Restriction genes for retroviruses influence the risk of multiple sclerosis.

Autor: Bjørn A Nexø, Bettina Hansen, Kari K Nissen, Lisa Gundestrup, Thorkild Terkelsen, Palle Villesen, Shervin Bahrami, Thor Petersen, Finn S Pedersen, Magdalena J Laska

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e74063 (2013)

We recently described that the autoimmune, central nervous system disease, multiple sclerosis (MS), is genetically associated with the human endogenous retroviral locus, HERV-Fc1, in Scandinavians. A number of dominant human genes encoding factors th

Externí odkaz: https://doaj.org/article/1328f62d57a147d4ab7f50b57ca1381a

Genetic association of multiple sclerosis with the marker rs391745 near the endogenous retroviral locus HERV-Fc1: analysis of disease subtypes.

Autor: Bettina Hansen, Annette B Oturai, Hanne F Harbo, Elisabeth G Celius, Kari K Nissen, Magdalena J Laska, Helle B Søndergaard, Thor Petersen, Bjørn A Nexø

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e26438 (2011)

We have previously described the occurrence of multiple sclerosis (MS) to be associated with human endogenous retroviruses, specifically the X-linked viral locus HERV-Fc1. The aim of this study was to investigate a possible association of the HERV-Fc

Externí odkaz: https://doaj.org/article/7eb94400abe740a28d8e25108628b3f9

Correction: Restriction Genes for Retroviruses Influence the Risk of Multiple Sclerosis.

Autor: Bjørn A. Nexø, Bettina Hansen, Kari K. Nissen, Lisa Gundestrup, Thorkild Terkelsen, Palle Villesen, Shervin Bahrami, Thor Petersen, Finn S. Pedersen, Magdalena J. Laska

Publikováno v: PLoS ONE, Vol 8, Iss 10 (2013)

Externí odkaz: https://doaj.org/article/00bb2ee089ef42de84d598083c8c3fde

Common variants in CYP2R1 and GC genes are both determinants of serum 25-hydroxyvitamin D concentrations after UVB irradiation and after consumption of vitamin D3–fortified bread and milk during winter in Denmark

Autor: Poul J. Bjerrum, Bjørn A. Nexø, Ulla Vogel, Janna Nissen, Hans Christian Wulf, Heddie Mejborn, Katja Howarth Madsen, Rikke Andersen, Elisabeth Wreford Andersen, Lone Banke Rasmussen, Gitte Ravn-Haren

Publikováno v: The American Journal of Clinical Nutrition. 101:218-227

Background: Little is known about how the genetic variation in vitamin D modulating genes influences ultraviolet (UV)B‐induced 25-hydroxyvitamin D [25(OH)D] concentrations. In the Food with vitamin D (VitmaD) study, we showed that common genetic va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8cdcb2c390598a13a8c6ec4c07a0bd17
https://doi.org/10.3945/ajcn.114.092148

Associations between functional polymorphisms in the NFκB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease

Autor: Hans Jürgen Hoffmann, Natalia Pedersen, Morten Frydenberg, Sara Avlund, Marianne Thomsen, Stine Roug, Jacob Broder Brodersen, Jacob Sode, Ulla Vogel, Vibeke Østergaard Thomsen, Vibeke Andersen, Shaista Rashid, Johan Burisch, Bjørn A. Nexø, Thomas Bastholm Olesen, Stine Ydegaard Turino, Steffen Bank, Britt Kaiser Rasmussen, Julie Galsgaard, Paal Skytt Andersen

Publikováno v: Bank, S, Andersen, P S, Burisch, J, Pedersen, N, Roug, S, Galsgaard, J, Turino, S Y, Brodersen, J B, Rashid, S, Rasmussen, B K, Avlund, S, Olesen, T B, Hoffmann, H J, Thomsen, M K, Thomsen, V Ø, Frydenberg, M, Nexø, B A, Sode, J, Vogel, U & Andersen, V 2014, ' Associations between functional polymorphisms in the NFκB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease ', Pharmacogenomics Journal, vol. 14, pp. 526–534 . https://doi.org/10.1038/tpj.2014.19
Bank, S, Andersen, P S, Burisch, J, Pedersen, N, Roug, S, Galsgaard, J, Turino, S Y, Brodersen, J B, Rashid, S, Rasmussen, B K, Avlund, S, Olesen, T B, Hoffmann, H J, Thomsen, M K, Thomsen, V Ø, Frydenberg, M, Nexø, B A, Sode, J, Vogel, U & Andersen, V 2014, ' Associations between functional polymorphisms in the NFκB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease ', Pharmacogenomics Journal, pp. 526–534 . https://doi.org/10.1038/tpj.2014.19

Antitumor necrosis factor-α (TNF-α) is used for treatment of severe cases of inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). However, one-third of the patients do not respond to the treatment. Genetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f54e2cd193ed1906cc53092aa41ee0
https://doi.org/10.1038/tpj.2014.19