Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Björn Wallmark"'
Autor:
Björn Wallmark
Publikováno v:
Advances in Precision Medicine. 1
The article aimed to give a personal perspective on drug discovery and development. The author has worked both in Big Pharma as a scientist and manager and more recently also in start-up biotech companies. Drug companies have played a major important
Autor:
Karl Sewing, Susumo Okabe, Björn Wallmark, Basil I. Hirschowitz, Miguel J.M. Lewin, George Sachs, David J. Keeling, Michael E. Parsons
Publikováno v:
Digestive Diseases and Sciences. 40:3S-23S
The secretion of gastric acid is regulated both centrally and peripherally. The finding that H2-receptor antagonists are able to reduce or abolish acid secretion due to vagal, gastrinergic, and histaminergic stimulation shows that histamine plays a p
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1146:106-112
ATP-dependent proton transport in membrane vesicles prepared from the medullary bone of egg-laying hens, a source rich in osteoclasts, was characterized. Proton transport was abolished by bafilomycin A 1 (10 nM) and N -ethylmaleimide (50 μM), but no
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1065:261-268
The effects of omeprazole and bafilomycin on processes dependent on two different types of H(+)-translocating ATPases were compared. A H(+)-ATPase of the E1E2-type, the H+,K(+)-ATPase, was purified from gastric mucosa. Vacuolar type H(+)-ATPases were
Publikováno v:
Digestion. 47:39-44
The parietal cell acid pump inhibitor, omeprazole, has undergone numerous genotoxicity studies, the conclusions of which have all been negative. A recent report by Burlinson described a method which is claimed to measure unscheduled DNA synthesis (UD
Autor:
Frank Sundler, Björn Wallmark, Enar Carlsson, Hillevi Mattsson, Kjell Andersson, Rolf Håkanson, Inger Skånberg
Publikováno v:
Digestion. 45:181-188
In this study, the effect of ranitidine treatment on the activation and proliferation of rat gastric enterochromaffin-like (ECL) cells was investigated. The drug was given in a high dose in the food (1.7-1.8 g/kg/day) for 20 weeks. This dose correspo
Autor:
N. Havu, Frank Sundler, Wieslaw W. Pawlik, S J Konturek, M. Cieszkowski, G. Brunner, Andreas Pfeiffer, J. Chang, M.R. Moffatt, Władysław Bielański, RobertA. Goodlad, Hillevi Mattsson, J.L. Allen, Rolf Håkanson, Enar Carlsson, N.A. Wright, Simon A. Levin, Christian Hanack, Kjell Andersson, H. Mattsson, J. Tasler, A.J. Madgwick, Björn Wallmark, L. Ekman, Inger Skånberg
Publikováno v:
Digestion. 45:I-V
Autor:
Björn Wallmark
Publikováno v:
Von der Wahrnehmung zur Erkenntnis — From Perception to Understanding ISBN: 9783540240600
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::766fe7b8ccc5e2b989ceb79b2c8c7e25
https://doi.org/10.1007/3-540-27364-6_8
https://doi.org/10.1007/3-540-27364-6_8
Autor:
George Sachs, Björn Wallmark
Publikováno v:
Proton Pump Inhibitors ISBN: 9783034897778
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1407d214844e23bb3bed68e26c02ec9
https://doi.org/10.1007/978-3-0348-8795-3_2
https://doi.org/10.1007/978-3-0348-8795-3_2
Autor:
George Sachs, Björn Wallmark
Publikováno v:
Proton Pump Inhibitors ISBN: 9783034897778
For many years pharmacologists have utilized knowledge of the regulation of gastric acid secretion to discover and develop antisecretory agents. The first agents to emerge were the anticholinergic ones. These were associated with side effects, such a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c8a1ba335f92b57b65629ce5e1d0429
https://doi.org/10.1007/978-3-0348-8795-3_3
https://doi.org/10.1007/978-3-0348-8795-3_3