Efficacy and safety of adjunctive lacosamide in the treatment of primary generalised tonic-clonic seizures: a double-blind, randomised, placebo-controlled trial

Autor: David G, Vossler, Susanne, Knake, Terence J, O'Brien, Masako, Watanabe, Melissa, Brock, Björn, Steiniger-Brach, Paulette, Williams, Robert, Roebling, Jana, Zarubova

Publikováno v: Journal of Neurology, Neurosurgery, and Psychiatry

ObjectiveTo evaluate efficacy and safety of lacosamide (up to 12 mg/kg/day or 400 mg/day) as adjunctive treatment for uncontrolled primary generalised tonic-clonic seizures (PGTCS) in patients (≥4 years) with idiopathic generalised epilepsy (IGE).M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f84b13b8c2ba43be557d79392a7bfab5
https://doi.org/10.1136/jnnp-2020-323524

Effects of lacosamide and carbamazepine on lipids in a randomized trial

Autor: Svetlana Dimova, Ying Zhang, Marc De Backer, Scott Mintzer, Björn Steiniger-Brach, Robert Roebling, Daya Chellun

Publikováno v: Epilepsia. 61(12)

Objective The effects of anticonvulsants on lipids are the subject of considerable concern and investigation, but there are almost no data on this issue from randomized trials. We evaluated serum lipid profiles in adults with newly diagnosed epilepsy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d15c39dddd771c7a6b7fbed8e5b18001
https://pubmed.ncbi.nlm.nih.gov/33651399

Open-label Study with Nalmefene as Needed Use in Alcohol-Dependent Patients with Evidence of Elevated Liver Stiffness and/or Hepatic Steatosis

Autor: Doris Zhang, Mathias Luderer, Sebastian Mueller, Didier Meulien, Maiken Brix Schou, Björn Steiniger Brach

Publikováno v: Alcohol and Alcoholism.

Aims This open-label study in patients with alcohol dependence and evidence of elevated liver stiffness and/or hepatic steatosis was designed to explore the efficacy of nalmefene (18 mg) in reducing alcohol consumption and its subsequent effects on a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3675a3622657185ed7a7ed8730ad4093
https://doi.org/10.1093/alcalc/agz078

Nalmefene, Given as Needed, in the Routine Treatment of Patients with Alcohol Dependence: An Interventional, Open-Label Study in Primary Care

Autor: Didier Meulien, Maiken Brix Schou, Josef Großkopf, Doris Zhang, Björn Steiniger Brach, Edmund Stewart, Carlos Brotons, Philippe Castera

Publikováno v: European addiction research. 24(6)

Aims: This 12-week, open-label, primary care study (NCT02195817) evaluated the efficacy and safety of nalmefene, taken as needed, to reduce alcohol consumption in adults with a diagnosis of alcohol dependence and drinking at least at high drinking ri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be8937be3d38897b751d2fb1cba804be
https://pubmed.ncbi.nlm.nih.gov/30485854

Distinct Effects of Nalmefene on Dopamine Uptake Rates and Kappa Opioid Receptor Activity in the Nucleus Accumbens Following Chronic Intermittent Ethanol Exposure

Autor: Sara R. Jones, Jamie H. Rose, Björn Steiniger-Brach, Anushree N. Karkhanis

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 17, Iss 8, p 1216 (2016)
International Journal of Molecular Sciences; Volume 17; Issue 8; Pages: 1216

The development of pharmacotherapeutics that reduce relapse to alcohol drinking in patients with alcohol dependence is of considerable research interest. Preclinical data support a role for nucleus accumbens (NAc) κ opioid receptors (KOR) in chronic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d918ed62997acb8a777dcfcc760a681
http://europepmc.org/articles/PMC5000614