First-Line Venetoclax Combinations in Chronic Lymphocytic Leukemia

Autor: Barbara Eichhorst, Carsten U. Niemann, Arnon P. Kater, Moritz Fürstenau, Julia von Tresckow, Can Zhang, Sandra Robrecht, Michael Gregor, Gunnar Juliusson, Patrick Thornton, Philipp B. Staber, Tamar Tadmor, Vesa Lindström, Caspar da Cunha-Bang, Christof Schneider, Christian B. Poulsen, Thomas Illmer, Björn Schöttker, Thomas Nösslinger, Ann Janssens, Ilse Christiansen, Michael Baumann, Henrik Frederiksen, Marjolein van der Klift, Ulrich Jäger, Maria B.L. Leys, Mels Hoogendoorn, Kourosh Lotfi, Holger Hebart, Tobias Gaska, Harry Koene, Lisbeth Enggaard, Jereon Goede, Josien C. Regelink, Anouk Widmer, Florian Simon, Nisha De Silva, Anna-Maria Fink, Jasmin Bahlo, Kirsten Fischer, Clemens-Martin Wendtner, Karl A. Kreuzer, Matthias Ritgen, Monika Brüggemann, Eugen Tausch, Mark-David Levin, Marinus van Oers, Christian Geisler, Stephan Stilgenbauer, Michael Hallek

Publikováno v: Eichhorst, B, Niemann, C U, Kater, A P, Fürstenau, M, von Tresckow, J, Zhang, C, Robrecht, S, Gregor, M, Juliusson, G, Thornton, P, Staber, P B, Tadmor, T, Lindström, V, da Cunha-Bang, C, Schneider, C, Poulsen, C B, Illmer, T, Schöttker, B, Nösslinger, T, Janssens, A, Christiansen, I, Baumann, M, Frederiksen, H, van der Klift, M, Jäger, U, Leys, M B L, Hoogendoorn, M, Lotfi, K, Hebart, H, Gaska, T, Koene, H, Enggaard, L, Goede, J, Regelink, J C, Widmer, A, Simon, F, De Silva, N, Fink, A-M, Bahlo, J, Fischer, K, Wendtner, C-M, Kreuzer, K A, Ritgen, M, Brüggemann, M, Tausch, E, Levin, M-D, van Oers, M, Geisler, C, Stilgenbauer, S, Hallek, M, German CLL Study Group (GCLLSG), Haemato-Oncology Foundation for Adults in the Netherlands (HOVON), Nordic CLL Study Groups, Swiss Group for Clinical Cancer Research (SAKK), The Israeli CLL Association & Cancer Trials Ireland 2023, ' First-Line Venetoclax Combinations in Chronic Lymphocytic Leukemia ', The New England Journal of Medicine, vol. 388, no. 19, pp. 1739-1754 . https://doi.org/10.1056/NEJMoa2213093

BACKGROUNDRandomized trials of venetoclax plus anti-CD20 antibodies as first-line treatment in fit patients (i.e., those with a low burden of coexisting conditions) with advanced chronic lymphocytic leukemia (CLL) have been lacking.METHODSIn a phase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57065540dd32adf0cc1d031449d13807
https://vbn.aau.dk/da/publications/3cae35e7-c81b-42b3-8598-001ac74af83e

A Randomized Phase III Study of Venetoclax-Based Time-Limited Combination Treatments (RVe, GVe, GIVe) Vs Standard Chemoimmunotherapy (CIT: FCR/BR) in Frontline Chronic Lymphocytic Leukemia (CLL) of Fit Patients: First Co-Primary Endpoint Analysis of the International Intergroup GAIA (CLL13) Trial

Autor: Michael Gregor, Florian Simon, Philipp B. Staber, Anna-Maria Fink, Christof Schneider, Vesa Lindström, Matthias Ritgen, Mels Hoogendoorn, Caspar da Cunha-Bang, Tamar Tadmor, Thomas Illmer, Maria B.L. Leijs, Arnon P. Kater, Nisha De Silva, Clemens-Martin Wendtner, Can Zhang, Julia von Tresckow, Marinus H. J. van Oers, Stephan Stilgenbauer, Henrik Frederiksen, Carsten Utoft Niemann, Moritz Fürstenau, Eugen Tausch, Michael Baumann, Sandra Robrecht, Christian Bjørn Poulsen, Ann Janssens, Holger Hebart, Monika Brüggemann, Gunnar Juliusson, Karl-Anton Kreuzer, Thomas Noesslinger, Tobias Gaska, Marjolein van der Klift, Christian H. Geisler, Kourosh Lotfi, Ilse Christiansen, Barbara Eichhorst, Björn Schöttker, Harry R. Koene, Mark-David Levin, Patrick Thornton, Michael Hallek, Kirsten Fischer, Ulrich Jaeger

