Zobrazeno 1 - 10
of 212
pro vyhledávání: '"Björn H. Falkenburger"'
Autor:
Tom Hähnel, Tamara Raschka, Stefano Sapienza, Jochen Klucken, Enrico Glaab, Jean-Christophe Corvol, Björn H. Falkenburger, Holger Fröhlich
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract The progression of Parkinson’s disease (PD) is heterogeneous across patients, affecting counseling and inflating the number of patients needed to test potential neuroprotective treatments. Moreover, disease subtypes might require different
Externí odkaz:
https://doaj.org/article/a81e2975ba6a421aae414dee1e0287ca
Autor:
Anika Frank, Jonas Bendig, Nils Schnalke, Lisa Klingelhoefer, Heinz Reichmann, Katja Akgün, Tjalf Ziemssen, Björn H. Falkenburger
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-7 (2024)
Abstract Different stages of Parkinson’s disease (PD) are defined by clinical criteria, while late-stage PD is marked by the onset of morbidity milestones and rapid clinical deterioration. Based on neuropathological evidence, degeneration in the do
Externí odkaz:
https://doaj.org/article/649afe966c7d4e60b3f2218e7a639097
Autor:
Stefan Bräuer, Marcello Rossi, Johann Sajapin, Thomas Henle, Thomas Gasser, Piero Parchi, Kathrin Brockmann, Björn H. Falkenburger
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-9 (2023)
Abstract The alpha-synuclein (aSyn) seed amplification assay (SAA) can identify aSyn aggregates as indicator for Lewy body pathology in biomaterials of living patients and help in diagnosing Parkinson´s disease and dementia syndromes. Our objective
Externí odkaz:
https://doaj.org/article/179f7c1706ea4353babb1a925f2dfaeb
Autor:
Lennart Höfs, David Geißler-Lösch, Kristof M. Wunderlich, Eva M. Szegö, Chris Van den Haute, Veerle Baekelandt, Wolfgang Hoyer, Björn H. Falkenburger
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 756 (2024)
Aggregation of the protein α-Synuclein (αSyn) is a hallmark of Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple systems atrophy, and alleviating the extent of αSyn pathology is an attractive strategy against neurodegenerati
Externí odkaz:
https://doaj.org/article/56e384f27b224c169fcf2c4f39ceedc3
Autor:
Anika Frank, Jonas Bendig, Iñaki Schniewind, Witold H. Polanski, Stephan B. Sobottka, Heinz Reichmann, Katja Akgün, Tjalf Ziemssen, Lisa Klingelhoefer, Björn H. Falkenburger
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-5 (2022)
Abstract Deep brain stimulation (DBS) is a potent symptomatic therapy for Parkinson’s disease, but it is debated whether it causes or prevents neurodegeneration. We used serum neurofilament light chain (NFL) as a reporter for neuronal damage and fo
Externí odkaz:
https://doaj.org/article/c89caf365ecf45e391c573c669ccd009
Autor:
Maike R. Pollmanns, Judith Beer, Ines Rosignol, Natalia Rodriguez-Muela, Björn H. Falkenburger, Elisabeth Dinter
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Background: Protein aggregates are degraded via the autophagy-lysosome pathway and alterations in the lysosomal system leading to the accumulation of pathogenic proteins, including aggregates of α-synuclein in Parkinson’s disease (PD). The importa
Externí odkaz:
https://doaj.org/article/b4e37ee157ba41abb42096ec666f1feb
Autor:
Elisabeth Dinter, Theodora Saridaki, Leonie Diederichs, Heinz Reichmann, Björn H. Falkenburger
Publikováno v:
Translational Neurodegeneration, Vol 9, Iss 1, Pp 1-11 (2020)
Abstract Parkinson’s disease (PD) is diagnosed when patients exhibit bradykinesia with tremor and/or rigidity, and when these symptoms respond to dopaminergic medications. Yet in the last years there was a greater recognition of additional aspects
Externí odkaz:
https://doaj.org/article/344ea47ebac047bf8cda54261c922b4b
Autor:
Yuemin Tian, Patricia Korn, Priyanka Tripathi, Daniel Komnig, Dominik Wiemuth, Azadeh Nikouee, Arno Classen, Carsten Bolm, Björn H. Falkenburger, Bernhard Lüscher, Stefan Gründer
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-14 (2020)
Abstract Background ADP-ribosylation is a ubiquitous post-translational modification that involves both mono- and poly-ADP-ribosylation. ARTD10, also known as PARP10, mediates mono-ADP-ribosylation (MARylation) of substrate proteins. A previous scree
Externí odkaz:
https://doaj.org/article/d12516ddf36f48518665570f180203b6
Autor:
Éva M. Szegő, Fabian Boß, Daniel Komnig, Charlott Gärtner, Lennart Höfs, Hamed Shaykhalishahi, Michael M. Wördehoff, Theodora Saridaki, Jörg B. Schulz, Wolfgang Hoyer, Björn H. Falkenburger
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Reducing α-synuclein pathology constitutes a plausible strategy against Parkinson’s disease. As we recently demonstrated, the β-wrapin protein AS69 binds an N-terminal region in monomeric α-synuclein, interferes with fibril nucleation, and reduc
Externí odkaz:
https://doaj.org/article/4afc3502a31946d28cb7ee107aa29503
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Acid-sensing ion channels (ASICs) are proton-gated Na+ channels. They contribute to synaptic transmission, neuronal differentiation and neurodegeneration. ASICs have been mainly characterized in neurons from mice or rats and our knowledge of their pr
Externí odkaz:
https://doaj.org/article/b083241d9ca0406483c785dfe489aea6