Výsledky vyhledávání - "Björn Viklund"

Akademický článek

Different patterns of clonal evolution among different sarcoma subtypes followed for up to 25 years

Autor: Jakob Hofvander, Björn Viklund, Anders Isaksson, Otte Brosjö, Fredrik Vult von Steyern, Pehr Rissler, Nils Mandahl, Fredrik Mertens

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)

Hofvander and colleagues compare the patterns of clonal evolution in different pathogenetic subgroups of sarcoma. They show that sarcomas driven by gene fusion or amplification display few additional changes over time, whereas sarcomas with complex k

Externí odkaz: https://doaj.org/article/05f473e7440244ce962db1231be2efa6

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Akademický článek

Scattered genomic amplification in dedifferentiated liposarcoma

Autor: Nils Mandahl, Linda Magnusson, Jenny Nilsson, Björn Viklund, Elsa Arbajian, Fredrik Vult von Steyern, Anders Isaksson, Fredrik Mertens

Publikováno v: Molecular Cytogenetics, Vol 10, Iss 1, Pp 1-10 (2017)

Abstract Background Atypical lipomatous tumor (ALT), well differentiated liposarcoma (WDLS) and dedifferentiated liposarcoma (DDLS) are cytogenetically characterized by near-diploid karyotypes with no or few other aberrations than supernumerary ring

Externí odkaz: https://doaj.org/article/74c03bfa97fb4b45a651147ff3f90cb4

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Figure S1 from Integrated Molecular Analysis of Undifferentiated Uterine Sarcomas Reveals Clinically Relevant Molecular Subtypes

Autor: Joseph W. Carlson, Anders Isaksson, Kaisa Lehti, Ben Davidson, Gunnar B. Kristensen, Anna Måsbäck, John K. Schoolmeester, Debra A. Bell, Lidia Moyano-Galceran, Jordi Gonzalez-Molina, Pádraic Corcoran, Nina Hollfelder, Cheng-Han Lee, Marisa R. Nucci, Tjalling Bosse, Mehran Ghaderi, Björn Viklund, Elin Hardell, Amrei Binzer-Panchal

Supplemental Figure 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb16d96fc5c06e0a2b85fb7df3533dc
https://doi.org/10.1158/1078-0432.22473591.v1

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Table S2 from Integrated Molecular Analysis of Undifferentiated Uterine Sarcomas Reveals Clinically Relevant Molecular Subtypes

Table S2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86b930a4e32b58c77a915b2e3bdaecf5
https://doi.org/10.1158/1078-0432.22473585

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Data from Integrated Molecular Analysis of Undifferentiated Uterine Sarcomas Reveals Clinically Relevant Molecular Subtypes

Purpose:Undifferentiated uterine sarcomas (UUS) are rare, extremely deadly, sarcomas with no effective treatment. The goal of this study was to identify novel intrinsic molecular UUS subtypes using integrated clinical, histopathologic, and molecular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b99268555f55b4fdf13b37e3671252b4
https://doi.org/10.1158/1078-0432.c.6528549

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Integrated Molecular Analysis of Undifferentiated Uterine Sarcomas Reveals Clinically Relevant Molecular Subtypes

Autor: Joseph W. Carlson, Debra A. Bell, Tjalling Bosse, Gunnar B. Kristensen, Cheng-Han Lee, Marisa R. Nucci, Jordi Gonzalez-Molina, Pádraic Corcoran, Anders Isaksson, Björn Viklund, Lidia Moyano-Galceran, Amrei Binzer-Panchal, John K. Schoolmeester, Kaisa Lehti, Elin Hardell, Ben Davidson, Anna Måsbäck, Mehran Ghaderi, Nina Hollfelder

Publikováno v: Clinical Cancer Research, 25(7), 2155-2165

Purpose: Undifferentiated uterine sarcomas (UUS) are rare, extremely deadly, sarcomas with no effective treatment. The goal of this study was to identify novel intrinsic molecular UUS subtypes using integrated clinical, histopathologic, and molecular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b02ceb9ed297166b23804bf5e48ce01
https://doi.org/10.1158/1078-0432.ccr-18-2792

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Genomic and transcriptomic features of dermatofibrosarcoma protuberans : Unusual chromosomal origin of the COL1A1-PDGFB fusion gene and synergistic effects of amplified regions in tumor development

Autor: Felix Haglund, Fredrik Mertens, Linda Magnusson, Jan Köster, Nils Mandahl, Björn Viklund, Anders Isaksson, Jakob Hofvander, Henrik C. F. Bauer, Elsa Arbajian

The dermatofibrosarcoma protuberans family of tumors (DPFT) comprises cutaneous soft tissue neoplasms associated with aberrant PDGFBR signaling, typically through a COL1A1-PDGFB fusion. The aim of the present study was to obtain a better understandin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ea65d3b30c36a123519fd71b981063e
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-407718

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Gains of Chromosome 1p and 15q are Associated with Poor Survival After Cytoreductive Surgery and HIPEC for Treating Colorectal Peritoneal Metastases

Autor: Malin Enblad, Wilhelm Graf, Anders Isaksson, Helgi Birgisson, Alexei Terman, Pascal Pucholt, Björn Viklund

Publikováno v: Annals of Surgical Oncology

Purpose Genetic alterations in colorectal peritoneal metastases (PM) are largely unknown. This study was designed to analyze whole-genome copy number alterations (CNA) in colorectal PM and to identify alterations associated with prognosis after cytor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dff872733d34cd557e7491358d25700
https://pubmed.ncbi.nlm.nih.gov/31620944

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Four evolutionary trajectories underlie genetic intratumoral variation in childhood cancer

Publikováno v: Nature genetics. 50(7)

A major challenge to personalized oncology is that driver mutations vary among cancer cells inhabiting the same tumor. Whether this reflects principally disparate patterns of Darwinian evolution in different tumor regions has remained unexplored1–5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc30e47f16600c2c4e3beadf92ee7253
https://pubmed.ncbi.nlm.nih.gov/29867221

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Scattered genomic amplification in dedifferentiated liposarcoma

Autor: Anders Isaksson, Linda Magnusson, Fredrik Mertens, Elsa Arbajian, Jenny Nilsson, Nils Mandahl, Björn Viklund, Fredrik Vult von Steyern

Publikováno v: Molecular Cytogenetics
Molecular Cytogenetics, Vol 10, Iss 1, Pp 1-10 (2017)

Background Atypical lipomatous tumor (ALT), well differentiated liposarcoma (WDLS) and dedifferentiated liposarcoma (DDLS) are cytogenetically characterized by near-diploid karyotypes with no or few other aberrations than supernumerary ring or giant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e68460f465c7d10c985025af1fbe52e
https://pubmed.ncbi.nlm.nih.gov/28652867

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