Publikováno v: Eichhorst, B, Niemann, C U, Kater, A P, Fürstenau, M, Von Tresckow, J, Zhang, C, Robrecht, S, Gregor, M, Juliusson, G, Thornton, P, Staber, P B, Tadmor, T, Lindström, V, da Cunha-Bang, C, Schneider, C, Poulsen, C B, Thomas Illmer, T, Schöttker, B, Janssens, A, Christiansen, I, Noesslinger, T, Baumann, M, van der Klift, M, Jaeger, U J, Frederiksen, H, B.L. Leijs, M, Hoogendoorn, M, Lotfi, K, Hebart, H, Gaska, T, Koene, H R, Simon, F, De Silva, N, Fink, A-M, Fischer, K, Clemens-Martin Wendtner, Kreuzer, K-A, Ritgen, M, Brüggemann, M B, Tausch, E, Levin, M-D, van Oers, M H J, Geisler, C H, Stilgenbauer, S & Hallek, M 2021, ' A Randomized Phase III Study of Venetoclax-Based Time-Limited Combination Treatments (RVe, GVe, GIVe) Vs Standard Chemoimmunotherapy (CIT: FCR/BR) in Frontline Chronic Lymphocytic Leukemia (CLL) of Fit Patients: First Co-Primary Endpoint Analysis of the International Intergroup GAIA (CLL13) Trial ', Blood, vol. 138, no. Supplement 1, pp. 71 . https://doi.org/10.1182/blood-2021-146161
Eichhorst, B, Niemann, C, Kater, A P, Fürstenau, M, Von Tresckow, J, Zhang, C, Robrecht, S, Gregor, M, Juliusson, G, Thornton, P, Staber, P B, Tadmor, T, Lindström, V, Da Cunha-Bang, C, Schneider, C, Poulsen, C B, Illmer, T, Schöttker, B, Janssens, A, Christiansen, I, Noesslinger, T, Baumann, M, van der Klift, M, Jaeger, U, Frederiksen, H, Leijs, M B L, Hoogendoorn, M, Lotfi, K, Hebart, H, Gaska, T, Koene, H R, Simon, F, De Silva, N, Fink, A-M, Fischer, K, Wendtner, C-M, Kreuzer, K-A, Ritgen, M, Brüggemann, M, Tausch, E, Levin, M-D, Van Oers, M H J, Geisler, C H, Stilgenbauer, S & Hallek, M 2021, ' A Randomized Phase III Study of Venetoclax-Based Time-Limited Combination Treatments (RVe, GVe, GIVe) Vs Standard Chemoimmunotherapy (CIT: FCR/BR) in Frontline Chronic Lymphocytic Leukemia (CLL) of Fit Patients: First Co-Primary Endpoint Analysis of the International Intergroup GAIA (CLL13) Trial ', Blood, vol. 138, no. Suppl. 1, 71 . https://doi.org/10.1182/blood-2021-146161

Background: For fit CLL patients (pts), continuous BTK inhibitor treatment is replacing CIT as standard of care in frontline setting, particularly in pts with unfavorable prognostic factors. The time limited combinations venetoclax plus obinutuzumab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46700f17dedbd3070657cd5923f53a3a
https://portal.findresearcher.sdu.dk/da/publications/fca2ae81-daf7-4cd6-8e83-f4a2a71437b8

Comparison of Tumor Lysis Syndrome (TLS) Risk Reduction and Incidence in Different Venetoclax-Based Combinations within the Randomized Phase 3 GAIA (CLL13) Trial

Autor: Eugen Tausch, Mark-David Levin, Barbara Eichhorst, Tamar Tadmor, Sandra Robrecht, Thomas Illmer, Michael Hallek, Nisha De Silva, Monika Brüggemann, Clemens-Martin Wendtner, Moritz Fürstenau, Julia Von Tresckow, Stephan Stilgenbauer, Caspar da Cunha-Bang, Björn Schöttker, Arnon P. Kater, Christof Schneider, Michael Gregor, Philipp B. Staber, Florian Simon, Anna-Maria Fink, Michael Baumann, Ilse Christiansen, Can Zhang, Kirsten Fischer, Christian Bjørn Poulsen, Carsten Utoft Niemann, Patrick Thornton, Ann Janssens, Matthias Ritgen, Marinus H. J. van Oers, Thomas Noesslinger, Christian H. Geisler

Publikováno v: Blood. 138:2639-2639

Background: In early studies of venetoclax (ven) in CLL, severe tumor lysis syndromes (TLS) were observed leading to the implementation of multiple safety measures including a 5-week ramp up schedule. Since then, studies have consistently reported lo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::459d71f49bcf7b0907ab810ddf6449c6
https://doi.org/10.1182/blood-2021-147790

Low Frequency of Enteric Infections by Salmonella, Shigella, Yersinia and Campylobacter in Patients with Acute Leukemia

Autor: C. Hahn, Ingo G.H. Schmidt-Wolf, Ernst Molitor, S Becker, Ulrich Mey, Björn Schöttker, Axel Glasmacher, Günter Marklein, Tilman Sauerbruch, Marcus Gorschlüter, Carsten Ziske

Publikováno v: Infection. 30:22-25

Background: Several authors found that isolation of Salmonella, Shigella, Yersinia and Campylobacter ssp. (SSYC) from stool cultures after the 3rd day of hospitalization is a rare event. The significance of enteric infections caused by these pathogen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc35246e50cedf57a8de0d35e341e3e5
https://doi.org/10.1007/s15010-002-1178-2

Increase in the immunostimulatory effect of dendritic cells by pulsing with serum derived from pancreatic and colorectal cancer patients

Autor: Tilman Sauerbruch, Sabine Renoth, Carsten Ziske, Christian Scheffold, Angela Märten, Frank Schakowski, Silvia Weineck, Björn Schöttker, Dietrich Klingmüller, Ingo G.H. Schmidt-Wolf, Alexander von Rücker, Peter Buttgereit

Publikováno v: International Journal of Colorectal Disease. 15:197-205

Both we and others have observed a relative resistance of solid tumor cells to immunological effector cells in vitro, which may be one reason for the clinical phenomenon of resistance of patients with pancreatic carcinoma or other solid tumors to imm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb7e00a5f62c330a1fd9cd9284a873b
https://doi.org/10.1007/s003840000243