Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Björn-Hergen Laabs"'
The combined effect of lifestyle factors and polygenic scores on age at onset in Parkinson’s disease
Autor:
Carolin Gabbert, Leonie Blöbaum, Theresa Lüth, Inke R. König, Amke Caliebe, Sebastian Sendel, Björn-Hergen Laabs, Christine Klein, Joanne Trinh
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract The objective of this study was to investigate the association between a Parkinson’s disease (PD)-specific polygenic score (PGS) and protective lifestyle factors on age at onset (AAO) in PD. We included data from 4367 patients with idiopat
Externí odkaz:
https://doaj.org/article/617082d44975422fabdcd48f3a0d9d2d
Autor:
Jenna Schellin, Alexander Neumann, Peter Schramm, Björn-Hergen Laabs, Jan Küchler, Hannes Schacht
Publikováno v:
Brain Circulation, Vol 9, Iss 3, Pp 178-184 (2023)
BACKGROUND: Use of iodine-containing contrast medium (CM) is obligatory for endovascular treatment (EVT) of cerebral aneurysms. After EVT, intracranial density increases (DIs) can be detected in cranial computed tomography (CT). Those DI can correspo
Externí odkaz:
https://doaj.org/article/af10fd0bb2fa422b91e9de7b0be1be01
Autor:
Frida Mandik, Yuliia Kanana, Jost Rody, Sophie Misera, Bernd Wilken, Björn-Hergen Laabs von Holt, Christine Klein, Melissa Vos
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Fatty acid hydroxylase-associated neurodegeneration (FAHN) is a rare disease that exhibits brain modifications and motor dysfunctions in early childhood. The condition is caused by a homozygous or compound heterozygous mutation in fatty acid 2 hydrox
Externí odkaz:
https://doaj.org/article/cbfa4ab939774d59ab40eef54e1c88bb
Autor:
Raphael Hirtz, Christine Hars, Roaa Naaresh, Björn-Hergen Laabs, Jochen Antel, Corinna Grasemann, Anke Hinney, Johannes Hebebrand, Triinu Peters
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
A fair number of epidemiological studies suggest that age at menarche (AAM) is associated with depression, but the reported effect sizes are small, and there is evidence of residual confounding. Moreover, previous Mendelian randomization (MR) studies
Externí odkaz:
https://doaj.org/article/d3820cfd463242db91a84061901a19f3
Autor:
Björn-Hergen Laabs, Christine Klein, Jelena Pozojevic, Aloysius Domingo, Norbert Brüggemann, Karen Grütz, Raymond L. Rosales, Roland Dominic Jamora, Gerard Saranza, Cid Czarina E. Diesta, Michael Wittig, Susen Schaake, Marija Dulovic-Mahlow, Jana Quismundo, Pia Otto, Patrick Acuna, Criscely Go, Nutan Sharma, Trisha Multhaupt-Buell, Ulrich Müller, Henrike Hanssen, Fabian Kilpert, Andre Franke, Arndt Rolfs, Peter Bauer, Valerija Dobričić, Katja Lohmann, Laurie J. Ozelius, Frank J. Kaiser, Inke R. König, Ana Westenberger
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Age at onset of X-linked dystonia-parkinsonism is 50% explained by the length of a repeat in an SVA insert. The authors perform a GWAS for genetic modifiers and discover three more loci, accounting for another 13% of variability in age at onset with
Externí odkaz:
https://doaj.org/article/11ebd21e7c7b492c804497da333f8fd9
Autor:
Triinu Peters, Jochen Antel, Roaa Naaresh, Björn-Hergen Laabs, Manuel Föcker, Nicola Albers, Judith Bühlmeier, Anke Hinney, Lars Libuda, Johannes Hebebrand
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Genetic correlations suggest a coexisting genetic predisposition to both low leptin levels and risk for anorexia nervosa (AN). To investigate the causality and direction of these associations, we performed bidirectional two-sample Mendelian randomiza
Externí odkaz:
https://doaj.org/article/d243cac8f8a44750ac3f59d0df6e8adf
Autor:
Triinu Peters, Lena Nüllig, Jochen Antel, Roaa Naaresh, Björn-Hergen Laabs, Lisa Tegeler, Chaima Amhaouach, Lars Libuda, Anke Hinney, Johannes Hebebrand
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Anthropometric traits and mental disorders or traits are known to be associated clinically and to show genetic overlap. We aimed to identify genetic variants with relevance for mental disorders/traits and either (i) body mass index (or obesity), (ii)
Externí odkaz:
https://doaj.org/article/da1dd1414cf14b319be87e872c7f064c
Autor:
Sebastian Koch, Björn-Hergen Laabs, Meike Kasten, Eva-Juliane Vollstedt, Jos Becktepe, Norbert Brüggemann, Andre Franke, Ulrike M. Krämer, Gregor Kuhlenbäumer, Wolfgang Lieb, Brit Mollenhauer, Miriam Neis, Claudia Trenkwalder, Eva Schäffer, Tatiana Usnich, Michael Wittig, Christine Klein, Inke R. König, Katja Lohmann, Michael Krawczak, Amke Caliebe
Publikováno v:
Genes, Vol 12, Iss 12, p 1859 (2021)
Idiopathic Parkinson’s disease (PD) is a complex multifactorial disorder caused by the interplay of both genetic and non-genetic risk factors. Polygenic risk scores (PRSs) are one way to aggregate the effects of a large number of genetic variants u
Externí odkaz:
https://doaj.org/article/197f6c8645424530b6d6ee2752a6c9c0
Autor:
Lars Libuda, Björn-Hergen Laabs, Christine Ludwig, Judith Bühlmeier, Jochen Antel, Anke Hinney, Roaa Naaresh, Manuel Föcker, Johannes Hebebrand, Inke R. König, Triinu Peters
Publikováno v:
Nutrients, Vol 11, Iss 5, p 1085 (2019)
While observational studies show an association between 25(OH)vitamin D concentrations and depressive symptoms, intervention studies, which examine the preventive effects of vitamin D supplementation on the development of depression, are lacking. To
Externí odkaz:
https://doaj.org/article/e75b69d0edc144cb896857a8a848981f
Autor:
Henrike Hanssen, Cid C. E. Diesta, Marcus Heldmann, Jackson Dy, Jeffrey Tantianpact, Julia Steinhardt, Rosanna Sauza, Hans T. S. Manalo, Andreas Sprenger, Charles Jourdan Reyes, Raphael Tuazon, Björn‐Hergen Laabs, Aloysius Domingo, Raymond L. Rosales, Christine Klein, Thomas F. Münte, Ana Westenberger, Jean Q. Oropilla, Norbert Brüggemann
Publikováno v:
Annals of Neurology. 93:999-1011