-de Haas, Richard R; Riedlinger, Gregory M; ... (2022). Publisher Correction: Truncated FGFR2 is a clinically actionable oncogene in multiple cancers. Nature, 609(7929), E13. Springer Nature 10.1038/s41586-022-05287-8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42007ac1db1800b2f49158a1d120fdb2
Autor:
Leonie Ratz, Chiara Brambillasca, Leandra Bartke, Marieke van de Ven, Natalie Proost, Bjørn Siteur, Renske de Korte-Grimmerink, Peter Bouwman, Emilia M. Pulver, Roebi de Bruijn, Jörg Isensee, Tim Hucho, Gaurav Pandey, Maarten van Lohuizen, Peter Mallmann, Hans Christian Reinhardt, Jos Jonkers, Julian Puppe
Background: The majority of BRCA1-mutant breast cancers are characterized by a triple-negative phenotype (TNBC) and a basal-like molecular subtype, associated with aggressive clinical behavior. Current treatment options are limited, highlighting the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f470ec6430e484bb1ec851c2324e1c05
https://doi.org/10.21203/rs.3.rs-580939/v1
https://doi.org/10.21203/rs.3.rs-580939/v1
Autor:
Daniel Zingg, Jinhyuk Bhin, Julia Yemelyanenko, Sjors M. Kas, Frank Rolfs, Catrin Lutz, Jessica K. Lee, Sjoerd Klarenbeek, Ian M. Silverman, Stefano Annunziato, Chang S. Chan, Sander R. Piersma, Timo Eijkman, Madelon Badoux, Ewa Gogola, Bjørn Siteur, Justin Sprengers, Bim de Klein, Richard R. de Goeij-de Haas, Gregory M. Riedlinger, Hua Ke, Russell Madison, Anne Paulien Drenth, Eline van der Burg, Eva Schut, Linda Henneman, Martine H. van Miltenburg, Natalie Proost, Huiling Zhen, Ellen Wientjens, Roebi de Bruijn, Julian R. de Ruiter, Ute Boon, Renske de Korte-Grimmerink, Bastiaan van Gerwen, Luis Féliz, Ghassan K. Abou-Alfa, Jeffrey S. Ross, Marieke van de Ven, Sven Rottenberg, Edwin Cuppen, Anne Vaslin Chessex, Siraj M. Ali, Timothy C. Burn, Connie R. Jimenez, Shridar Ganesan, Lodewyk F. A. Wessels, Jos Jonkers
Publikováno v:
Zingg, Daniel; Bhin, Jinhyuk; Yemelyanenko, Julia; Kas, Sjors M; Rolfs, Frank; Lutz, Catrin; Lee, Jessica K; Klarenbeek, Sjoerd; Silverman, Ian M; Annunziato, Stefano; Chan, Chang S; Piersma, Sander R; Eijkman, Timo; Badoux, Madelon; Gogola, Ewa; Siteur, Bjørn; Sprengers, Justin; de Klein, Bim; de Goeij-de Haas, Richard R; Riedlinger, Gregory M; ... (2022). Truncated FGFR2 is a clinically actionable oncogene in multiple cancers. Nature, 608(7923), pp. 609-617. Springer Nature 10.1038/s41586-022-05066-5
Zingg, D, Bhin, J, Yemelyanenko, J, Kas, S M, Rolfs, F, Lutz, C, Lee, J K, Klarenbeek, S, Silverman, I M, Annunziato, S, Chan, C S, Piersma, S R, Eijkman, T, Badoux, M, Gogola, E, Siteur, B, Sprengers, J, de Klein, B, de Goeij-de Haas, R R, Riedlinger, G M, Ke, H, Madison, R, Drenth, A P, van der Burg, E, Schut, E, Henneman, L, van Miltenburg, M H, Proost, N, Zhen, H, Wientjens, E, de Bruijn, R, de Ruiter, J R, Boon, U, de Korte-Grimmerink, R, van Gerwen, B, Féliz, L, Abou-Alfa, G K, Ross, J S, van de Ven, M, Rottenberg, S, Cuppen, E, Chessex, A V, Ali, S M, Burn, T C, Jimenez, C R, Ganesan, S, Wessels, L F A & Jonkers, J 2022, ' Truncated FGFR2 is a clinically actionable oncogene in multiple cancers ', Nature, vol. 608, no. 7923, pp. 609-617 . https://doi.org/10.1038/s41586-022-05066-5
Nature, 608(7923), 609-617. Nature Publishing Group
Zingg, D, Bhin, J, Yemelyanenko, J, Kas, S M, Rolfs, F, Lutz, C, Lee, J K, Klarenbeek, S, Silverman, I M, Annunziato, S, Chan, C S, Piersma, S R, Eijkman, T, Badoux, M, Gogola, E, Siteur, B, Sprengers, J, de Klein, B, de Goeij-de Haas, R R, Riedlinger, G M, Ke, H, Madison, R, Drenth, A P, van der Burg, E, Schut, E, Henneman, L, van Miltenburg, M H, Proost, N, Zhen, H, Wientjens, E, de Bruijn, R, de Ruiter, J R, Boon, U, de Korte-Grimmerink, R, van Gerwen, B, Féliz, L, Abou-Alfa, G K, Ross, J S, van de Ven, M, Rottenberg, S, Cuppen, E, Chessex, A V, Ali, S M, Burn, T C, Jimenez, C R, Ganesan, S, Wessels, L F A & Jonkers, J 2022, ' Truncated FGFR2 is a clinically actionable oncogene in multiple cancers ', Nature, vol. 608, no. 7923, pp. 609-617 . https://doi.org/10.1038/s41586-022-05066-5
Nature, 608(7923), 609-617. Nature Publishing Group
Somatic hotspot mutations and structural amplifications and fusions that affect fibroblast growth factor receptor 2 (encoded by FGFR2) occur in multiple types of cancer1. However, clinical responses to FGFR inhibitors have remained variable1–9, emp
Autor:
Kaspar Bresser, Meike E. W. Logtenberg, Mireille Toebes, Natalie Proost, Justin Sprengers, Bjorn Siteur, Manon Boeije, Lona J. Kroese, Ton N. Schumacher
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
The enzyme glutaminyl-peptide cyclotransferase-like protein (QPCTL) catalyzes the formation of pyroglutamate residues at the NH2-terminus of proteins, thereby influencing their biological properties. A number of studies have implicated QPCTL in the r
Externí odkaz:
https://doaj.org/article/47981d31c5594a39bf65905b145da91d