Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Bjørn A. Nexø"'
Autor:
Bjørn A. Nexø, Bettina Hansen, Kari K. Nissen, Lisa Gundestrup, Thorkild Terkelsen, Palle Villesen, Shervin Bahrami, Thor Petersen, Finn S. Pedersen, Magdalena J. Laska
Publikováno v:
PLoS ONE, Vol 8, Iss 10 (2013)
Externí odkaz:
https://doaj.org/article/00bb2ee089ef42de84d598083c8c3fde
Autor:
Steffen Bank, Paal Skytt Andersen, Johan Burisch, Natalia Pedersen, Stine Roug, Julied Galsgaard, Stine Ydegaard Turino, Jacob Broder Brodersen, Shaista Rashid, Britt Kaiser Rasmussen, Sara Avlund, Thomas Bastholm Olesen, Hans Jürgen Hoffmann, Bjørn Andersen Nexø, Jacob Sode, Ulla Vogel, Vibeke Andersen
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145302 (2015)
BACKGROUND:The inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative colitis (UC), result from the combined effects of susceptibility genes and environmental factors. Previous studies have shown that polymorphisms in the Toll-like re
Externí odkaz:
https://doaj.org/article/6adca32d787e468397931117943be910
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53895 (2013)
DNA methylation and histone acetylation are epigenetic modifications that act as regulators of gene expression. DNA methylation is considered an important mechanism for silencing of retroelements in the mammalian genome. However, the methylation of h
Externí odkaz:
https://doaj.org/article/057c6c1084924bf1a4270ed528b2f5f6
Autor:
Bjørn A. Nexø
Publikováno v:
Nexø, B A 2018, ' A new theory on autoimmunity with reference to multiple sclerosis ', Immunologic Research, vol. 66, no. 3, pp. 336-339 . https://doi.org/10.1007/s12026-018-9003-x
Recent genetic evidence points towards endogenous retroviruses as playing a pivotal role in the causation of multiple sclerosis and possibly other autoimmune diseases. We discuss various ways in which this association could be brought about. Specific
Autor:
Bettina Hansen, Annette B Oturai, Hanne F Harbo, Elisabeth G Celius, Kari K Nissen, Magdalena J Laska, Helle B Søndergaard, Thor Petersen, Bjørn A Nexø
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26438 (2011)
We have previously described the occurrence of multiple sclerosis (MS) to be associated with human endogenous retroviruses, specifically the X-linked viral locus HERV-Fc1. The aim of this study was to investigate a possible association of the HERV-Fc
Externí odkaz:
https://doaj.org/article/7eb94400abe740a28d8e25108628b3f9
Autor:
Poul J. Bjerrum, Bjørn A. Nexø, Ulla Vogel, Janna Nissen, Hans Christian Wulf, Heddie Mejborn, Katja Howarth Madsen, Rikke Andersen, Elisabeth Wreford Andersen, Lone Banke Rasmussen, Gitte Ravn-Haren
Publikováno v:
The American Journal of Clinical Nutrition. 101:218-227
Background: Little is known about how the genetic variation in vitamin D modulating genes influences ultraviolet (UV)B‐induced 25-hydroxyvitamin D [25(OH)D] concentrations. In the Food with vitamin D (VitmaD) study, we showed that common genetic va
Publikováno v:
Journal of Multiple Sclerosis.
Background: We studied the cancer comorbidity of 18,212 Danish Multiple Sclerosis (MS) patients. Methods: Using data from the Danish National Patient Registry we identified all persons with a first-time MS diagnosis during 1980-2013. Cancer outcomes
Autor:
Hans Jürgen Hoffmann, Natalia Pedersen, Morten Frydenberg, Sara Avlund, Marianne Thomsen, Stine Roug, Jacob Broder Brodersen, Jacob Sode, Ulla Vogel, Vibeke Østergaard Thomsen, Vibeke Andersen, Shaista Rashid, Johan Burisch, Bjørn A. Nexø, Thomas Bastholm Olesen, Stine Ydegaard Turino, Steffen Bank, Britt Kaiser Rasmussen, Julie Galsgaard, Paal Skytt Andersen
Publikováno v:
Bank, S, Andersen, P S, Burisch, J, Pedersen, N, Roug, S, Galsgaard, J, Turino, S Y, Brodersen, J B, Rashid, S, Rasmussen, B K, Avlund, S, Olesen, T B, Hoffmann, H J, Thomsen, M K, Thomsen, V Ø, Frydenberg, M, Nexø, B A, Sode, J, Vogel, U & Andersen, V 2014, ' Associations between functional polymorphisms in the NFκB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease ', Pharmacogenomics Journal, vol. 14, pp. 526–534 . https://doi.org/10.1038/tpj.2014.19
Bank, S, Andersen, P S, Burisch, J, Pedersen, N, Roug, S, Galsgaard, J, Turino, S Y, Brodersen, J B, Rashid, S, Rasmussen, B K, Avlund, S, Olesen, T B, Hoffmann, H J, Thomsen, M K, Thomsen, V Ø, Frydenberg, M, Nexø, B A, Sode, J, Vogel, U & Andersen, V 2014, ' Associations between functional polymorphisms in the NFκB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease ', Pharmacogenomics Journal, pp. 526–534 . https://doi.org/10.1038/tpj.2014.19
Bank, S, Andersen, P S, Burisch, J, Pedersen, N, Roug, S, Galsgaard, J, Turino, S Y, Brodersen, J B, Rashid, S, Rasmussen, B K, Avlund, S, Olesen, T B, Hoffmann, H J, Thomsen, M K, Thomsen, V Ø, Frydenberg, M, Nexø, B A, Sode, J, Vogel, U & Andersen, V 2014, ' Associations between functional polymorphisms in the NFκB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease ', Pharmacogenomics Journal, pp. 526–534 . https://doi.org/10.1038/tpj.2014.19
Antitumor necrosis factor-α (TNF-α) is used for treatment of severe cases of inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). However, one-third of the patients do not respond to the treatment. Genetic
Genetic Evidence for Involvement of Human Endogenous Retrovirus Herv-Fc1 in the Pathogenesis of MPNs
Autor:
Mads Thomassen, Morten Orebo Holmström, Bjørn A. Nexø, Torben A Kruse, Katrine Lm Schmidt, Hans Carl Hasselbalch, Bettina Hansen, Magdalena Janina Laska, Christina Ellervik, Kasper Mønsted Pedersen, Vibe Skov, Tobias Wirenfeldt Klausen, Lasse Kjær
Publikováno v:
Skov, V, Schmidt, K L M, Pedersen, K M, Hansen, B, Klausen, T W, Kruse, T A, Thomassen, M, Kjaer, L, Ellervik, C, Holmstrom, M, Nexo, B, Hasselbalch, H C & Laska, M J 2018, ' Genetic Evidence for Involvement of Human Endogenous Retrovirus Herv-Fc1 in the Pathogenesis of MPNs ', Blood, vol. 132, no. Suppl. 1, 5488 . https://doi.org/10.1182/blood-2018-99-118080
Introduction: Human endogenous retroviruses (HERVs) are genomic sequences that result from ancestral germ-line infections by exogenous RVs and therefore are transmitted in a Mendelian fashion. Several lines of genetic evidence suggest the involvement
Publikováno v:
Ugeskrift for laeger. 178(24)
Retroviruses can be transmitted in two fundamentally different ways: 1) They can be horizontally transmitted as infectious virus, or 2) they can integrate in the germ line and be transmitted to offspring and the offsprings' offspring as DNA. The latt