Zobrazeno 1 - 10
of 191
pro vyhledávání: '"Björn, Heindryckx"'
Autor:
Paraskevi Athanasouli, Martina Balli, Anchel De Jaime-Soguero, Annekatrien Boel, Sofia Papanikolaou, Bernard K. van der Veer, Adrian Janiszewski, Tijs Vanhessche, Annick Francis, Youssef El Laithy, Antonio Lo Nigro, Francesco Aulicino, Kian Peng Koh, Vincent Pasque, Maria Pia Cosma, Catherine Verfaillie, An Zwijsen, Björn Heindryckx, Christoforos Nikolaou, Frederic Lluis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Signal transduction and gene expression regulation via downstream transcription factors shape the early mammalian embryo. Here the authors show that Wnt/TCF7L1 transcriptional repressive activity is required for primitive endoderm lineage formation.
Externí odkaz:
https://doaj.org/article/8c6090935fbd461d86225955994338e9
Autor:
Maya Sen, Dylan Mooijman, Alex Chialastri, Jean-Charles Boisset, Mina Popovic, Björn Heindryckx, Susana M. Chuva de Sousa Lopes, Siddharth S. Dey, Alexander van Oudenaarden
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Erasure of DNA methylation from the parental genomes is critical to reset the methylome of differentiated gametes to pluripotent cells in the blastocyst. Here, the authors present a high-throughput single-cell method that enables strand-specific quan
Externí odkaz:
https://doaj.org/article/22a65134bcec4622ac372fd22140fe71
Autor:
Bieke BEKAERT, Annekatrien BOEL, Lisa DE WITTE, Mina POPOVIC, Panagiotis STAMATIADIS, Gwenny COSEMANS, Lise TORDEURS, Susana MARINA CHUVA DE SOUSA LOPES, Petra DE SUTTER, Björn MENTEN, Dominic STOOP, Paul COUCKE, Björn HEINDRYCKX
Publikováno v:
Fertility & Reproduction, Vol 04, Iss 03n04, Pp 89-89 (2022)
Human germline gene correction by CRISPR/Cas9 holds great promise to eliminate transmission of genetic mutations. Recent studies have however made troublesome observations of mosaicism (the occurrence of multiple genetic events in one embryo) and los
Externí odkaz:
https://doaj.org/article/bf1c12c678654bb397d64a33a8373934
Autor:
Antonia Christodoulaki, Annekatrien Boel, Maoxing Tang, Chloë De Roo, Dominic Stoop, Björn Heindryckx
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Diminished ovarian reserve (DOR) is associated with a reduced quantity and quality of the retrieved oocytes, usually leading to poor reproductive outcomes which remain a great challenge for assisted reproduction technology (ART). Women with DOR often
Externí odkaz:
https://doaj.org/article/423211a96efe4826b5e0e36efcca6f85
Autor:
Xiaoyuan Lin, Krishna Chaitanya Pavani, Katrien Smits, Dieter Deforce, Björn Heindryckx, Ann Van Soom, Luc Peelman
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
In a previous study, we found miR-10b to be more abundant in a conditioned culture medium of degenerate embryos compared to that of blastocysts. Here, we show that miR-10b mimics added to the culture medium can be taken up by embryos. This uptake res
Externí odkaz:
https://doaj.org/article/aa2394e27ca84b7aa8b2bca084a2fa81
Sex-Specific Isolation and Propagation of Human Premeiotic Fetal Germ Cells and Germ Cell-Like Cells
Autor:
Swati Mishra, Jasin Taelman, Yolanda W. Chang, Annekatrien Boel, Petra De Sutter, Björn Heindryckx, Susana M. Chuva De Sousa Lopes
Publikováno v:
Cells, Vol 10, Iss 5, p 1214 (2021)
The second trimester of human development is marked by asynchronous gonadal development hampering the isolation of homogenous populations of early and late fetal germ cells (FGCs). We evaluated the feasibility of using surface markers TNAP, PDPN, EPC
Externí odkaz:
https://doaj.org/article/2b5bf5efc0c04cc9888a73fd17c2316c
Autor:
Jitesh Neupane, Sabitri Ghimire, Mado Vandewoestyne, Yuechao Lu, Jan Gerris, Rudy Van Coster, Tom Deroo, Dieter Deforce, Stijn Vansteelandt, Petra De Sutter, Björn Heindryckx
Publikováno v:
Cell Reports, Vol 13, Iss 7, Pp 1304-1309 (2015)
Variation in the level of mtDNA heteroplasmy in adult tissues is commonly seen in patients with a mixture of wild-type and mutant mtDNA. A mixture of different mtDNA variants may influence such variation and cause mtDNA segregation bias. We analyzed
Externí odkaz:
https://doaj.org/article/ac06f2f196f14f95a7a9f4b07d3df71a
Publikováno v:
Context, Principles and Practice of TransGynecology ISBN: 9781108899987
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::968743b8e562a1f69ff1afdeb2d86808
https://doi.org/10.1017/9781108899987.040
https://doi.org/10.1017/9781108899987.040
Autor:
Liesbeth Vossaert, Paulien Meert, Ellen Scheerlinck, Pieter Glibert, Nadine Van Roy, Björn Heindryckx, Petra De Sutter, Maarten Dhaenens, Dieter Deforce
Publikováno v:
Stem Cell Research, Vol 13, Iss 1, Pp 123-134 (2014)
Posttranslational histone modifications are essential features in epigenetic regulatory networks. One of these modifications has remained largely understudied: regulated histone proteolysis. In analogy to the histone H3 clipping during early mouse em
Externí odkaz:
https://doaj.org/article/a07065059c0749a6bcd070ef563aa442
Autor:
Wim Trypsteen, Filip Van Nieuwerburgh, Ward De Spiegelaere, Björn Heindryckx, Willem van Snippenberg, Mao-Xing Tang, Yannick Gansemans, Olivier Tytgat, Sofie Symoens, Ramesh Reddy Guggilla, Annekatrien Boel, Michiel Van Herp, Dieter Deforce, Paul Coucke
Publikováno v:
Clinical Chemistry. 67:968-976
Background The quantification of mitochondrial DNA heteroplasmy for the diagnosis of mitochondrial disease or after mitochondrial donation, is performed mainly using next-generation sequencing strategies (NGS). Digital PCR (dPCR) has the potential to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e712fc0adee6b0919baa49f4d08e97b
https://doi.org/10.1093/clinchem/hvab021
https://doi.org/10.1093/clinchem/hvab021