Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Björn, Schneider"'
Autor:
Thomas Freitag, Philipp Kaps, Justus Ramtke, Sarah Bertels, Emily Zunke, Björn Schneider, Anne-Sophie Becker, Dirk Koczan, Daniel Dubinski, Thomas M. Freiman, Felix Wittig, Burkhard Hinz, Mike-Andrew Westhoff, Hannah Strobel, Franziska Meiners, Daniel Wolter, Nadja Engel, Sascha Troschke-Meurer, Wendy Bergmann-Ewert, Susanne Staehlke, Annabell Wolff, Florian Gessler, Christian Junghanss, Claudia Maletzki
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-17 (2024)
Abstract Here, we show that combined use of the EZH2 inhibitor GSK126 and the CDK4/6 inhibitor abemaciclib synergistically enhances antitumoral effects in preclinical GBM models. Dual blockade led to HIF1α upregulation and CalR translocation, accomp
Externí odkaz:
https://doaj.org/article/48c31a82a0d54c5ea79c6f99d70e3d61
Autor:
Falko Lange, Richard Gade, Anne Einsle, Katrin Porath, Gesine Reichart, Claudia Maletzki, Björn Schneider, Christian Henker, Daniel Dubinski, Michael Linnebacher, Rüdiger Köhling, Thomas M. Freiman, Timo Kirschstein
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundThe differentiation of high-grade glioma and brain tumors of an extracranial origin is eminent for the decision on subsequent treatment regimens. While in high-grade glioma, a surgical resection of the tumor mass is a fundamental part of cu
Externí odkaz:
https://doaj.org/article/dbe6cf8eeb524090a81b93767e6a50e6
Autor:
Charlotte Linke, Thomas Freitag, Christin Riess, Jana Vanessa Scheffler, Katharina del Moral, Nina Schoenwaelder, Tomas Fiedler, Adina Fiebig, Philipp Kaps, Daniel Dubinski, Björn Schneider, Wendy Bergmann, Carl Friedrich Classen, Claudia Maletzki
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-18 (2023)
Abstract Background Arginine auxotrophy constitutes a shortcoming for ~ 30% of glioblastoma multiforme (GBM). Indeed, arginine-depleting therapy using arginine deiminase from Streptococcus pyogenes (SpyADI) has proven activity against GBM in preclini
Externí odkaz:
https://doaj.org/article/b688d5f6f21b43c69fa8ffaf7d1c4143
Autor:
Daniel Strüder, Theresa Momper, Nina Irmscher, Mareike Krause, Jan Liese, Sebastian Schraven, Annette Zimpfer, Sarah Zonnur, Ann-Sophie Burmeister, Björn Schneider, Bernhard Frerich, Robert Mlynski, Christina Große-Thie, Christian Junghanss, Claudia Maletzki
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-13 (2021)
Abstract Background Head and neck squamous cell carcinoma (HNSCC) is heterogeneous in etiology, phenotype and biology. Patient-derived xenografts (PDX) maintain morphology and molecular profiling of the original tumors and have become a standard “A
Externí odkaz:
https://doaj.org/article/d6e3eb7cd6c84d1aaa3e66ee76b4a178
Autor:
Christin Riess, Dirk Koczan, Björn Schneider, Charlotte Linke, Katharina del Moral, Carl Friedrich Classen, Claudia Maletzki
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-15 (2021)
Abstract Current therapeutic approaches have met limited clinical success for glioblastoma multiforme (GBM). Since GBM harbors genomic alterations in cyclin-dependent kinases (CDKs), targeting these structures with specific inhibitors (CDKis) is prom
Externí odkaz:
https://doaj.org/article/68fa0d1afbb74b2487585beff34bf5af
Autor:
Christin Riess, Björn Schneider, Hanna Kehnscherper, Julia Gesche, Nina Irmscher, Fatemeh Shokraie, Carl Friedrich Classen, Elisa Wirthgen, Grazyna Domanska, Annette Zimpfer, Daniel Strüder, Christian Junghanss, Claudia Maletzki
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO2) are the key enzymes of tryptophan (TRP) metabolism in the kynurenine pathway (KP). Both enzymes function as indicators of immunosuppression and poor survival in cancer patients.
Externí odkaz:
https://doaj.org/article/84a6ad70899d454bb54e3837a71f103e
Autor:
Annette Zimpfer, Said Kdimati, Melanie Mosig, Henrik Rudolf, Heike Zettl, Andreas Erbersdobler, Oliver W. Hakenberg, Matthias Maruschke, Björn Schneider
Publikováno v:
Cancers; Volume 15; Issue 9; Pages: 2414
Upper tract urothelial carcinomas (UTUCs) occur in about 5–10% of all urothelial carcinomas and are frequently discovered in high-stage disease. We aimed to evaluate human epidermal growth factor receptor 2 (ERBB2) protein expression immunohistoche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090ada36be234813e24b9ac763ca63dd
Autor:
Björn Schneider, Doreen William, Nora Lamp, Annette Zimpfer, Christian Henker, Carl Friedrich Classen, Andreas Erbersdobler
Publikováno v:
Molecular and Cellular Biochemistry. 477:2297-2307
Glioblastoma (GBM) is one of the most frequent primary brain tumors. Limited therapeutic options and high recurrency rates lead to a dismal prognosis. One frequent, putative driver mutation is the genomic amplification of the oncogenic receptor tyros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f908aaba8c06781a5978f1f68e1da04
https://doi.org/10.1007/s11010-022-04435-y
https://doi.org/10.1007/s11010-022-04435-y
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0191511 (2018)
Glioblastoma multiforme (GBM) is a highly heterogeneous and aggressive brain tumor with a dismal prognosis. Development of resistance towards cytostatic drugs like the GBM standard drug temozolomide is a severe problem in GBM treatment. One potential
Externí odkaz:
https://doaj.org/article/284410bcc079432f9a855fd7b31ffe02
Publikováno v:
Molecular Medicine Reports. 27
Glioblastoma is one of the most frequent primary brain tumors with a poor prognosis. Nevertheless, some patients show a prolonged survival. The aim of the present study was to compare the expression profiles of tumor derived microRNA (miR) of long‑
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd13cfe15c5a97c1846d5db16ec877f8
https://doi.org/10.3892/mmr.2022.12895
https://doi.org/10.3892/mmr.2022.12895