Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Björn Lamprecht"'
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0256521 (2021)
ObjectiveTo examine subgroup-specific treatment preferences and characteristics of patients with hemophilia A.MethodsBest-Worst Scaling (BWS) Case 3 (four attributes: application type; bleeding frequencies/year; inhibitor development risk; thromboemb
Externí odkaz:
https://doaj.org/article/80e25904062b4bd1b5641046edbea521
Autor:
Kathrin D. Wurster, Mariantonia Costanza, Stephan Kreher, Selina Glaser, Björn Lamprecht, Nikolai Schleussner, Ioannis Anagnostopoulos, Michael Hummel, Korinna Jöhrens, Harald Stein, Arturo Molina, Arjan Diepstra, Bernd Gillissen, Karl Köchert, Reiner Siebert, Olaf Merkel, Lukas Kenner, Martin Janz, Stephan Mathas
Publikováno v:
Cancers, Vol 13, Iss 19, p 5012 (2021)
In 50–60% of cases, systemic anaplastic large cell lymphoma (ALCL) is characterized by the t(2;5)(p23;q35) or one of its variants, considered to be causative for anaplastic lymphoma kinase (ALK)-positive (ALK+) ALCL. Key pathogenic events in ALK-ne
Externí odkaz:
https://doaj.org/article/3d34c87982f74b9b8b4321afb19142f3
Autor:
Stephan Kreher, Lukas Kenner, Kathrin D Wurster, Olaf Merkel, Nikolai Schleussner, Arjan Diepstra, Reiner Siebert, Bernd Gillissen, Ioannis Anagnostopoulos, Mariantonia Costanza, Selina Glaser, Björn Lamprecht, Arturo Molina, Karl Köchert, Harald Stein, Korinna Jöhrens, Michael Hummel, Martin Janz, Stephan Mathas
Publikováno v:
Cancers
Volume 13
Issue 19
Cancers, 13(19):5012. MDPI AG
Cancers, Vol 13, Iss 5012, p 5012 (2021)
Volume 13
Issue 19
Cancers, 13(19):5012. MDPI AG
Cancers, Vol 13, Iss 5012, p 5012 (2021)
In 50–60% of cases, systemic anaplastic large cell lymphoma (ALCL) is characterized by the t(2
5)(p23
q35) or one of its variants, considered to be causative for anaplastic lymphoma kinase (ALK)-positive (ALK+) ALCL. Key pathogenic events
5)(p23
q35) or one of its variants, considered to be causative for anaplastic lymphoma kinase (ALK)-positive (ALK+) ALCL. Key pathogenic events
Publikováno v:
Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research. 23(7)
Objective To assess patient preferences for benefits and risks in hemophilia A treatment. Methods A systematic literature search and pretest interviews were conducted to determine the most patient-relevant endpoints in terms of effects, risks, and ad
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0256521 (2021)
PLoS ONE
PLoS ONE
Objective To examine subgroup-specific treatment preferences and characteristics of patients with hemophilia A. Methods Best–Worst Scaling (BWS) Case 3 (four attributes: application type; bleeding frequencies/year; inhibitor development risk; throm
Autor:
Burkhard Wiesner, Joachim Behlke, David Schwefel, Stephan Mathas, Oliver Daumke, Björn Lamprecht, Jenny Eichhorst, Eva Rosenbaum, B. Sivanandam Arasu, Karl Köchert, Oliver Rocks, Stephen Marino
Publikováno v:
Structure. 21(4):550-559
SummaryGTPases of immunity-associated proteins (GIMAPs) are regulators of lymphocyte survival and homeostasis. We previously determined the structural basis of GTP-dependent GIMAP2 scaffold formation on lipid droplets. To understand how its GTP hydro
Autor:
Wolfram Sterry, Björn Lamprecht, Markus Möbs, Stephan Mathas, Stephan Kreher, Chalid Assaf, Martin Janz, Bernd Dörken
Publikováno v:
British Journal of Dermatology. 167:240-246
Summary Background Primary cutaneous T-cell lymphomas (CTCLs) are a heterogeneous group with Sezary syndrome (SS) as one of the most aggressive variants. Recently, we identified a loss of E2A as a recurrent event in SS, which enhanced proliferation v
Autor:
Karl Köchert, Stephan Mathas, Michael Hummel, Ioannis Anagnostopoulos, Björn Lamprecht, Claus-Detlev Klemke, Reinhard Ullmann, Evelin Schröck, Harald Stein, Stephan Kreher, Markus Möbs, Chalid Assaf, Wolfram Sterry, Anne Steininger, Julia Richter, Martin Janz, Bernd Dörken, Marc Beyer
Publikováno v:
The Journal of Experimental Medicine
Loss of E2A, observed in more than 70% of patients with Sézary syndrome, which is a subtype of T cell lymphoma, results in altered expression of genes potentially relevant to oncogenesis.
The transcription factor E2A is essential for lymphocyte
The transcription factor E2A is essential for lymphocyte
Publikováno v:
Cell Cycle. 9:4276-4281
Recent data demonstrated that the raberrant activity of endogenous repetitive elements of the DNA in humans can drive the expression of proto-oncogenes. This article summarizes these results and gives an outlook on the impact of these findings on the
Autor:
Martin Janz, Ralph Stadhouders, Rachael Barlow, Maciej Giefing, Dido Lenze, Raman Kumar, Korden Walter, Eric Soler, Julia Richter, Kathrin D. Wurster, Karl Köchert, Reiner Siebert, Constanze Bonifer, Michael Hummel, Ioannis Anagnostopoulos, Bernd Dörken, Korinna Jöhrens, Björn Lamprecht, Michael F Harte, Peter N. Cockerill, Stephan Mathas, Stephan Kreher, David F. Callen, Mohamed Amine Bouhlel, Harald Stein
Publikováno v:
Nature Medicine, 16(5), 571-579. Nature Publishing Group
Mammalian genomes contain many repetitive elements, including long terminal repeats (LTRs), which have long been suspected to have a role in tumorigenesis. Here we present evidence that aberrant LTR activation contributes to lineage-inappropriate gen