Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Björn Niebel"'
Autor:
Kaori Mukai, Robert Cost, Xin Sheen Zhang, Emily Condiff, Joanne Cotton, Xiaohua Liu, Ekaterina Boudanova, Björn Niebel, Peter Piepenhagen, Xinming Cai, Anna Park, Qun Zhou
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
Recent developments in targeted protein degradation have provided great opportunities to eliminating extracellular protein targets using potential therapies with unique mechanisms of action and pharmacology. Among them, Lysosome-Targeting Chimeras (L
Externí odkaz:
https://doaj.org/article/1dec9122acc045ba9896b198c5b8e79d
Autor:
Uta Strübing, Victoria S. Halls, Christian S. Lentz, Michael Famulok, Björn Niebel, Günter Mayer, Achim Hoerauf, Jeffrey S. Hannam, Kenneth Pfarr
Publikováno v:
Chemistry & Biology; Vol 20
Chemistry & Biology
Chemistry & Biology
Summary Lymphatic filariasis and onchocerciasis are severe diseases caused by filarial worms and affect more than 150 million people worldwide. Endosymbiotic α-proteobacteria Wolbachia are essential for these parasites throughout their life cycle. U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f93f3ed0b3bdfa41c8a7a1da07e5f4
Autor:
Kenneth Pfarr, Günter Mayer, Monika Pofahl, Björn Niebel, Michael Famulok, Achim Hoerauf, Christian S. Lentz
Publikováno v:
Chemistry
Functional nucleic acids, such as aptamers and allosteric ribozymes, can sense their ligands specifically, thereby undergoing structural altera- tions that can be converted into a de- tectable signal. The direct coupling of molecular recognition to s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763f3493373f6548c38820b7e8ca3e17
https://doi.org/10.1002/chem.201001192
https://doi.org/10.1002/chem.201001192
Publikováno v:
Bioorganic & medicinal chemistry
Rho GTPases regulate the actin cytoskeleton and thereby control cell migration, cell morphology, cell motility, and other cellular functions. The gene product of the oncogene Tiam1 acts as a guanine nucleotide exchange factor (GEF) for the Rho GTPase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f004a26fa64ecb42fc997d8090b6977
https://hdl.handle.net/11858/00-001M-0000-0028-63EF-211858/00-001M-0000-0028-63F1-9
https://hdl.handle.net/11858/00-001M-0000-0028-63EF-211858/00-001M-0000-0028-63F1-9
Publikováno v:
Chembiochem : a European journal of chemical biology
The members of the large family of small-GTP-binding proteins (GTPases) function as molecular switches and are involved in regulation of a wide variety of cell processing events through signal cascades. Their molecular masses typically range between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f2295740877f66944a313cabd52fd6
https://pubmed.ncbi.nlm.nih.gov/22689339
https://pubmed.ncbi.nlm.nih.gov/22689339
Publikováno v:
Chemical Communications
We established a homogeneous luminescent oxygen channeling sensor for measuring activation states of small GTPases. The assay quantifies activated GTPases in cell lysates, can be applied to different GTPases, and can be used for multiplex screening.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a45d363f6278c6a2d07f82011efb3b5a
https://pubmed.ncbi.nlm.nih.gov/21625685
https://pubmed.ncbi.nlm.nih.gov/21625685