Výsledky vyhledávání - "Bjørn O, Åsvold"

Akademický článek

The role of cardiovascular risk factors in maternal cardiovascular disease according to offspring birth characteristics in the HUNT study

Autor: Eirin B. Haug, Amanda R. Markovitz, Abigail Fraser, Håvard Dalen, Pål R. Romundstad, Bjørn O. Åsvold, Janet W. Rich-Edwards, Julie Horn

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)

Abstract A history of preterm or small (SGA) or large (LGA) for gestational age offspring is associated with smoking and unfavorable levels of BMI, blood pressure, glucose and lipids. Whether and to what extent the excess cardiovascular risk observed

Externí odkaz: https://doaj.org/article/c5eda03f776b490d906cc68ebcddcf99

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Akademický článek

Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease

Autor: Jonas B. Nielsen, Oren Rom, Ida Surakka, Sarah E. Graham, Wei Zhou, Tanmoy Roychowdhury, Lars G. Fritsche, Sarah A. Gagliano Taliun, Carlo Sidore, Yuhao Liu, Maiken E. Gabrielsen, Anne Heidi Skogholt, Brooke Wolford, William Overton, Ying Zhao, Jin Chen, He Zhang, Whitney E. Hornsby, Akua Acheampong, Austen Grooms, Amanda Schaefer, Gregory J. M. Zajac, Luis Villacorta, Jifeng Zhang, Ben Brumpton, Mari Løset, Vivek Rai, Pia R. Lundegaard, Morten S. Olesen, Kent D. Taylor, Nicholette D. Palmer, Yii-Der Chen, Seung H. Choi, Steven A. Lubitz, Patrick T. Ellinor, Kathleen C. Barnes, Michelle Daya, Nicholas Rafaels, Scott T. Weiss, Jessica Lasky-Su, Russell P. Tracy, Ramachandran S. Vasan, L. Adrienne Cupples, Rasika A. Mathias, Lisa R. Yanek, Lewis C. Becker, Patricia A. Peyser, Lawrence F. Bielak, Jennifer A. Smith, Stella Aslibekyan, Bertha A. Hidalgo, Donna K. Arnett, Marguerite R. Irvin, James G. Wilson, Solomon K. Musani, Adolfo Correa, Stephen S. Rich, Xiuqing Guo, Jerome I. Rotter, Barbara A. Konkle, Jill M. Johnsen, Allison E. Ashley-Koch, Marilyn J. Telen, Vivien A. Sheehan, John Blangero, Joanne E. Curran, Juan M. Peralta, Courtney Montgomery, Wayne H-H Sheu, Ren-Hua Chung, Karen Schwander, Seyed M. Nouraie, Victor R. Gordeuk, Yingze Zhang, Charles Kooperberg, Alexander P. Reiner, Rebecca D. Jackson, Eugene R. Bleecker, Deborah A. Meyers, Xingnan Li, Sayantan Das, Ketian Yu, Jonathon LeFaive, Albert Smith, Tom Blackwell, Daniel Taliun, Sebastian Zollner, Lukas Forer, Sebastian Schoenherr, Christian Fuchsberger, Anita Pandit, Matthew Zawistowski, Sachin Kheterpal, Chad M. Brummett, Pradeep Natarajan, David Schlessinger, Seunggeun Lee, Hyun Min Kang, Francesco Cucca, Oddgeir L. Holmen, Bjørn O. Åsvold, Michael Boehnke, Sekar Kathiresan, Goncalo R. Abecasis, Y. Eugene Chen, Cristen J. Willer, Kristian Hveem

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Drugs targeting cardiovascular disease (CVD) can have negative consequences for liver function. Here, the authors combine genome wide analyses on 69,479 individuals to identify loss-of-function variants with beneficial effects on CVD-related traits w

Externí odkaz: https://doaj.org/article/2eecf9230b454b46b95b45b0f20ddd2e

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Akademický článek

MEPE loss-of-function variant associates with decreased bone mineral density and increased fracture risk

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)

Bone mineral density (BMD) is associated with fracture risk and many genetic loci with small effect sizes have been discovered by genome-wide association studies (GWAS). Here, the authors discover a large-effect rare loss-of-function genetic variant

Externí odkaz: https://doaj.org/article/8fb5a8cdb29342d28a7a71a4a632369b

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Akademický článek

Incorporating Baseline Outcome Data in Individual Participant Data Meta-Analysis of Non-randomized Studies

Publikováno v: Frontiers in Psychiatry, Vol 13 (2022)

BackgroundIn non-randomized studies (NRSs) where a continuous outcome variable (e.g., depressive symptoms) is assessed at baseline and follow-up, it is common to observe imbalance of the baseline values between the treatment/exposure group and contro

Externí odkaz: https://doaj.org/article/292944a31cd141ce863e9f6c008e68cf

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Akademický článek

Incidence, recurring admissions and mortality of severe bacterial infections and sepsis over a 22-year period in the population-based HUNT study.

Autor: Kristin Vardheim Liyanarachi, Erik Solligård, Randi Marie Mohus, Bjørn O Åsvold, Tormod Rogne, Jan Kristian Damås

Publikováno v: PLoS ONE, Vol 17, Iss 7, p e0271263 (2022)

PurposeSevere bacterial infections are important causes of hospitalization and loss of health worldwide. In this study we aim to characterize the total burden, recurrence and severity of bacterial infections in the general population during a 22-year

Externí odkaz: https://doaj.org/article/cb609a7a43c844299fd8e8ade6f1cd46

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Akademický článek

Does pregnancy alter life-course lipid trajectories? Evidence from the HUNT Study in Norway

Autor: Amanda R. Markovitz, Eirin B. Haug, Julie Horn, Abigail Fraser, Corrie Macdonald-Wallis, Kate Tilling, Eric B. Rimm, Stacey A. Missmer, Paige L. Williams, Pål R. Romundstad, Bjørn O. Åsvold, Janet W. Rich-Edwards

Publikováno v: Journal of Lipid Research, Vol 59, Iss 12, Pp 2403-2412 (2018)

We examined the association between pregnancy and life-course lipid trajectories. Linked data from the Nord-Trøndelag Health Study and the Medical Birth Registry of Norway yielded 19,987 parous and 1,625 nulliparous women. Using mixed-effects spline

Externí odkaz: https://doaj.org/article/661938bb6b714aa59247be550dde1b91

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