Antibody-dependent enhancement of toxicity of myotoxin II from Bothrops asper

Autor: Christoffer V. Sørensen, Julián Fernández, Anna Christina Adams, Helen H. K. Wildenauer, Sanne Schoffelen, Line Ledsgaard, Manuela B. Pucca, Michael Fiebig, Felipe A. Cerni, Tulika Tulika, Bjørn G. Voldborg, Aneesh Karatt-Vellatt, J. Preben Morth, Anne Ljungars, Lise M. Grav, Bruno Lomonte, Andreas H. Laustsen

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)

Abstract Improved therapies are needed against snakebite envenoming, which kills and permanently disables thousands of people each year. Recently developed neutralizing monoclonal antibodies against several snake toxins have shown promise in preclini

Externí odkaz: https://doaj.org/article/99301d927d1f464bb9fbaf12412f986c

A Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering

Autor: Johnny Arnsdorf, Chenguang Liang, Bjørn G. Voldborg, Benjamin P. Kellman, Bokan Bao, Anders Holmgaard Hansen, Nathan E. Lewis, James T. Sorrentino, Austin W. T. Chiang, Sanne Schoffelen

Publikováno v: Current Research in Biotechnology, Vol 2, Iss, Pp 22-36 (2020)
Liang, C, Chiang, A W T, Hansen, A H, Arnsdorf, J, Schoffelen, S, Sorrentino, J T, Kellman, B P, Bao, B, Voldborg, B G & Lewis, N E 2020, ' A Markov model of glycosylation elucidates isozyme specificity and glycosyltransferase interactions for glycoengineering ', Current Research in Biotechnology, vol. 2, pp. 22-36 . https://doi.org/10.1016/j.crbiot.2020.01.001
Curr Res Biotechnol

Glycosylated biopharmaceuticals are important in the global pharmaceutical market. Despite the importance of their glycan structures, our limited knowledge of the glycosylation machinery still hinders controllability of this critical quality attribut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8804b7be972f26057385ebe88f695122
http://www.sciencedirect.com/science/article/pii/S2590262820300010

CHOmics: A web-based tool for multi-omics data analysis and interactive visualization in CHO cell lines

Autor: Nathan E. Lewis, Dongdong Lin, Hima Yalamanchili, Christina S. Alves, Johnny Arnsdorf, Yizhou Zhou, Baohong Zhang, Tune Wulff, Xinmin Zhang, Sara Peterson Bjørn, Bjørn G. Voldborg, Joost Groot

Publikováno v: PLoS computational biology, vol 16, iss 12
PLoS Computational Biology
Lin, D, Yalamanchili, H B, Zhang, X, Lewis, N E, Alves, C S, Groot, J, Arnsdorf, J, Bjørn, S P, Wulff, T, Voldborg, B G, Zhou, Y & Zhang, B 2020, ' CHOmics : A web-based tool for multi-omics data analysis and interactive visualization in CHO cell lines ', PLOS Computational Biology, vol. 16, no. 12, e1008498 . https://doi.org/10.1371/journal.pcbi.1008498
PLoS Computational Biology, Vol 16, Iss 12, p e1008498 (2020)

Chinese hamster ovary (CHO) cell lines are widely used in industry for biological drug production. During cell culture development, considerable effort is invested to understand the factors that greatly impact cell growth, specific productivity and p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce535c630d3b5c1781f87633a7e721c
https://escholarship.org/uc/item/7kn8h9gx

In situ detection of protein interactions for recombinant therapeutic enzymes

Autor: Km Shams-Ud-Doha, Sara Petersen Bjørn, Mojtaba Samoudi, Alexandre Rosa Campos, Caressa M Robinson, Stefan Kol, Chih-Chung Kuo, Nathan E. Lewis, Linus Weiss, Bjørn G. Voldborg, Song-Min Schinn

Publikováno v: Biotechnology and bioengineering, vol 118, iss 2
Biotechnol Bioeng
Samoudi, M, Chung Kuo, C, Robinson, C M, Shams-Ud-Doha, K, Schinn, S-M, Kol, S, Weiss, L, Petersen Bjørn, S, Voldborg, B G, Rosa Campos, A & Lewis, N E 2021, ' In situ detection of protein interactions for recombinant therapeutic enzymes ', Biotechnology and Bioengineering, vol. 118, no. 2, pp. 890-904 . https://doi.org/10.1002/bit.27621

Despite their therapeutic potential, many protein drugs remain inaccessible to patients since they are difficult to secrete. Each recombinant protein has unique physicochemical properties and requires different machinery for proper folding, assembly,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8f0540ae6dd0a70f166b8a5419f2d2
https://doi.org/10.1101/2020.05.06.081885

High throughput generation of a resource of the human secretome in mammalian cells

Autor: Mathias Uhlén, Malin Westin, Andreas Hober, LanLan Xu, Björn Forsström, Bjørn G. Voldborg, Faranak Bidad, Siri Ekblad, Delaram Afshari, Lovisa Holmberg Schiavone, Hanna Tegel, Kalle von Feilitzen, Johan Rockberg, Jenny Ottosson Takanen, Fredrik Edfors, Sophia Hober, Anne-Sophie Svensson, Melanie Dannemeyer, Henric Enstedt, Magnus Lundqvist, Sinead Knight, Sven Göpel, Martin Zwahlen, Mona Moradi, Anna Berling, Rick Davies, Anna-Luisa Volk, Åsa Sivertsson, Lorenz M. Mayr, Sara Kanje

Publikováno v: Tegel, H, Dannemeyer, M, Kanje, S, Sivertsson, Å, Berling, A, Svensson, A S, Hober, A, Enstedt, H, Volk, A L, Lundqvist, M, Moradi, M, Afshari, D, Ekblad, S, Xu, L L, Westin, M, Bidad, F, Schiavone, L H, Davies, R, Mayr, L M, Knight, S, Göpel, S O, Voldborg, B G, Edfors, F, Forsström, B, von Feilitzen, K, Zwahlen, M, Rockberg, J, Takanen, J O, Uhlén, M & Hober, S 2020, ' High throughput generation of a resource of the human secretome in mammalian cells ', New Biotechnology, vol. 58, pp. 45-54 . https://doi.org/10.1016/j.nbt.2020.05.002

The proteins secreted by human tissues and blood cells, the secretome, are important both for the basic understanding of human biology and for identification of potential targets for future diagnosis and therapy. Here, a high-throughput mammalian cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac3c343bc5f3f5e43bfd18155a712f5c
https://pubmed.ncbi.nlm.nih.gov/32502629