Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Björn, Reinius"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Single-cell RNA-sequencing (scRNAseq) is revolutionizing biomedicine, propelled by advances in methodology, ease of use, and cost reduction of library preparation. Over the past decade, there have been remarkable technical improvements in mo
Externí odkaz:
https://doaj.org/article/f9edc62b96b94a309aca55398cd1f6bf
Autor:
Ioanna Smyrlaki, Ferenc Fördős, Iris Rocamonde-Lago, Yang Wang, Boxuan Shen, Antonio Lentini, Vincent C. Luca, Björn Reinius, Ana I. Teixeira, Björn Högberg
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The Notch signaling pathway has fundamental roles in embryonic development and in the nervous system. The current model of receptor activation involves initiation via a force-induced conformational change. Here, we define conditions that rev
Externí odkaz:
https://doaj.org/article/e0cd4cdde23c495385b0467afe5fe727
Autor:
Antonio Lentini, Huaitao Cheng, J. C. Noble, Natali Papanicolaou, Christos Coucoravas, Nathanael Andrews, Qiaolin Deng, Martin Enge, Björn Reinius
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The concerted dynamics of X-chromosome upregulation and X-chromosome inactivation, which collectively balance X-chromosome expression, are not well understood. Using allelic single-cell genomics, the authors characterize the dynamics of X-chromosome
Externí odkaz:
https://doaj.org/article/949ff02b1814415dbfce7936d7db6c4c
Autor:
Alisa Alekseenko, Donal Barrett, Yerma Pareja-Sanchez, Rebecca J. Howard, Emilia Strandback, Henry Ampah-Korsah, Urška Rovšnik, Silvia Zuniga-Veliz, Alexander Klenov, Jayshna Malloo, Shenglong Ye, Xiyang Liu, Björn Reinius, Simon J. Elsässer, Tomas Nyman, Gustaf Sandh, Xiushan Yin, Vicent Pelechano
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract RT-LAMP detection of SARS-CoV-2 has been shown to be a valuable approach to scale up COVID-19 diagnostics and thus contribute to limiting the spread of the disease. Here we present the optimization of highly cost-effective in-house produced
Externí odkaz:
https://doaj.org/article/1f27a366d4e94aed943f786f5264f7a0
Autor:
Ioanna Smyrlaki, Martin Ekman, Antonio Lentini, Nuno Rufino de Sousa, Natali Papanicolaou, Martin Vondracek, Johan Aarum, Hamzah Safari, Shaman Muradrasoli, Antonio Gigliotti Rothfuchs, Jan Albert, Björn Högberg, Björn Reinius
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
SARS-CoV-2 infection is widely diagnosed by RT-PCR, but RNA extraction is a bottleneck for fast and cheap diagnosis. Here, the authors develop protocols to perform RT-PCR directly on heat-inactivated subject samples or samples lysed with readily avai
Externí odkaz:
https://doaj.org/article/1fdca452b94243fe9b1c96011a64ebaf
Transcriptional bursts explain autosomal random monoallelic expression and affect allelic imbalance.
Autor:
Anton J M Larsson, Christoph Ziegenhain, Michael Hagemann-Jensen, Björn Reinius, Tina Jacob, Tim Dalessandri, Gert-Jan Hendriks, Maria Kasper, Rickard Sandberg
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 3, p e1008772 (2021)
Transcriptional bursts render substantial biological noise in cellular transcriptomes. Here, we investigated the theoretical extent of allelic expression resulting from transcriptional bursting and how it compared to the amount biallelic, monoallelic
Externí odkaz:
https://doaj.org/article/34266d00cadf45e0b0c24c11ceee3b37
Autor:
Ábel Vértesy, Wibowo Arindrarto, Matthias S. Roost, Björn Reinius, Vanessa Torrens-Juaneda, Monika Bialecka, Ioannis Moustakas, Yavuz Ariyurek, Ewart Kuijk, Hailiang Mei, Rickard Sandberg, Alexander van Oudenaarden, Susana M. Chuva de Sousa Lopes
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
In mammalian female germ cells, parent-specific epigenetic marks are erased and the X chromosome reactivated before entry into meiosis. Here, by combining parental haplotype reconstruction with single-cell transcriptomics of human female embryonic ge
Externí odkaz:
https://doaj.org/article/2b4ac2ed364b4f8a93b6e4cd64a219b7
Autor:
Shangli Cheng, Yu Pei, Liqun He, Guangdun Peng, Björn Reinius, Patrick P.L. Tam, Naihe Jing, Qiaolin Deng
Publikováno v:
Cell Reports, Vol 26, Iss 10, Pp 2593-2607.e3 (2019)
Summary: Following implantation, the epiblast (EPI) cells transit from the naive to primed pluripotency, accompanied by dynamic changes in X chromosome activity in females. To investigate the molecular attributes of this process, we performed single-
Externí odkaz:
https://doaj.org/article/813d1ac16fe24908bed40e44175173ba
Autor:
Per Johnsson, Christoph Ziegenhain, Leonard Hartmanis, Gert-Jan Hendriks, Michael Hagemann-Jensen, Björn Reinius, Rickard Sandberg
Publikováno v:
Nature Genetics. 54:306-317
An increasing number of long noncoding RNAs (lncRNAs) have experimentally confirmed functions, yet little is known about their transcriptional dynamics and it is challenging to determine their regulatory effects. Here, we used allele-sensitive single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82d0e85c38be8c164fc65b7791342260
https://doi.org/10.1038/s41588-022-01014-1
https://doi.org/10.1038/s41588-022-01014-1
Autor:
Tanmoy Mondal, Santhilal Subhash, Roshan Vaid, Stefan Enroth, Sireesha Uday, Björn Reinius, Sanhita Mitra, Arif Mohammed, Alva Rani James, Emily Hoberg, Aristidis Moustakas, Ulf Gyllensten, Steven J. M. Jones, Claes M. Gustafsson, Andrew H. Sims, Fredrik Westerlund, Eduardo Gorab, Chandrasekhar Kanduri
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-2 (2019)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/b64ed72c1fe546cd9b656143e01763f1