The aldo-keto reductase AKR1B7 coexpresses with renin without influencing renin production and secretion

Autor: Armin Kurtz, Katharina Machura, Franz Theuring, Björn Neubauer, Elina Iankilevitch

Publikováno v: American Journal of Physiology-Renal Physiology. 304:F578-F584

On the basis of evidence that within the adult kidney, the aldo-keto reductase AKR1B7 (aldo-keto reductase family 1, member 7, also known as mouse vas deferens protein, MVDP) is selectively expressed in renin-producing cells, we aimed to define a pos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485f086591648f7c355357fb3de7b8fd
https://doi.org/10.1152/ajprenal.00617.2012

The Connexin40 A96S Mutation Causes Renin-Dependent Hypertension

Autor: Armin Kurtz, Björn Neubauer, Katharina Machura, Lisa Kurtz, Charlotte Wagner, Klaus Willecke, Indra Lübkemeier, Frank Schweda, Radoslaw Dobrowolski

Publikováno v: Journal of the American Society of Nephrology. 22:1031-1040

Deletion of the gap-junction-forming protein connexin40 leads to renin-dependent hypertension in mice, but whether observed human variants in connexin40, such as A96S, promote hypertension is unknown. Here, we generated mice with the A96S variant in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2348c9e5c6d28a795e203248e7583d
https://doi.org/10.1681/asn.2010101047

Development of renin expression in the mouse kidney

Autor: Armin Kurtz, Katharina Machura, Charlotte Wagner, Björn Neubauer, Alexander W. Sauter

Publikováno v: Kidney International. 73(1):43-51

During metanephric kidney development, renin is expressed in the walls of larger intrarenal arteries, but is restricted to the terminal part of the preglomerular arterioles in the adult kidney. Our study describes the three-dimensional development of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79cd3e767396c7732dd7eb07ba2b4ac2

Endothelium-derived nitric oxide supports renin cell recruitment through the nitric oxide-sensitive guanylate cyclase pathway

Autor: Katharina Machura, Ramona Kettl, Björn Neubauer, Armin Kurtz, Maria Luisa S. Sequeira Lopez, Andreas Friebe

Publikováno v: Hypertension (Dallas, Tex. : 1979). 61(2)

Chronic challenge of renin–angiotensin causes recruitment of renin-producing cells in the kidney along the media layer of afferent arterioles and hypertrophy of cells in the juxtaglomerular apparatus. This study aimed to define the role of nitric o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62cd1bbc817ab136c752d92b7147fd48
https://pubmed.ncbi.nlm.nih.gov/23297373

cAMP target sequences enhCRE and CNRE sense low-salt intake to increase human renin gene expression in vivo

Autor: Stéphane Germain, Vladimir T. Todorov, Melanie Gerl, Sabine Harlander, Hayo Castrop, Michael Desch, Björn Neubauer

Publikováno v: Pflügers Archiv European Journal of Physiology
Pflügers Archiv European Journal of Physiology, 2011, 461 (5), pp.567--577. ⟨10.1007/s00424-011-0956-z⟩
Pflügers Archiv European Journal of Physiology, Springer Verlag, 2011, 461 (5), pp.567--577. ⟨10.1007/s00424-011-0956-z⟩

This study aimed to assess the role of cAMP target sequences enhancer cAMP response element (enhCRE) and cAMP and overlapping negative response element (CNRE) in the control of human renin gene (REN) in vivo. enhCRE and CNRE were silenced by mutation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b789ff19d7559a39ca7f44f4cd78f9
https://hal.science/hal-02142764